JBC

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Originally published In Press as doi:10.1074/jbc.M109652200 on November 15, 2001

J. Biol. Chem., Vol. 277, Issue 4, 2869-2875, January 25, 2002
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
277/4/2869    most recent
M109652200v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Jaulin-Bastard, F.
Right arrow Articles by Borg, J.-P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jaulin-Bastard, F.
Right arrow Articles by Borg, J.-P.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Interaction between Erbin and a Catenin-related Protein in Epithelial Cells*

Fanny Jaulin-Bastardab, Jean-Pierre Arsantoc, André Le Bivicc, Christel Navarroade, Frédéric Vélyf, Hiroko Saitoag, Sylvie Marchettoa, Mechthild Hatzfeldhi, Marie-Josée Santonia, Daniel Birnbauma, and Jean-Paul Borgadj

From the a U119 INSERM, Molecular Oncology, d Institut Paoli-Calmettes, Molecular Pharmacology, 27 boulevard Leï Roure 13009 Marseille, France, c IBDM, LGPD Faculté des Sciences de Luminy, case 907, 13288 Marseille cedex 09, France, f Centre d'Immunologie de Marseille-Luminy, CNRS-INSERM-Université de la Méditerranée, Parc Scientifique de Luminy, case 906, 13288 Marseille cedex 09, France, and the h Molecular Biology Group, University of Halle, Magdeburger Strasse 18, 06097 Halle, Germany

Integrity of epithelial tissues relies on the proper apical-basolateral polarity of epithelial cells. Members of the LAP (LRR and PDZ) protein family such as LET-413 and Scribble are involved in maintaining epithelial cell polarity in Caenorhabditis elegans and Drosophila melanogaster, respectively. We previously described Erbin as a mammalian LET-413 homologue interacting with ERBB2/HER2, an epidermal growth factor receptor family member. Erbin and ERBB2/HER2 are located in the basolateral membranes of epithelial cells. We show here that Erbin interacts with p0071 (also called plakophilin-4), an armadillo repeat protein linked to the cytoskeleton. Erbin binds to p0071 in vitro and in vivo in a PDZ domain-dependent manner, and both proteins colocalized in desmosomes of epithelial cells. Using a dominant negative approach, we found that integrity of epithelial cell monolayer is impaired when interaction between Erbin and p0071 is disrupted. We propose that Erbin is connected by p0071 to cytoskeletal networks in an interaction crucial for epithelial homeostasis.

* This project is supported by INSERM, ARC, La Ligue Nationale Contre le Cancer (Label Ligue), Fondation de France (to J.-P. B.) and Institute Paoli-Calmettes (to D. B. and J.-P. B.).The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

b Recipient of a Ministry of Research and Technology fellowship.

e Recipient of a Conseil Régional fellowship.

g Recipient of a Japanese-French fellowship.

i Supported by Deutsche Forschungsgemeinschaft grants Ha1791/3-3 and Ha1791/5-2 and the BMBF (Molecular Biology Group of Medical Faculty).

j To whom correspondence should be addressed: U119 INSERM, Molecular Oncology, 27 Blvd. Leï Roure 13009 Marseille, France. Tel.: 33-4-91-75-84-09; Fax: 33-4-91-26-03-64; E-mail: borg@marseille.inserm.fr.

Copyright © 2002 by The American Society for Biochemistry and Molecular Biology, Inc.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 GENES CELLSHome page
I. Izawa, M. Nishizawa, Y. Hayashi, and M. Inagaki
Palmitoylation of ERBIN is required for its plasma membrane localization.
Genes Cells, July 1, 2008; 13(7): 691 - 701.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
D. D. Mruk, B. Silvestrini, and C. Y. Cheng
Anchoring Junctions As Drug Targets: Role in Contraceptive Development
Pharmacol. Rev., June 1, 2008; 60(2): 146 - 180.
[Abstract] [Full Text] [PDF]

Home page
 J BiochemHome page
N. Liu, J. Zhang, J. Zhang, S. Liu, Y. Liu, and D. Zheng
Erbin-regulated Sensitivity of MCF-7 Breast Cancer Cells to TRAIL via ErbB2/AKT/NF-{kappa}B Pathway
J. Biochem., June 1, 2008; 143(6): 793 - 801.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
F. Dai, C. Chang, X. Lin, P. Dai, L. Mei, and X.-H. Feng
Erbin Inhibits Transforming Growth Factor {beta} Signaling through a Novel Smad-Interacting Domain
Mol. Cell. Biol., September 1, 2007; 27(17): 6183 - 6194.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. B. Silverman, S. Restituito, W. Lu, L. Lee-Edwards, L. Khatri, and E. B. Ziff
Synaptic Anchorage of AMPA Receptors by Cadherins through Neural Plakophilin-Related Arm Protein AMPA Receptor-Binding Protein Complexes
J. Neurosci., August 8, 2007; 27(32): 8505 - 8516.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
M. A. Stiffler, J. R. Chen, V. P. Grantcharova, Y. Lei, D. Fuchs, J. E. Allen, L. A. Zaslavskaia, and G. MacBeath
PDZ Domain Binding Selectivity Is Optimized Across the Mouse Proteome
Science, July 20, 2007; 317(5836): 364 - 369.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
B. A. Appleton, Y. Zhang, P. Wu, J. P. Yin, W. Hunziker, N. J. Skelton, S. S. Sidhu, and C. Wiesmann
Comparative Structural Analysis of the Erbin PDZ Domain and the First PDZ Domain of ZO-1: INSIGHTS INTO DETERMINANTS OF PDZ DOMAIN SPECIFICITY
J. Biol. Chem., August 4, 2006; 281(31): 22312 - 22320.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Zhang, S. Yeh, B. A. Appleton, H. A. Held, P. J. Kausalya, D. C. Y. Phua, W. Lee Wong, L. A. Lasky, C. Wiesmann, W. Hunziker, et al.
Convergent and Divergent Ligand Specificity among PDZ Domains of the LAP and Zonula Occludens (ZO) Families
J. Biol. Chem., August 4, 2006; 281(31): 22299 - 22311.
[Abstract] [Full Text] [PDF]

