|
|
|
|||||||
|
|||||||||
J. Biol. Chem., Vol. 277, Issue 36, 33509-33517, September 6, 2002
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
From the Department of Pharmacology of Natural Products and
Clinical Pharmacology, University of Ulm, D-89081 Ulm, Germany
The mechanism of proinflammatory activation of
human monocytes by plasmin is unknown. Here we demonstrate that in
human primary monocytes, plasmin stimulates mitogen-activated protein
kinase (MAPK) signaling via phosphorylation of MAPK kinase 3/6 (MKK3/6) and p38 MAPK that triggers subsequent DNA binding of transcription factor activator protein-1 (AP-1). The AP-1 complex contained phosphorylated c-Jun and ATF2, and its DNA binding activity was blocked
by the p38 MAPK inhibitor SB203580. In addition, plasmin elicits Janus
kinase (JAK)/signal transducer and activator of transcription (STAT)
signaling, as detected by phosphorylation of JAK1 tyrosine kinase and
STAT1 and STAT3 proteins. Plasmin-induced DNA binding of STAT1 and
STAT3 was blocked by SB203580 and AG490, inhibitors of p38 MAPK and
JAK, respectively, but not by U0126, an inhibitor of MKK1/2. DNA
binding of NF-
The Serine Protease Plasmin Triggers Expression of MCP-1
and CD40 in Human Primary Monocytes via Activation of p38 MAPK and
Janus Kinase (JAK)/STAT Signaling Pathways*
B remained unaffected by any of these inhibitors. The
plasmin-induced signaling led to expression of monocyte chemoattractant
protein-1 (MCP-1) and CD40, which required activation of both p38 MAPK
and JAK/STAT signaling pathways. Additionally, signaling through
both p38 MAPK and JAK is involved in the plasmin-mediated
monocyte migration, whereas the
formylmethionylleucylphenylalanine-induced chemotaxis remained
unaffected. Taken together, our data demonstrate a novel function of
the serine protease plasmin in a proinflammatory signaling network.
*
This work was supported by the Deutsche
Forschungsgemeinschaft.The costs of publication of this
article were defrayed in part by the
payment of page charges. The article
must therefore be hereby marked
"advertisement" in
accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
To whom correspondence should be addressed: Dept. of Pharmacology
of Natural Products and Clinical Pharmacology, University of Ulm,
Helmholtzstr. 20, D-89081 Ulm, Germany. Tel.: 49-731-500-24280; Fax:
49-731-500-24299; E-mail: thomas.simmet@medizin.uni-ulm.de.
Copyright © 2002 by The American Society for Biochemistry and Molecular Biology, Inc.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  M. Wygrecka, L. M. Marsh, R. E. Morty, I. Henneke, A. Guenther, J. Lohmeyer, P. Markart, and K. T. Preissner Enolase-1 promotes plasminogen-mediated recruitment of monocytes to the acutely inflamed lung Blood, May 28, 2009; 113(22): 5588 - 5598. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Loeffler, Z. Haddad, M. Bonin, N. Romeike, M. Mezger, U. Schumacher, M. Kapp, F. Gebhardt, G.-U. Grigoleit, S. Stevanovic, et al. Interaction analyses of human monocytes co-cultured with different forms of Aspergillus fumigatus J. Med. Microbiol., January 1, 2009; 58(1): 49 - 58. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Tchaikovski, G. Fellbrich, and J. Waltenberger The Molecular Basis of VEGFR-1 Signal Transduction Pathways in Primary Human Monocytes Arterioscler. Thromb. Vasc. Biol., February 1, 2008; 28(2): 322 - 328. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Yang, M. Luo, R. Li, Y. Huang, R. Zhang, Q. Wu, F. Wang, Y. Li, and X. Yu Blockage of JAK/STAT signalling attenuates renal ischaemia-reperfusion injury in rats Nephrol. Dial. Transplant., January 1, 2008; 23(1): 91 - 100. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Buerke, D. Pruefer, D. Sankat, J. M. Carter, U. Buerke, M. Russ, A. Schlitt, I. Friedrich, J. Borgermann, C. F. Vahl, et al. Effects of Aprotinin on Gene Expression and Protein Synthesis After Ischemia and Reperfusion in Rats Circulation, September 11, 2007; 116(11_suppl): I-121 - I-126. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Zhang, Z.-H. Zhou, T. H. Bugge, and L. M. Wahl Urokinase-Type Plasminogen Activator Stimulation of Monocyte Matrix Metalloproteinase-1 Production Is Mediated by Plasmin-Dependent Signaling through Annexin A2 and Inhibited by Inactive Plasmin J. Immunol., September 1, 2007; 179(5): 3297 - 3304. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Li, Y. Laumonnier, T. Syrovets, and T. Simmet Plasmin Triggers Cytokine Induction in Human Monocyte-Derived Macrophages Arterioscler. Thromb. Vasc. Biol., June 1, 2007; 27(6): 1383 - 1389. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Zhang, K. A. Kernan, S. J. Collins, X. Cai, J. M. Lopez-Guisa, J. L. Degen, Y. Shvil, and A. A. Eddy Plasmin(ogen) Promotes Renal Interstitial Fibrosis by Promoting Epithelial-to-Mesenchymal Transition: Role of Plasmin-Activated Signals J. Am. Soc. Nephrol., March 1, 2007; 18(3): 846 - 859. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Renckens, J. M. Pater, and T. v. d. Poll Plasminogen Activator Inhibitor Type-1-Deficient Mice Have an Enhanced IFN-{gamma} Response to Lipopolysaccharide and Staphylococcal Enterotoxin B J. Immunol., December 1, 2006; 177(11): 8171 - 8176. