JBC

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Originally published In Press as doi:10.1074/jbc.M202515200 on August 7, 2002

J. Biol. Chem., Vol. 277, Issue 41, 38635-38646, October 11, 2002
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
277/41/38635    most recent
M202515200v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Huttunen, H. J.
Right arrow Articles by Rauvala, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Huttunen, H. J.
Right arrow Articles by Rauvala, H.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Receptor for Advanced Glycation End Products (RAGE) Signaling Induces CREB-dependent Chromogranin Expression during Neuronal Differentiation*

Henri J. HuttunenDagger , Juha Kuja-Panula, and Heikki Rauvala

From the Programme of Molecular Neurobiology, Institute of Biotechnology and the Department of Biosciences, University of Helsinki, Helsinki FIN-00014, Finland

Receptor for advanced glycation end products (RAGE) mediates neurite outgrowth and cell migration upon stimulation with its ligand, amphoterin. We show here that RAGE-dependent changes in cell morphology are associated with proliferation arrest and changes in gene expression in neuroblastoma cells. Chromogranin B, a component of secretory vesicles in endocrine cells and neurons, was found to be up-regulated by RAGE signaling during differentiation of neuroblastoma cells along with the two other members of the chromogranin family, chromogranin A and secretogranin II. Ligation of RAGE by amphoterin lead to rapid phosphorylation and nuclear localization of cyclic AMP response element-binding protein (CREB), a major regulator of chromogranin expression. Furthermore, inhibition of ERK1/2-Rsk2-dependent CREB phosphorylation efficiently inhibited up-regulation of chromogranin gene expression upon RAGE activation. To further study the effects of RAGE and amphoterin on cellular differentiation, we stimulated embryonic stem cells expressing RAGE or a signaling-deficient mutant of RAGE with amphoterin. Amphoterin was found to promote RAGE-dependent neuronal differentiation of embryonic stem cells characterized by up-regulation of neuronal markers light neurofilament protein and beta -III-tubulin, activation of CREB, and increased expression of chromogranins A and B. These data suggest that RAGE signaling is capable of driving neuronal differentiation involving CREB activation and induction of chromogranin expression.

* This study was supported by grants from the Academy of Finland (Finnish Center of Excellence Program 2000-2005), the Finnish Cancer Society, and the Sigrid Jusélius Foundation.The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

Dagger To whom correspondence should be addressed: P. O. Box 56 (Viikinkaari 5), University of Helsinki FIN-00014, Finland. Tel.: 358-9-19159060; Fax: 358-9-19159068; E-mail: Henri.Huttunen@helsinki.fi.

Copyright © 2002 by The American Society for Biochemistry and Molecular Biology, Inc.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Circ. Res.Home page
N. Smart and P. R. Riley
The Stem Cell Movement
Circ. Res., May 23, 2008; 102(10): 1155 - 1168.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
C. Toth, L. L. Rong, C. Yang, J. Martinez, F. Song, N. Ramji, V. Brussee, W. Liu, J. Durand, M. D. Nguyen, et al.
Receptor for Advanced Glycation End Products (RAGEs) and Experimental Diabetic Neuropathy
Diabetes, April 1, 2008; 57(4): 1002 - 1017.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
P. Pichiule, J. C. Chavez, A. M. Schmidt, and S. J. Vannucci
Hypoxia-inducible Factor-1 Mediates Neuronal Expression of the Receptor for Advanced Glycation End Products following Hypoxia/Ischemia
J. Biol. Chem., December 14, 2007; 282(50): 36330 - 36340.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
E. Leclerc, G. Fritz, M. Weibel, C. W. Heizmann, and A. Galichet
S100B and S100A6 Differentially Modulate Cell Survival by Interacting with Distinct RAGE (Receptor for Advanced Glycation End Products) Immunoglobulin Domains
J. Biol. Chem., October 26, 2007; 282(43): 31317 - 31331.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
F. Riuzzi, G. Sorci, and R. Donato
RAGE Expression in Rhabdomyosarcoma Cells Results in Myogenic Differentiation and Reduced Proliferation, Migration, Invasiveness, and Tumor Growth
Am. J. Pathol., September 1, 2007; 171(3): 947 - 961.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. Kobayashi, H. Kubo, T. Suzuki, K. Ishizawa, M. Yamada, M. He, Y. Yamamoto, H. Yamamoto, H. Sasano, H. Sasaki, et al.
Endogenous Secretory Receptor for Advanced Glycation End Products in Non-Small Cell Lung Carcinoma
Am. J. Respir. Crit. Care Med., January 15, 2007; 175(2): 184 - 189.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
A. Tsung, N. Zheng, G. Jeyabalan, K. Izuishi, J. R. Klune, D. A. Geller, M. T. Lotze, L. Lu, and T. R. Billiar
Increasing numbers of hepatic dendritic cells promote HMGB1-mediated ischemia-reperfusion injury
J. Leukoc. Biol., January 1, 2007; 81(1): 119 - 128.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
F. Limana, A. Germani, A. Zacheo, J. Kajstura, A. Di Carlo, G. Borsellino, O. Leoni, R. Palumbo, L. Battistini, R. Rastaldo, et al.
Exogenous High-Mobility Group Box 1 Protein Induces Myocardial Regeneration After Infarction via Enhanced Cardiac C-Kit+ Cell Proliferation and Differentiation
Circ. Res., October 14, 2005; 97(8): e73 - e83.
[Abstract] [Full Text] [PDF]

