HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

J. Biol. Chem., Vol. 277, Issue 38, 34658-34661, September 20, 2002

This Article Full Text Full Text (PDF) All Versions of this Article: 277/38/34658    most recent C200362200v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Ma, K. Articles by Chan, L. Search for Related Content PubMed PubMed Citation Articles by Ma, K. Articles by Chan, L. Social Bookmarking                      What's this?

ACCELERATED PUBLICATION
Increased -Oxidation but No Insulin Resistance or Glucose Intolerance in Mice Lacking Adiponectin^*

Ke Ma, Agatha Cabrero, Pradip K. Saha, Hideto Kojima, Lan Li, Benny Hung-Junn Chang, Antoni Paul, and Lawrence Chan

From the Section of Endocrinology & Metabolism, Departments of Medicine and Molecular & Cellular Biology, Baylor College of Medicine and the St. Luke's Episcopal Hospital, Texas Medical Center, Houston, Texas 77030

Previous reports showed that recombinant fragments of adiponectin (adipo) displayed pharmacological effects when injected into rodents, but the relevance of these observations to the physiological function of adipo is unclear. We generated Adipo^/ mice by gene targeting. Adipo^/ mice are fertile with normal body and fat pad weights. Plasma glucose and insulin levels of Adipo^/ and Adipo^+/+ mice are similar under fasting conditions and during an intraperitoneal glucose tolerance test (GTT). Insulin tolerance test (ITT) also produces similar plasma glucose and insulin levels in the two groups of mice. Hyperinsulinemic-euglycemic clamp analysis showed that Adipo^/ and Adipo^+/+ mice have similar glucose infusion rates to maintain a similar serum glucose. High-fat diet feeding for 7 months led to similar weight gain and similar GTT and ITT responses. We next measured -oxidation and found it to be significantly increased in muscle and liver of Adipo^/ mice. In conclusion, our study indicates that absence of adipo causes increased -oxidation but does not cause glucose intolerance or insulin resistance in mice.

CiteULike

Complore

Connotea

Del.icio.us

Digg

Reddit

Technorati

This article has been cited by other articles:

				H. Teoh, A. Quan, K. W. A. Bang, G. Wang, F. Lovren, V. Vu, J. J. Haitsma, P. E. Szmitko, M. Al-Omran, C.-H. Wang, et al. Adiponectin deficiency promotes endothelial activation and profoundly exacerbates sepsis-related mortality Am J Physiol Endocrinol Metab, September 1, 2008; 295(3): E658 - E664. [Abstract] [Full Text] [PDF]

				M. Pini, M. E. Gove, J. A. Sennello, J. W. P. M. van Baal, L. Chan, and G. Fantuzzi Role and Regulation of Adipokines during Zymosan-Induced Peritoneal Inflammation in Mice Endocrinology, August 1, 2008; 149(8): 4080 - 4085. [Abstract] [Full Text] [PDF]

				M. P. Krause, Y. Liu, V. Vu, L. Chan, A. Xu, M. C. Riddell, G. Sweeney, and T. J. Hawke Adiponectin is expressed by skeletal muscle fibers and influences muscle phenotype and function Am J Physiol Cell Physiol, July 1, 2008; 295(1): C203 - C212. [Abstract] [Full Text] [PDF]

				R. L.C. Hoo, W.S. Chow, M.H. Yau, A. Xu, A. W.K. Tso, H.F. Tse, C. H.Y. Fong, S. Tam, L. Chan, and K. S.L. Lam Adiponectin Mediates the Suppressive Effect of Rosiglitazone on Plasminogen Activator Inhibitor-1 Production Arterioscler. Thromb. Vasc. Biol., December 1, 2007; 27(12): 2777 - 2782. [Abstract] [Full Text] [PDF]

				S. Otabe, X. Yuan, T. Fukutani, N. Wada, T. Hashinaga, H. Nakayama, N. Hirota, M. Kojima, and K. Yamada Overexpression of human adiponectin in transgenic mice results in suppression of fat accumulation and prevention of premature death by high-calorie diet Am J Physiol Endocrinol Metab, July 1, 2007; 293(1): E210 - E218. [Abstract] [Full Text] [PDF]

				G. Fantuzzi and T. Mazzone Adipose Tissue and Atherosclerosis: Exploring the Connection Arterioscler. Thromb. Vasc. Biol., May 1, 2007; 27(5): 996 - 1003. [Abstract] [Full Text] [PDF]

				T. A. Hopkins, N. Ouchi, R. Shibata, and K. Walsh Adiponectin actions in the cardiovascular system Cardiovasc Res, April 1, 2007; 74(1): 11 - 18. [Abstract] [Full Text] [PDF]

				L. Tao, E. Gao, X. Jiao, Y. Yuan, S. Li, T. A. Christopher, B. L. Lopez, W. Koch, L. Chan, B. J. Goldstein, et al. Adiponectin Cardioprotection After Myocardial Ischemia/Reperfusion Involves the Reduction of Oxidative/Nitrative Stress Circulation, March 20, 2007; 115(11): 1408 - 1416. [Abstract] [Full Text] [PDF]

