JBC Avanti Polar Lipids

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Originally published In Press as doi:10.1074/jbc.M204296200 on June 11, 2002

J. Biol. Chem., Vol. 277, Issue 35, 32360-32368, August 30, 2002
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
277/35/32360    most recent
M204296200v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Reunanen, N.
Right arrow Articles by Kähäri, V.-M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Reunanen, N.
Right arrow Articles by Kähäri, V.-M.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Activation of p38alpha MAPK Enhances Collagenase-1 (Matrix Metalloproteinase (MMP)-1) and Stromelysin-1 (MMP-3) Expression by mRNA Stabilization*

Niina ReunanenDagger §||, Song-Ping LiDagger §, Matti AhonenDagger §, Marco Foschi||, Jiahuai Han**, and Veli-Matti KähäriDagger §Dagger Dagger

From the Dagger  Centre for Biotechnology, University of Turku and Åbo Akademi University, and the § Departments of Medical Biochemistry and Dermatology, University of Turku, FIN-20520 Turku, Finland, the || Department of Internal Medicine, University of Florence, Florence 50134, Italy, and the ** Department of Immunology, Scripps Research Institute, La Jolla, California 92037

Here, we have examined the role of distinct MAPK pathways in the regulation of collagenase-1 (matrix metalloproteinase (MMP)-1) and stromelysin-1 (MMP-3) expression by human skin fibroblasts. Tumor necrosis factor-alpha rapidly and transiently activated ERK1/2 and JNK in fibroblasts, whereas the activation of p38 MAPK was more persistent. Inhibition of p38 activity by SB203580 markedly (by 80-90%) inhibited induction of MMP-1 and MMP-3 expression by tumor necrosis factor-alpha , whereas blocking the activation of ERK1/2 by PD98059 had no effect. Activation of endogenous ERK1/2 by adenovirus-mediated transfer of constitutively active MEK1 resulted in potent induction of MMP-1 and MMP-3 expression. Activation of endogenous or adenovirally expressed p38alpha by adenovirally delivered constitutively active MKK3b and MKK6b also enhanced MMP-1 and MMP-3 expression and augmented the up-regulatory effect of ERK1/2 activation on the expression of these MMPs. Activation of ERK1/2 resulted in induction of c-jun, junB, and c-fos expression, whereas activation of p38 alone had no effect. In contrast, activation of p38alpha resulted in marked stabilization of MMP-1 and MMP-3 mRNAs. These results identify two distinct and complementary signaling mechanisms mediating induction of MMP-1 and MMP-3 expression in dermal fibroblasts: AP-1-dependent transcriptional activation via the ERK1/2 pathway and AP-1-independent enhancement via p38alpha MAPK by mRNA stabilization. It is conceivable that both modes of action play an important role in controlling the proteolytic phenotype of fibroblasts, e.g. in wound repair and tumor invasion.

* This work was supported in part by Academy of Finland Project 45996, by grants from the Sigrid Jusélius Foundation and the Cancer Research Foundation of Finland, by Turku University Central Hospital Project 13336, by a research contract with the Finnish Life and Pension Insurance Companies, and by the Turku Graduate School of Biomedical Sciences.The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

Supported by grants from Finnish Culture Foundation of South-Western Finland, the Cancer Foundation of South-Western Finland, and the Finnish Medical Society Duodecim.

Dagger Dagger To whom correspondence should be addressed: Centre for Biotechnology, University of Turku, Tykistökatu 6B, FIN-20520 Turku, Finland. Tel.: 358-2-333-8029; Fax: 358-2-333-8000; E-mail: veli-matti.kahari@utu.fi.

Copyright © 2002 by The American Society for Biochemistry and Molecular Biology, Inc.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Ann Rheum DisHome page
G Schett, J Zwerina, and G Firestein
The p38 mitogen-activated protein kinase (MAPK) pathway in rheumatoid arthritis
Ann Rheum Dis, July 1, 2008; 67(7): 909 - 916.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
Z. Zhang, B. D. Humphreys, and J. V. Bonventre
Shedding of the Urinary Biomarker Kidney Injury Molecule-1 (KIM-1) Is Regulated by MAP Kinases and Juxtamembrane Region
J. Am. Soc. Nephrol., October 1, 2007; 18(10): 2704 - 2714.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
M. J. Kelley, A. Rose, K. Song, B. Lystrup, J. W. Samples, and T. S. Acott
p38 MAP Kinase Pathway and Stromelysin Regulation in Trabecular Meshwork Cells
Invest. Ophthalmol. Vis. Sci., July 1, 2007; 48(7): 3126 - 3137.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
N. Amara, R. Bachoual, M. Desmard, S. Golda, C. Guichard, S. Lanone, M. Aubier, E. Ogier-Denis, and J. Boczkowski
Diesel exhaust particles induce matrix metalloprotease-1 in human lung epithelial cells via a NADP(H) oxidase/NOX4 redox-dependent mechanism
Am J Physiol Lung Cell Mol Physiol, July 1, 2007; 293(1): L170 - L181.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. H. Pillinger, N. Marjanovic, S.-Y. Kim, Y.-C. Lee, J. U. Scher, J. Roper, A. M. Abeles, P. I. Izmirly, M. Axelrod, M. Y. Pillinger, et al.
Helicobacter pylori Stimulates Gastric Epithelial Cell MMP-1 Secretion via CagA-dependent and -independent ERK Activation
J. Biol. Chem., June 29, 2007; 282(26): 18722 - 18731.
[Abstract] [Full Text] [PDF]

