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J. Biol. Chem., Vol. 277, Issue 39, 36009-36017, September 27, 2002
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From the Unit on Temporal Gene Expression, Laboratory of Cellular
and Molecular Regulation, National Institute of Mental Health,
Bethesda, Maryland 20892
The E-Box is a widely used DNA control element.
Despite its brevity and broad distribution the E-Box is a remarkably
versatile sequence that affects many different genetic programs,
including proliferation, differentiation, tissue-specific responses,
and cell death. The circadian clock is one of the latest pathways shown
to employ this element. In this context, E-Boxes are likely to
play a key role in establishing the robust waves of gene expression characteristic of circadian transcription. The regulatory flexibility of the E-Box hinges on the sequence ambiguity allowed at its core, the
strong influence of the surrounding sequences, and the recruitment of
spatially and temporally regulated E-Box-binding factors. Therefore, understanding how a particular E-Box can accomplish a specific task
entails the identification and systematic analysis of these cis- and
trans-acting E-Box modifiers. In the present study we compared the
E-Box-containing minimal promoters of vasopressin and
cyclin B1, two genes that can respond to the
transcriptional oscillators driving the circadian clock and cell cycle,
respectively. Results of this comparison will help elucidate the manner
in which discreet DNA modules associate to either augment or restrain
the activation of potential circadian E-Boxes in response to competing regulatory signals.
To whom correspondence should be addressed: Bldg. 36, Rm. 2A-09,
National Institutes of Health, Bethesda, MD 20892. Tel.: 301-435-7522;
Fax: 301-402-1748; E-mail: abri@codon.nih.gov.
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