Home page
 GENES CELLSHome page
S. Takizawa, K. Nagasaka, S. Nakagawa, T. Yano, K. Nakagawa, T. Yasugi, T. Takeuchi, T. Kanda, J. M. Huibregtse, T. Akiyama, et al.
Human scribble, a novel tumor suppressor identified as a target of high-risk HPV E6 for ubiquitin-mediated degradation, interacts with adenomatous polyposis coli
Genes Cells, April 1, 2006; 11(4): 453 - 464.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
P. Dai, W. C. Xiong, and L. Mei
Erbin Inhibits RAF Activation by Disrupting the Sur-8-Ras-Raf Complex
J. Biol. Chem., January 13, 2006; 281(2): 927 - 933.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. McDonald, F. F. Chen, V. Ollendorff, Y. Ogura, S. Marchetto, P. Lecine, J.-P. Borg, and G. Nunez
A Role for Erbin in the Regulation of Nod2-dependent NF-{kappa}B Signaling
J. Biol. Chem., December 2, 2005; 280(48): 40301 - 40309.
[Abstract] [Full Text] [PDF]

Home page
 Plant Cell PhysiolHome page
N. R. Forsthoefel, K. Cutler, M. D. Port, T. Yamamoto, and D. M. Vernon
PIRLs: A Novel Class of Plant Intracellular Leucine-rich Repeat Proteins
Plant Cell Physiol., June 1, 2005; 46(6): 913 - 922.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. Rangwala, F. Banine, J.-P. Borg, and L. S. Sherman
Erbin Regulates Mitogen-activated Protein (MAP) Kinase Activation and MAP Kinase-dependent Interactions between Merlin and Adherens Junction Protein Complexes in Schwann Cells
J. Biol. Chem., March 25, 2005; 280(12): 11790 - 11797.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. Quitsch, K. Berhorster, C. W. Liew, D. Richter, and H.-J. Kreienkamp
Postsynaptic Shank Antagonizes Dendrite Branching Induced by the Leucine-Rich Repeat Protein Densin-180
J. Neurosci., January 12, 2005; 25(2): 479 - 487.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
R. Albertson, C. Chabu, A. Sheehan, and C. Q. Doe
Scribble protein domain mapping reveals a multistep localization mechanism and domains necessary for establishing cortical polarity
J. Cell Sci., December 1, 2004; 117(25): 6061 - 6070.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. C. Miranda, S. R. Joseph, A. S. Yap, R. D. Teasdale, and J. L. Stow
Contextual Binding of p120ctn to E-cadherin at the Basolateral Plasma Membrane in Polarized Epithelia
J. Biol. Chem., October 31, 2003; 278(44): 43480 - 43488.
[Abstract] [Full Text] [PDF]

Home page
 Sci SignalHome page
W. Kolch
Erbin: Sorting Out ErbB2 Receptors or Giving Ras a Break?
Sci. Signal., September 9, 2003; 2003(199): pe37 - pe37.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Biol.Home page
J. Pettitt, E. A. Cox, I. D. Broadbent, A. Flett, and J. Hardin
The Caenorhabditis elegans p120 catenin homologue, JAC-1, modulates cadherin-catenin function during epidermal morphogenesis
J. Cell Biol., July 7, 2003; 162(1): 15 - 22.
[Abstract] [Full Text] [PDF]

Home page
 Sci SignalHome page
C. Nourry, S. G. N. Grant, and J.-P. Borg
PDZ Domain Proteins: Plug and Play!
Sci. Signal., April 22, 2003; 2003(179): re7 - re7.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
M. Hatzfeld, K. J. Green, and H. Sauter
Targeting of p0071 to desmosomes and adherens junctions is mediated by different protein domains
J. Cell Sci., April 1, 2003; 116(7): 1219 - 1233.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
N. J. Skelton, M. F. T. Koehler, K. Zobel, W. L. Wong, S. Yeh, M. T. Pisabarro, J. P. Yin, L. A. Lasky, and S. S. Sidhu
Origins of PDZ Domain Ligand Specificity. STRUCTURE DETERMINATION AND MUTAGENESIS OF THE ERBIN PDZ DOMAIN
J. Biol. Chem., February 21, 2003; 278(9): 7645 - 7654.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
G. Birrane, J. Chung, and J. A. A. Ladias
Novel Mode of Ligand Recognition by the Erbin PDZ Domain
J. Biol. Chem., January 10, 2003; 278(3): 1399 - 1402.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. C. Calkins, B. L. Hoepner, C. M. Law, M. R. Novak, S. V. Setzer, M. Hatzfeld, and A. P. Kowalczyk
The Armadillo Family Protein p0071 Is a VE-cadherin- and Desmoplakin-binding Protein
J. Biol. Chem., January 10, 2003; 278(3): 1774 - 1783.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Z. Huang, M. Zang, W. C. Xiong, Z. Luo, and L. Mei
Erbin Suppresses the MAP Kinase Pathway
J. Biol. Chem., January 3, 2003; 278(2): 1108 - 1114.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Molecular and Cellular Proteomics 
 Journal of Lipid Research   ASBMB Today 
Copyright © 2002 by the American Society for Biochemistry and Molecular Biology.