Home page
 Ann Rheum DisHome page
M. Hoberg, M. Rudert, T. Pap, G. Klein, S. Gay, and W. K Aicher
Attachment to laminin-111 facilitates transforming growth factor {beta}-induced expression of matrix metalloproteinase-3 in synovial fibroblasts
Ann Rheum Dis, April 1, 2007; 66(4): 446 - 451.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
I. Palona, H. Namba, N. Mitsutake, D. Starenki, A. Podtcheko, I. Sedliarou, A. Ohtsuru, V. Saenko, Y. Nagayama, K. Umezawa, et al.
BRAFV600E Promotes Invasiveness of Thyroid Cancer Cells through Nuclear Factor {kappa}B Activation
Endocrinology, December 1, 2006; 147(12): 5699 - 5707.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
C. S. De Paiva, R. M. Corrales, A. L. Villarreal, W. Farley, D.-Q. Li, M. E. Stern, and S. C. Pflugfelder
Apical corneal barrier disruption in experimental murine dry eye is abrogated by methylprednisolone and doxycycline.
Invest. Ophthalmol. Vis. Sci., July 1, 2006; 47(7): 2847 - 2856.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Popov, E. Patsenker, M. Bauer, E. Niedobitek, A. Schulze-Krebs, and D. Schuppan
Halofuginone Induces Matrix Metalloproteinases in Rat Hepatic Stellate Cells via Activation of p38 and NF{kappa}B
J. Biol. Chem., June 2, 2006; 281(22): 15090 - 15098.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Ehling, A. Schaffler, H. Herfarth, I. H. Tarner, S. Anders, O. Distler, G. Paul, J. Distler, S. Gay, J. Scholmerich, et al.
The Potential of Adiponectin in Driving Arthritis
J. Immunol., April 1, 2006; 176(7): 4468 - 4478.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Krueger, T. Hundertmark, T. Kalinski, U. Peitz, T. Wex, P. Malfertheiner, M. Naumann, and A. Roessner
Helicobacter pylori Encoding the Pathogenicity Island Activates Matrix Metalloproteinase 1 in Gastric Epithelial Cells via JNK and ERK
J. Biol. Chem., February 3, 2006; 281(5): 2868 - 2875.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. Li, S. S.-m. Ng, J. Wang, L. Lai, S. Yi Leung, M. Franco, Y. Peng, M.-l. He, H.-f. Kung, and M. C.-m. Lin
EFA6A Enhances Glioma Cell Invasion through ADP Ribosylation Factor 6/Extracellular Signal-Regulated Kinase Signaling
Cancer Res., February 1, 2006; 66(3): 1583 - 1590.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
H. H. Kim, C. M. Shin, C.-H. Park, K. H. Kim, K. H. Cho, H. C. Eun, and J. H. Chung
Eicosapentaenoic acid inhibits UV-induced MMP-1 expression in human dermal fibroblasts
J. Lipid Res., August 1, 2005; 46(8): 1712 - 1720.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T. Inoue, D. Hammaker, D. L. Boyle, and G. S. Firestein
Regulation of p38 MAPK by MAPK Kinases 3 and 6 in Fibroblast-Like Synoviocytes
J. Immunol., April 1, 2005; 174(7): 4301 - 4306.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. H. Pillinger, N. Marjanovic, S.-Y. Kim, J. U. Scher, P. Izmirly, S. Tolani, V. Dinsell, Y.-C. Lee, M. J. Blaser, and S. B. Abramson
Matrix Metalloproteinase Secretion by Gastric Epithelial Cells Is Regulated by E Prostaglandins and MAPKs
J. Biol. Chem., March 18, 2005; 280(11): 9973 - 9979.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
V. Iyer, K. Pumiglia, and C. M. DiPersio
{alpha}3{beta}1 integrin regulates MMP-9 mRNA stability in immortalized keratinocytes: a novel mechanism of integrin-mediated MMP gene expression
J. Cell Sci., March 15, 2005; 118(6): 1185 - 1195.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
C. F. Deroanne, D. Hamelryckx, T. T. G. Ho, C. A. Lambert, P. Catroux, C. M. Lapiere, and B. V. Nusgens
Cdc42 downregulates MMP-1 expression by inhibiting the ERK1/2 pathway
J. Cell Sci., March 15, 2005; 118(6): 1173 - 1183.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. L. Gauthier, C. R. Pickering, C. J. Miller, C. A. Fordyce, K. L. Chew, H. K. Berman, and T. D. Tlsty
p38 Regulates Cyclooxygenase-2 in Human Mammary Epithelial Cells and Is Activated in Premalignant Tissue
Cancer Res., March 1, 2005; 65(5): 1792 - 1799.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
L. Luo, D.-Q. Li, A. Doshi, W. Farley, R. M. Corrales, and S. C. Pflugfelder
Experimental Dry Eye Stimulates Production of Inflammatory Cytokines and MMP-9 and Activates MAPK Signaling Pathways on the Ocular Surface
Invest. Ophthalmol. Vis. Sci., December 1, 2004; 45(12): 4293 - 4301.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
D.-Q. Li, Z. Chen, X. J. Song, L. Luo, and S. C. Pflugfelder
Stimulation of Matrix Metalloproteinases by Hyperosmolarity via a JNK Pathway in Human Corneal Epithelial Cells
Invest. Ophthalmol. Vis. Sci., December 1, 2004; 45(12): 4302 - 4311.
[Abstract] [Full Text] [PDF]

