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Originally published In Press as doi:10.1074/jbc.C200398200 on July 11, 2002

J. Biol. Chem., Vol. 277, Issue 35, 31283-31286, August 30, 2002
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ACCELERATED PUBLICATION
INSL3/Leydig Insulin-like Peptide Activates the LGR8 Receptor Important in Testis Descent*

Jin KumagaiDagger , Sheau Yu HsuDagger , Hirotaka MatsumiDagger , Jae-Sook RohDagger , Ping Fu§, John D. Wade§, Ross A. D. Bathgate§, and Aaron J. W. HsuehDagger

From the Dagger  Division of Reproductive Biology, Department of Gynecology and Obstetrics, Stanford University School of Medicine, Stanford, California 94305-5317 and the § Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Victoria 3010, Australia

Several orphan G protein-coupled receptors homologous to gonadotropin and thyrotropin receptors have recently been identified and named as LGR4-8. INSL3, also known as Leydig insulin-like peptide or relaxin-like factor, is a relaxin family member expressed in testis Leydig cells and ovarian theca and luteal cells. Male mice mutant for INSL3 exhibit cryptorchidism or defects in testis descent due to abnormal gubernaculum development whereas overexpression of INSL3 induces ovary descent in transgenic females. Because transgenic mice missing the LGR8 gene are also cryptorchid, INSL3 was tested as the ligand for LGR8. Here, we show that treatment with INSL3 stimulated cAMP production in cells expressing recombinant LGR8 but not LGR7. In addition, interactions between INSL3 and LGR8 were demonstrated following ligand receptor cross-linking. Northern blot analysis indicated that the LGR8 transcripts are expressed in gubernaculum whereas treatment of cultured gubernacular cells with INSL3 stimulated cAMP production and thymidine incorporation. The present study identified the ligand for an orphan G protein-coupled receptor based on common phenotypes of ligand and receptor null mice. Demonstration of INSL3 as the ligand for LGR8 facilitates understanding of the mechanism of testis descent and allows studies on the role of INSL3 in gonadal and other physiological processes.

* This study was supported by National Institutes of Health Grant HD23273.The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

To whom correspondence should be addressed. Tel.: 650-725-6802; Fax: 650-725-7102; E-mail: aaron.hsueh@stanford.edu.

Copyright © 2002 by The American Society for Biochemistry and Molecular Biology, Inc.


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[Abstract] [Full Text] [PDF]

Home page
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Ann. N.Y. Acad. Sci., May 1, 2005; 1041(1): 1 - 7.
[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

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Home page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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Ann. N.Y. Acad. Sci., May 1, 2005; 1041(1): 205 - 210.
[Abstract] [Full Text] [PDF]

Home page
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Ann. N.Y. Acad. Sci., May 1, 2005; 1041(1): 211 - 215.
[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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Ann. N.Y. Acad. Sci., May 1, 2005; 1041(1): 292 - 295.
[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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Ann. N.Y. Acad. Sci., May 1, 2005; 1041(1): 497 - 505.
[Abstract] [Full Text] [PDF]

Home page
 Ann. N. Y. Acad. Sci.Home page
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Ann. N.Y. Acad. Sci., May 1, 2005; 1041(1): 510 - 515.
[Abstract] [Full Text] [PDF]

Home page
 Ann. N. Y. Acad. Sci.Home page
P. FU, P.-J. SHEN, C.-X. ZHAO, D. J. SCOTT, C. S. SAMUEL, J. D. WADE, G. W. TREGEAR, R. A.D. BATHGATE, and A. L. GUNDLACH
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Ann. N.Y. Acad. Sci., May 1, 2005; 1041(1): 516 - 519.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
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Multiple Binding Sites Revealed by Interaction of Relaxin Family Peptides with Native and Chimeric Relaxin Family Peptide Receptors 1 and 2 (LGR7 and LGR8)
J. Pharmacol. Exp. Ther., May 1, 2005; 313(2): 677 - 687.
[Abstract] [Full Text] [PDF]

Home page
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Ann. N.Y. Acad. Sci., May 1, 2005; 1041(1): xxix - xxix.
[Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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Home page
 J. Biol. Chem.Home page
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INSL5 Is a High Affinity Specific Agonist for GPCR142 (GPR100)
J. Biol. Chem., January 7, 2005; 280(1): 292 - 300.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
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J. Pharmacol. Exp. Ther., January 1, 2005; 312(1): 83 - 95.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
C. Liu, J. Chen, C. Kuei, S. Sutton, D. Nepomuceno, P. Bonaventure, and T. W. Lovenberg
Relaxin-3/Insulin-Like Peptide 5 Chimeric Peptide, a Selective Ligand for G Protein-Coupled Receptor (GPCR)135 and GPCR142 over Leucine-Rich Repeat-Containing G Protein-Coupled Receptor 7
Mol. Pharmacol., January 1, 2005; 67(1): 231 - 240.
[Abstract] [Full Text] [PDF]

Home page
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J. Clin. Endocrinol. Metab., December 1, 2004; 89(12): 5952 - 5958.
[Abstract] [Full Text] [PDF]

Home page
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Home page
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Home page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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K. Kawamura, J. Kumagai, S. Sudo, S.-Y. Chun, M. Pisarska, H. Morita, J. Toppari, P. Fu, J. D. Wade, R. A. D. Bathgate, et al.
Paracrine regulation of mammalian oocyte maturation and male germ cell survival
PNAS, May 11, 2004; 101(19): 7323 - 7328.
[Abstract] [Full Text] [PDF]