				H. Wu, S. Ghosh, X. D. Perrard, L. Feng, G. E. Garcia, J. L. Perrard, J. F. Sweeney, L. E. Peterson, L. Chan, C. W. Smith, et al. T-Cell Accumulation and Regulated on Activation, Normal T Cell Expressed and Secreted Upregulation in Adipose Tissue in Obesity Circulation, February 27, 2007; 115(8): 1029 - 1038. [Abstract] [Full Text] [PDF]

				M. Pini, J. A. Sennello, L. Chan, and G. Fantuzzi Adiponectin Deficiency Does Not Affect the Inflammatory Response to Endotoxin or Concanavalin A in Mice Endocrinology, November 1, 2006; 147(11): 5019 - 5022. [Abstract] [Full Text] [PDF]

				S. Ledoux, D. B. Campos, F. L. Lopes, M. Dobias-Goff, M.-F. Palin, and B. D. Murphy Adiponectin Induces Periovulatory Changes in Ovarian Follicular Cells Endocrinology, November 1, 2006; 147(11): 5178 - 5186. [Abstract] [Full Text] [PDF]

				R. S. Streeper, S. K. Koliwad, C. J. Villanueva, and R. V. Farese Jr. Effects of DGAT1 deficiency on energy and glucose metabolism are independent of adiponectin Am J Physiol Endocrinol Metab, August 1, 2006; 291(2): E388 - E394. [Abstract] [Full Text] [PDF]

				Y. Takemura, Y. Osuga, T. Yamauchi, M. Kobayashi, M. Harada, T. Hirata, C. Morimoto, Y. Hirota, O. Yoshino, K. Koga, et al. Expression of Adiponectin Receptors and Its Possible Implication in the Human Endometrium Endocrinology, July 1, 2006; 147(7): 3203 - 3210. [Abstract] [Full Text] [PDF]

				Y. Wang, K. S. L. Lam, L. Chan, K. W. Chan, J. B. B. Lam, M. C. Lam, R. C. L. Hoo, W. W. N. Mak, G. J. S. Cooper, and A. Xu Post-translational Modifications of the Four Conserved Lysine Residues within the Collagenous Domain of Adiponectin Are Required for the Formation of Its High Molecular Weight Oligomeric Complex J. Biol. Chem., June 16, 2006; 281(24): 16391 - 16400. [Abstract] [Full Text] [PDF]

				A. R. Nawrocki, M. W. Rajala, E. Tomas, U. B. Pajvani, A. K. Saha, M. E. Trumbauer, Z. Pang, A. S. Chen, N. B. Ruderman, H. Chen, et al. Mice Lacking Adiponectin Show Decreased Hepatic Insulin Sensitivity and Reduced Responsiveness to Peroxisome Proliferator-activated Receptor {gamma} Agonists J. Biol. Chem., February 3, 2006; 281(5): 2654 - 2660. [Abstract] [Full Text] [PDF]

				M Mitchell, D T Armstrong, R L Robker, and R J Norman Adipokines: implications for female fertility and obesity Reproduction, November 1, 2005; 130(5): 583 - 597. [Abstract] [Full Text] [PDF]

				Y. Fu, N. Luo, R. L. Klein, and W. T. Garvey Adiponectin promotes adipocyte differentiation, insulin sensitivity, and lipid accumulation J. Lipid Res., July 1, 2005; 46(7): 1369 - 1379. [Abstract] [Full Text] [PDF]

				U. Salmenniemi, J. Zacharova, E. Ruotsalainen, I. Vauhkonen, J. Pihlajamaki, S. Kainulainen, K. Punnonen, and M. Laakso Association of Adiponectin Level and Variants in the Adiponectin Gene with Glucose Metabolism, Energy Expenditure, and Cytokines in Offspring of Type 2 Diabetic Patients J. Clin. Endocrinol. Metab., July 1, 2005; 90(7): 4216 - 4223. [Abstract] [Full Text] [PDF]

				T. Kadowaki and T. Yamauchi Adiponectin and Adiponectin Receptors Endocr. Rev., May 1, 2005; 26(3): 439 - 451. [Abstract] [Full Text] [PDF]

				H. Satoh, M.T. A. Nguyen, M. Trujillo, T. Imamura, I. Usui, P. E. Scherer, and J. M. Olefsky Adenovirus-Mediated Adiponectin Expression Augments Skeletal Muscle Insulin Sensitivity in Male Wistar Rats Diabetes, May 1, 2005; 54(5): 1304 - 1313. [Abstract] [Full Text] [PDF]

				E. Lord, S. Ledoux, B. D. Murphy, D. Beaudry, and M. F. Palin Expression of adiponectin and its receptors in swine J Anim Sci, March 1, 2005; 83(3): 565 - 578. [Abstract] [Full Text] [PDF]

