HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

J. Biol. Chem., Vol. 277, Issue 39, 35787-35790, September 27, 2002

This Article Full Text Full Text (PDF) All Versions of this Article: 277/39/35787    most recent C200346200v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Zhu, W. Articles by David, M. Search for Related Content PubMed PubMed Citation Articles by Zhu, W. Articles by David, M.

ACCELERATED PUBLICATION
Arginine Methylation of STAT1 Regulates Its Dephosphorylation by T Cell Protein Tyrosine Phosphatase^*

Wei Zhu, Tomas Mustelin^§, and Michael David^¶

From the  Division of Biology and University of California San Diego Cancer Center, University of California at San Diego, La Jolla, California 92093 and ^§ The Burnham Institute, La Jolla, California 92037

Transcriptional induction by interferons requires the tyrosine and serine phosphorylation of the STAT1 transcription factor as well as its amino-terminal arginine methylation. Here we show that arginine methylation of STAT1 controls the rate of STAT1 dephosphorylation by modulating its interaction with PIAS1 and the nuclear tyrosine phosphatase TcPTP. Inhibition of STAT1 arginine methylation, or mutation of STAT1 Arg-31, results in a prolonged half-life of STAT1 tyrosine phosphorylation. This effect appears to be mediated by an increased binding of PIAS1 to STAT1 in the absence of STAT1 arginine methylation and a concomitant decrease in the association of STAT1 with TcPTP. Furthermore, inhibitors of arginine methylation require the presence of PIAS1 to exert their negative regulatory effect on the dephosphorylation of STAT1.

This article has been cited by other articles:

				C. Leon, D. Nandan, M. Lopez, A. Moeenrezakhanlou, and N. E. Reiner Annexin V Associates with the IFN-{gamma} Receptor and Regulates IFN-{gamma} Signaling J. Immunol., May 15, 2006; 176(10): 5934 - 5942. [Abstract] [Full Text] [PDF]

				W. Komyod, U.-M. Bauer, P. C. Heinrich, S. Haan, and I. Behrmann Are STATS Arginine-methylated? J. Biol. Chem., June 10, 2005; 280(23): 21700 - 21705. [Abstract] [Full Text] [PDF]

				F.-M. Boisvert, C. A. Chenard, and S. Richard Protein Interfaces in Signaling Regulated by Arginine Methylation Sci. Signal., February 15, 2005; 2005(271): re2 - re2. [Abstract] [Full Text] [PDF]

				W. Chen, M. O. Daines, and G. K. K. Hershey Methylation of STAT6 Modulates STAT6 Phosphorylation, Nuclear Translocation, and DNA-Binding Activity J. Immunol., June 1, 2004; 172(11): 6744 - 6750. [Abstract] [Full Text] [PDF]

				W. A. Smith, B. T. Schurter, F. Wong-Staal, and M. David Arginine Methylation of RNA Helicase A Determines Its Subcellular Localization J. Biol. Chem., May 28, 2004; 279(22): 22795 - 22798. [Abstract] [Full Text] [PDF]

				T. B. Miranda, M. Miranda, A. Frankel, and S. Clarke PRMT7 Is a Member of the Protein Arginine Methyltransferase Family with a Distinct Substrate Specificity J. Biol. Chem., May 28, 2004; 279(22): 22902 - 22907. [Abstract] [Full Text] [PDF]

				S. Sakamoto, J. Qin, A. Navarro, A. Gamero, R. Potla, T. Yi, W. Zhu, D. P. Baker, G. Feldman, and A. C. Larner Cells Previously Desensitized to Type 1 Interferons Display Different Mechanisms of Activation of Stat-dependent Gene Expression from Naive Cells J. Biol. Chem., January 30, 2004; 279(5): 3245 - 3253. [Abstract] [Full Text] [PDF]

				C.-C. Lin, C.-M. Chou, Y.-L. Hsu, J.-C. Lien, Y.-M. Wang, S.-T. Chen, S.-C. Tsai, P.-W. Hsiao, and C.-J. Huang Characterization of Two Mosquito STATs, AaSTAT and CtSTAT: DIFFERENTIAL REGULATION OF TYROSINE PHOSPHORYLATION AND DNA BINDING ACTIVITY BY LIPOPOLYSACCHARIDE TREATMENT AND BY JAPANESE ENCEPHALITIS VIRUS INFECTION J. Biol. Chem., January 30, 2004; 279(5): 3308 - 3317. [Abstract] [Full Text] [PDF]

				Y. Hoshiya, V. Gupta, H. Kawakubo, E. Brachtel, J. L. Carey, L. Sasur, A. Scott, P. K. Donahoe, and S. Maheswaran Mullerian Inhibiting Substance Promotes Interferon {gamma}-induced Gene Expression and Apoptosis in Breast Cancer Cells J. Biol. Chem., December 19, 2003; 278(51): 51703 - 51712. [Abstract] [Full Text] [PDF]

				T. Meyer, A. Marg, P. Lemke, B. Wiesner, and U. Vinkemeier DNA binding controls inactivation and nuclear accumulation of the transcription factor Stat1 Genes & Dev., August 15, 2003; 17(16): 1992 - 2005. [Abstract] [Full Text] [PDF]

				K. M. McBride and N. C. Reich The Ins and Outs of STAT1 Nuclear Transport Sci. Signal., August 12, 2003; 2003(195): re13 - re13. [Abstract] [Full Text] [PDF]

				K. De Bosscher, W. Vanden Berghe, and G. Haegeman The Interplay between the Glucocorticoid Receptor and Nuclear Factor-{kappa}B or Activator Protein-1: Molecular Mechanisms for Gene Repression Endocr. Rev., August 1, 2003; 24(4): 488 - 522. [Abstract] [Full Text] [PDF]

				M. Dupuis, M. de Jesus Ibarra-Sanchez, M. L. Tremblay, and P. Duplay Gr-1+ Myeloid Cells Lacking T Cell Protein Tyrosine Phosphatase Inhibit Lymphocyte Proliferation by an IFN-{gamma}- and Nitric Oxide-Dependent Mechanism J. Immunol., July 15, 2003; 171(2): 726 - 732. [Abstract] [Full Text] [PDF]

				M. PELLETIER and L. K. READ RBP16 is a multifunctional gene regulatory protein involved in editing and stabilization of specific mitochondrial mRNAs in Trypanosoma brucei RNA, April 1, 2003; 9(4): 457 - 468. [Abstract] [Full Text] [PDF]

				S. Galic, M. Klingler-Hoffmann, M. T. Fodero-Tavoletti, M. A. Puryer, T.-C. Meng, N. K. Tonks, and T. Tiganis Regulation of Insulin Receptor Signaling by the Protein Tyrosine Phosphatase TCPTP Mol. Cell. Biol., March 15, 2003; 23(6): 2096 - 2108. [Abstract] [Full Text] [PDF]