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Bhattacharjee, B. Xu, D. A. Frank, G. M. Feldman, and M. K. Cathcart Monocyte 15-Lipoxygenase Expression Is Regulated by a Novel Cytosolic Signaling Complex with Protein Kinase C {delta} and Tyrosine-Phosphorylated Stat3 J. Immunol., September 15, 2006; 177(6): 3771 - 3781. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Martin-Ventura, V. Nicolas, X. Houard, L. M. Blanco-Colio, A. Leclercq, J. Egido, R. Vranckx, J.-B. Michel, and O. Meilhac Biological Significance of Decreased HSP27 in Human Atherosclerosis Arterioscler. Thromb. Vasc. Biol., June 1, 2006; 26(6): 1337 - 1343. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Laumonnier, T. Syrovets, L. Burysek, and T. Simmet Identification of the annexin A2 heterotetramer as a receptor for the plasmin-induced signaling in human peripheral monocytes Blood, April 15, 2006; 107(8): 3342 - 3349. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. R. Pendurthi, T. T. Tran, M. Post, and L. V. M. Rao Proteolysis of CCN1 by Plasmin: Functional Implications Cancer Res., November 1, 2005; 65(21): 9705 - 9711. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Syrovets, J. E. Gschwend, B. Buchele, Y. Laumonnier, W. Zugmaier, F. Genze, and T. Simmet Inhibition of I{kappa}B Kinase Activity by Acetyl-boswellic Acids Promotes Apoptosis in Androgen-independent PC-3 Prostate Cancer Cells in Vitro and in Vivo J. Biol. Chem., February 18, 2005; 280(7): 6170 - 6180. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Syrovets, B. Buchele, C. Krauss, Y. Laumonnier, and T. Simmet Acetyl-Boswellic Acids Inhibit Lipopolysaccharide-Mediated TNF-{alpha} Induction in Monocytes by Direct Interaction with I{kappa}B Kinases J. Immunol., January 1, 2005; 174(1): 498 - 506. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Oda, K. Yamakami, F. Omasu, S. Suzuki, S. Miura, T. Sugisaki, and N. Yoshizawa Glomerular Plasmin-Like Activity in Relation to Nephritis-Associated Plasmin Receptor in Acute Poststreptococcal Glomerulonephritis J. Am. Soc. Nephrol., January 1, 2005; 16(1): 247 - 254. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Wenk, J. Schuller, C. Hinrichs, T. Syrovets, N. Azoitei, M. Podda, M. Wlaschek, P. Brenneisen, L.-A. Schneider, A. Sabiwalsky, et al. Overexpression of Phospholipid-hydroperoxide Glutathione Peroxidase in Human Dermal Fibroblasts Abrogates UVA Irradiation-induced Expression of Interstitial Collagenase/Matrix Metalloproteinase-1 by Suppression of Phosphatidylcholine Hydroperoxide-mediated NF{kappa}B Activation and Interleukin-6 Release J. Biol. Chem., October 29, 2004; 279(44): 45634 - 45642. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Suzuki, H. Satonaka, H. Nishimatsu, S. Oba, R. Takeda, M. Omata, T. Fujita, R. Nagai, and Y. Hirata Myocyte Enhancer Factor 2 Mediates Vascular Inflammation via the p38-Dependent Pathway Circ. Res., July 9, 2004; 95(1): 42 - 49. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Marra, W. Delogu, I. Petrai, S. Pastacaldi, A. Bonacchi, E. Efsen, S. Aleffi, C. Bertolani, M. Pinzani, and P. Gentilini Differential requirement of members of the MAPK family for CCL2 expression by hepatic stellate cells Am J Physiol Gastrointest Liver Physiol, July 1, 2004; 287(1): G18 - G26. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Satonaka, E. Suzuki, H. Nishimatsu, S. Oba, R. Takeda, A. Goto, M. Omata, T. Fujita, R. Nagai, and Y. Hirata Calcineurin Promotes the Expression of Monocyte Chemoattractant Protein-1 in Vascular Myocytes and Mediates Vascular Inflammation Circ. Res., March 19, 2004; 94(5): 693 - 700. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Renckens, S. Weijer, A. F. de Vos, J. M. Pater, J. C. Meijers, C. E. Hack, M. Levi, and T. van der Poll Inhibition of Plasmin Activity by Tranexamic Acid Does Not Influence Inflammatory Pathways During Human Endotoxemia Arterioscler. Thromb. Vasc. Biol., March 1, 2004; 24(3): 483 - 488. [Abstract] [Full Text]
|
|
|
|
|
|
Q. Cao, K. M. Mak, C. Ren, and C. S. Lieber Leptin Stimulates Tissue Inhibitor of Metalloproteinase-1 in Human Hepatic Stellate Cells: RESPECTIVE ROLES OF THE JAK/STAT AND JAK-MEDIATED H2O2-DEPENDENT MAPK PATHWAYS J. Biol. Chem., February 6, 2004; 279(6): 4292 - 4304. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Colognato, J. R. Slupsky, M. Jendrach, L. Burysek, T. Syrovets, and T. Simmet Differential expression and regulation of protease-activated receptors in human peripheral monocytes and monocyte-derived antigen-presenting cells Blood, October 1, 2003; 102(7): 2645 - 2652. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Xu, A. Bhattacharjee, B. Roy, H.-M. Xu, D. Anthony, D. A. Frank, G. M. Feldman, and M. K. Cathcart Interleukin-13 Induction of 15-Lipoxygenase Gene Expression Requires p38 Mitogen-Activated Protein Kinase-Mediated Serine 727 Phosphorylation of Stat1 and Stat3 Mol. Cell. Biol., June 1, 2003; 23(11): 3918 - 3928. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |