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J. Biol. Chem., Vol. 277, Issue 4, 2517-2524, January 25, 2002
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From the The CBP and p300 co-activators play a key role in
many aspects of gene regulation being recruited to the DNA via
transcription factors that are targets for specific signaling pathways.
It has previously been demonstrated that in neuronal cells the ability of CBP and p300 to activate transcription can be directly stimulated by
nerve growth factor or calcium-activated signaling pathways. Here we demonstrate that, in cardiac cells, the activity of CBP and
p300 is stimulated by phenylephrine (PE) treatment and that they are
required for the activation of atrial naturetic factor (ANF) gene
expression by PE. Activation of CBP/p300 by PE involves the p42/p44
MAPK pathway and targets primarily the N terminus of p300 and the C
terminus of CBP, which are not homologous to one another. To our
knowledge, this is the first report of a specific stimulus modulating
the activity of CBP and p300 in cardiac cells and it suggests that
these factors play an important role in the hypertrophic effect of
PE.
The Transcriptional Co-activators CBP and p300 Are Activated via
Phenylephrine through the p42/p44 MAPK Cascade*
§,,,
, and**
Institute of Child Health, University
College London, 30 Guilford St., London WC1N 1EH, United Kingdom, the
¶ Jefferson Cancer Institute, Thomas Jefferson University,
Philadelphia, Pennsylvania 19107, and the Department of
Pharmacology and Physiological Sciences, St. Louis University School of
Medicine, St. Louis, Missouri 63104
*
This work was supported in part by the British Heart
Foundation.The costs of publication of this
article were defrayed in part by the
payment of page charges. The article
must therefore be hereby marked
"advertisement" in
accordance with 18 U.S.C. Section
1734 solely to indicate this fact.
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