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J. Biol. Chem., Vol. 277, Issue 37, 34413-34423, September 13, 2002
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From the OS-9, a protein previously uncharacterized, was
shown to interact specifically with the intracellular region of the
membrane proteinase meprin This paper is dedicated to the memory of our mentor, distinguished
scientist and friend, Shmuel Shaltiel.
A Selective Interaction between OS-9 and the Carboxyl-terminal
Tail of Meprin
*
§,
¶
Department of Adult Oncology, Dana-Farber
Cancer Institute, Boston, Massachusetts 02115 and the
¶ Department of Biological Regulation, The Weizmann Institute of
Science, Rehovot 76100, Israel
found in brush border membranes of
kidney and small intestine. We have shown previously that this
cytoplasmic region is indispensable for the maturation of meprin ,
which included an endoplasmic reticulum (ER)-to-Golgi translocation. We
characterized OS-9 and found that it is associated with ER membranes
and that it is exposed to the cytoplasm. Consistent with the kinetics
of maturation of meprin , OS-9 associates with meprin only
transiently, coinciding with ER-to-Golgi transport of meprin . The
OS-9-binding site in the cytoplasmic domain of meprin overlaps the
region essential for this transport. We characterized alternatively
spliced forms of rat and mouse OS-9, and we found that only the
non-spliced form of OS-9 binds to meprin , implicating the spliced
out segment in the binding, and suggesting the possible mechanism of
the regulation of OS-9 function. Taken together, our results indicated
that OS-9 may be involved in the ER-to-Golgi transport of meprin .
Ubiquitous expression of OS-9 raises the possibility that it may
interact with other membrane proteins that possess the cytoplasmic
moiety homologous to that of meprin during their ER-to-Golgi transition.
*
This work was supported in part by The Israel Science
Foundation.The costs of publication of this
article were defrayed in part by the
payment of page charges. The article
must therefore be hereby marked
"advertisement" in
accordance with 18 U.S.C. Section
1734 solely to indicate this fact.
Deceased.
§
To whom correspondence should be addressed: Dept. of Adult
Oncology, Dana-Farber Cancer Institute, 44 Binney St., Mayer Bldg. 444, Boston, MA 02115. Tel.: 617-632-2209; Fax: 617-632-4760; E-mail:
larisa_litovchick@dfci.harvard.edu.
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