Home page
 GlycobiologyHome page
R. Ramasamy, S. J. Vannucci, S. S. D. Yan, K. Herold, S. F. Yan, and A. M. Schmidt
Advanced glycation end products and RAGE: a common thread in aging, diabetes, neurodegeneration, and inflammation
Glycobiology, July 1, 2005; 15(7): 16R - 28R.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
A. Tsung, R. Sahai, H. Tanaka, A. Nakao, M. P. Fink, M. T. Lotze, H. Yang, J. Li, K. J. Tracey, D. A. Geller, et al.
The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion
J. Exp. Med., April 4, 2005; 201(7): 1135 - 1143.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
B. Bartling, H.-S. Hofmann, B. Weigle, R.-E. Silber, and A. Simm
Down-regulation of the receptor for advanced glycation end-products (RAGE) supports non-small cell lung carcinoma
Carcinogenesis, February 1, 2005; 26(2): 293 - 301.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
N. Kalinina, A. Agrotis, Y. Antropova, G. DiVitto, P. Kanellakis, G. Kostolias, O. Ilyinskaya, E. Tararak, and A. Bobik
Increased Expression of the DNA-Binding Cytokine HMGB1 in Human Atherosclerotic Lesions: Role of Activated Macrophages and Cytokines
Arterioscler. Thromb. Vasc. Biol., December 1, 2004; 24(12): 2320 - 2325.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
A. Rouhiainen, J. Kuja-Panula, E. Wilkman, J. Pakkanen, J. Stenfors, R. K. Tuominen, M. Lepantalo, O. Carpen, J. Parkkinen, and H. Rauvala
Regulation of monocyte migration by amphoterin (HMGB1)
Blood, August 15, 2004; 104(4): 1174 - 1182.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
J. H. Li, W. Wang, X. R. Huang, M. Oldfield, A. M. Schmidt, M. E. Cooper, and H. Y. Lan
Advanced Glycation End Products Induce Tubular Epithelial-Myofibroblast Transition through the RAGE-ERK1/2 MAP Kinase Signaling Pathway
Am. J. Pathol., April 1, 2004; 164(4): 1389 - 1397.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. S. Park, D. Svetkauskaite, Q. He, J.-Y. Kim, D. Strassheim, A. Ishizaka, and E. Abraham
Involvement of Toll-like Receptors 2 and 4 in Cellular Activation by High Mobility Group Box 1 Protein
J. Biol. Chem., February 27, 2004; 279(9): 7370 - 7377.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Uchida, K.-i. Ohba, T. Yoshioka, K. Irie, T. Muraki, and Y. Maru
Cellular Carbonyl Stress Enhances the Expression of Plasminogen Activator Inhibitor-1 in Rat White Adipocytes via Reactive Oxygen Species-dependent Pathway
J. Biol. Chem., February 6, 2004; 279(6): 4075 - 4083.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
S. F. Yan, R. Ramasamy, Y. Naka, and A. M. Schmidt
Glycation, Inflammation, and RAGE: A Scaffold for the Macrovascular Complications of Diabetes and Beyond
Circ. Res., December 12, 2003; 93(12): 1159 - 1169.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Biol.Home page
J. Kuja-Panula, M. Kiiltomaki, T. Yamashiro, A. Rouhiainen, and H. Rauvala
AMIGO, a transmembrane protein implicated in axon tract development, defines a novel protein family with leucine-rich repeats
J. Cell Biol., March 17, 2003; 160(6): 963 - 973.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Molecular and Cellular Proteomics 
 Journal of Lipid Research   ASBMB Today 
Copyright © 2002 by the American Society for Biochemistry and Molecular Biology.