				F. Gibson and P. Froguel Genetics of the APM1 Locus and Its Contribution to Type 2 Diabetes Susceptibility in French Caucasians Diabetes, November 1, 2004; 53(11): 2977 - 2983. [Abstract] [Full Text] [PDF]

				C Bolduc, M Larose, M Yoshioka, P Ye, P Belleau, C Labrie, J Morissette, V Raymond, F Labrie, and J St-Amand Effects of dihydrotestosterone on adipose tissue measured by serial analysis of gene expression J. Mol. Endocrinol., October 1, 2004; 33(2): 429 - 444. [Abstract] [Full Text] [PDF]

				P. K. Saha, H. Kojima, J. Martinez-Botas, A. L. Sunehag, and L. Chan Metabolic Adaptations in the Absence of Perilipin: INCREASED {beta}-OXIDATION AND DECREASED HEPATIC GLUCOSE PRODUCTION ASSOCIATED WITH PERIPHERAL INSULIN RESISTANCE BUT NORMAL GLUCOSE TOLERANCE IN PERILIPIN-NULL MICE J. Biol. Chem., August 20, 2004; 279(34): 35150 - 35158. [Abstract] [Full Text] [PDF]

				G. W. Wong, J. Wang, C. Hug, T.-S. Tsao, and H. F. Lodish A family of Acrp30/adiponectin structural and functional paralogs PNAS, July 13, 2004; 101(28): 10302 - 10307. [Abstract] [Full Text] [PDF]

				U. J. F. Tietge, K. H. W. Boker, M. P. Manns, and M. J. Bahr Elevated circulating adiponectin levels in liver cirrhosis are associated with reduced liver function and altered hepatic hemodynamics Am J Physiol Endocrinol Metab, July 1, 2004; 287(1): E82 - E89. [Abstract] [Full Text] [PDF]

				A. Xu, S. Yin, L. Wong, K. Weng Chan, and K. S. L. Lam Adiponectin Ameliorates Dyslipidemia Induced by the Human Immunodeficiency Virus Protease Inhibitor Ritonavir in Mice Endocrinology, February 1, 2004; 145(2): 487 - 494. [Abstract] [Full Text] [PDF]

				P. J. Havel Update on Adipocyte Hormones: Regulation of Energy Balance and Carbohydrate/Lipid Metabolism Diabetes, February 1, 2004; 53(90001): S143 - 151. [Abstract] [Full Text]

				H. Chen, M. Montagnani, T. Funahashi, I. Shimomura, and M. J. Quon Adiponectin Stimulates Production of Nitric Oxide in Vascular Endothelial Cells J. Biol. Chem., November 7, 2003; 278(45): 45021 - 45026. [Abstract] [Full Text] [PDF]

				T. Masaki, S. Chiba, T. Yasuda, T. Tsubone, T. Kakuma, I. Shimomura, T. Funahashi, Y. Matsuzawa, and H. Yoshimatsu Peripheral, But Not Central, Administration of Adiponectin Reduces Visceral Adiposity and Upregulates the Expression of Uncoupling Protein in Agouti Yellow (Ay/a) Obese Mice Diabetes, September 1, 2003; 52(9): 2266 - 2273. [Abstract] [Full Text] [PDF]

				J. M. Bruun, A. S. Lihn, C. Verdich, S. B. Pedersen, S. Toubro, A. Astrup, and B. Richelsen Regulation of adiponectin by adipose tissue-derived cytokines: in vivo and in vitro investigations in humans Am J Physiol Endocrinol Metab, September 1, 2003; 285(3): E527 - E533. [Abstract] [Full Text] [PDF]

				F. Orio Jr., S. Palomba, T. Cascella, G. Milan, R. Mioni, C. Pagano, F. Zullo, A. Colao, G. Lombardi, and R. Vettor Adiponectin Levels in Women with Polycystic Ovary Syndrome J. Clin. Endocrinol. Metab., June 1, 2003; 88(6): 2619 - 2623. [Abstract] [Full Text] [PDF]

				R. Weiss, S. Dufour, A. Groszmann, K. Petersen, J. Dziura, S. E. Taksali, G. Shulman, and S. Caprio Low Adiponectin Levels in Adolescent Obesity: A Marker of Increased Intramyocellular Lipid Accumulation J. Clin. Endocrinol. Metab., May 1, 2003; 88(5): 2014 - 2018. [Abstract] [Full Text] [PDF]

				Q. Tong, J.-L. Sankale, C. M. Hadigan, G. Tan, E. S. Rosenberg, P. J. Kanki, S. K. Grinspoon, and G. S. Hotamisligil Regulation of Adiponectin in Human Immunodeficiency Virus-Infected Patients: Relationship to Body Composition and Metabolic Indices J. Clin. Endocrinol. Metab., April 1, 2003; 88(4): 1559 - 1564. [Abstract] [Full Text] [PDF]