Home page
 Ann Rheum DisHome page
J Westra, P C Limburg, P de Boer, and M H van Rijswijk
Effects of RWJ 67657, a p38 mitogen activated protein kinase (MAPK) inhibitor, on the production of inflammatory mediators by rheumatoid synovial fibroblasts
Ann Rheum Dis, November 1, 2004; 63(11): 1453 - 1459.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. Van Themsche, T. Alain, A. E. Kossakowska, S. Urbanski, E. F. Potworowski, and Y. St-Pierre
Stromelysin-2 (Matrix Metalloproteinase 10) Is Inducible in Lymphoma Cells and Accelerates the Growth of Lymphoid Tumors In Vivo
J. Immunol., September 15, 2004; 173(6): 3605 - 3611.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
N. von Offenberg Sweeney, P. M Cummins, Y. A Birney, J. P Cullen, E. M Redmond, and P. A Cahill
Cyclic strain-mediated regulation of endothelial matrix metalloproteinase-2 expression and activity
Cardiovasc Res, September 1, 2004; 63(4): 625 - 634.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. T. Huntington, J. M. Shields, C. J. Der, C. A. Wyatt, U. Benbow, C. L. Slingluff Jr., and C. E. Brinckerhoff
Overexpression of Collagenase 1 (MMP-1) Is Mediated by the ERK Pathway in Invasive Melanoma Cells: ROLE OF BRAF MUTATION AND FIBROBLAST GROWTH FACTOR SIGNALING
J. Biol. Chem., August 6, 2004; 279(32): 33168 - 33176.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
P. Anderson, K. Phillips, G. Stoecklin, and N. Kedersha
Post-transcriptional regulation of proinflammatory proteins
J. Leukoc. Biol., July 1, 2004; 76(1): 42 - 47.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. R. Man, S. Rustaeus, D. M. Price, C. L. Chik, and A. K. Ho
Inhibition of p38 Mitogen-Activated Protein Kinase Enhances Adrenergic-Stimulated Arylalkylamine N-Acetyltransferase Activity in Rat Pinealocytes
Endocrinology, March 1, 2004; 145(3): 1167 - 1174.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
Z. Strakova, M. Szmidt, S. Srisuparp, and A. T. Fazleabas
Inhibition of Matrix Metalloproteinases Prevents the Synthesis of Insulin-Like Growth Factor Binding Protein-1 during Decidualization in the Baboon
Endocrinology, December 1, 2003; 144(12): 5339 - 5346.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
S.-G. Shian, Y.-R. Kao, F. Y.-H. Wu, and C.-W. Wu
Inhibition of Invasion and Angiogenesis by Zinc-Chelating Agent Disulfiram
Mol. Pharmacol., November 1, 2003; 64(5): 1076 - 1084.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
W.-C. Lai, M. Zhou, U. Shankavaram, G. Peng, and L. M. Wahl
Differential Regulation of Lipopolysaccharide-Induced Monocyte Matrix Metalloproteinase (MMP)-1 and MMP-9 by p38 and Extracellular Signal-Regulated Kinase 1/2 Mitogen-Activated Protein Kinases
J. Immunol., June 15, 2003; 170(12): 6244 - 6249.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S.-K. Leivonen, A. Chantry, L. Hakkinen, J. Han, and V.-M. Kahari
Smad3 Mediates Transforming Growth Factor-beta -induced Collagenase-3 (Matrix Metalloproteinase-13) Expression in Human Gingival Fibroblasts. EVIDENCE FOR CROSS-TALK BETWEEN Smad3 AND p38 SIGNALING PATHWAYS
J. Biol. Chem., November 22, 2002; 277(48): 46338 - 46346.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Molecular and Cellular Proteomics 
 Journal of Lipid Research   ASBMB Today 
Copyright © 2002 by the American Society for Biochemistry and Molecular Biology.