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Originally published In Press as doi:10.1074/jbc.M200988200 on June 28, 2002

J. Biol. Chem., Vol. 277, Issue 37, 33683-33689, September 13, 2002
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The Role of ADAM 15 in Glomerular Mesangial Cell Migration*

John MartinDagger , Lisa V. Eynstone, Malcolm Davies, John D. Williams, and Robert Steadman

From the Institute of Nephrology, University of Wales College of Medicine, Heath Park, Cardiff, CF14 4XN, Wales, United Kingdom

Mesangial cells (MC) occupy the core of the renal glomerulus and are surrounded by a mesangial matrix. In certain diseases, MC migrate through this matrix into the pericapillary space. The mechanisms involved, however, are poorly understood. Members of the ADAM (A Disintegrin And Metalloproteinase) family of membrane proteins have the potential to be key modulators of cell-matrix interactions through the activities of their constituent domains. We have studied the possible role of ADAM 15 in human (H) MC migration in vitro. HMC ADAM 15 was expressed at low levels in serum-free medium but was increased during migration. Antibodies to the individual domains of ADAM 15 and the incorporation of antisense ADAM 15, (but not control oligonucleotide) inhibited this migration. Furthermore, inhibition of migration by the broad spectrum metalloproteinase inhibitor BB3103, demonstrated that metalloproteinase activity was essential for migration. ADAM 15, extracted from HMC membranes, was an active metalloproteinase, which degraded both type IV collagen and gelatin prepared from fibrillar collagen. Activity was inhibited by EDTA but not by phenylmethylsulfonyl fluoride. This is the first report of the potential of ADAM 15 for involvement in the restructuring of the mesangial matrix and in the migration of MC in disease.

* This work was supported by the National Kidney Research Fund and the Kidney Research Unit for Wales Foundation.The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

Dagger To whom correspondence should be addressed. Tel.: 44-029-2074-8446; Fax: 44-029-2074-8470; Email: martinj1@cf.ac.uk.

Copyright © 2002 by The American Society for Biochemistry and Molecular Biology, Inc.
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