|
|
|
|||||||
|
|||||||||
J. Biol. Chem., Vol. 277, Issue 42, 39786-39791, October 18, 2002
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
From the ¶ Audie Murphy Veterans Affairs Medical Center, South
Texas Veterans Health System, San Antonio, Texas 78229, the
Acute and chronic inflammation cause many changes
in total body iron metabolism including the sequestration of iron in
phagocytic cells of the reticuloendothelial system. This change in iron
metabolism contributes to the development of the anemia of
inflammation. MTP1, the duodenal enterocyte basolateral iron exporter,
is also expressed in the cells of the reticuloendothelial system (RES) and is likely to be involved in iron recycling of these cells. In this
study, we use a lipopolysaccharide model of the acute inflammation in
the mouse and demonstrate that MTP1 expression in RES cells of the
spleen, liver, and bone marrow is down-regulated by inflammation. The
down-regulation of splenic expression of MTP1 by inflammation was also
observed in a Leishmania donovani model of chronic
infection. The response of MTP1 to lipopolysaccharide (LPS) requires
signaling through the LPS receptor, Toll-like receptor 4 (TLR4). In
mice lacking TLR4, MTP1 expression is not altered in response to LPS.
In addition, mice lacking tumor necrosis factor-receptor 1a
respond appropriately to LPS with down-regulation of MTP1, despite
hyporesponsiveness to tumor necrosis factor-
Regulation of Reticuloendothelial Iron Transporter MTP1 (Slc11a3)
by Inflammation*
,
, and Department of Cellular and Structural Biology and the
§ Department of Medicine, University of Texas Health Science
Center, San Antonio, Texas 78229, and the National Health and
Environmental Effect Research Laboratory, Environmental Protection
Agency, Chapel Hill, North Carolina 78229
signaling, suggesting
that this cytokine may not be required for the LPS effect. We
hypothesize that the iron sequestration in the RES system that
accompanies inflammation is because of down-regulation of MTP1.
*
This work was supported by a Veterans Affairs Merit Grant
Award (to D. J. H.), National Institutes of Health Grant
R01DK53079 (to D. J. H.), and a grant from the Morrison Trust
(to F. Y.).The costs of publication of this
article were defrayed in part by the
payment of page charges. The article
must therefore be hereby marked
"advertisement" in
accordance with 18 U.S.C. Section
1734 solely to indicate this fact.
Copyright © 2002 by The American Society for Biochemistry and Molecular Biology, Inc.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  I. Theurl, E. Aigner, M. Theurl, M. Nairz, M. Seifert, A. Schroll, T. Sonnweber, L. Eberwein, D. R. Witcher, A. T. Murphy, et al. Regulation of iron homeostasis in anemia of chronic disease and iron deficiency anemia: diagnostic and therapeutic implications Blood, May 21, 2009; 113(21): 5277 - 5286. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. I. Rathore, B. J. Kerr, A. Redensek, R. Lopez-Vales, S. Y. Jeong, P. Ponka, and S. David Ceruloplasmin Protects Injured Spinal Cord from Iron-Mediated Oxidative Damage J. Neurosci., November 26, 2008; 28(48): 12736 - 12747. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. E. Van Zandt, F. B. Sow, W. C. Florence, B. S. Zwilling, A. R. Satoskar, L. S. Schlesinger, and W. P. Lafuse The iron export protein ferroportin 1 is differentially expressed in mouse macrophage populations and is present in the mycobacterial-containing phagosome J. Leukoc. Biol., September 1, 2008; 84(3): 689 - 700. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Tacchini, E. Gammella, C. De Ponti, S. Recalcati, and G. Cairo Role of HIF-1 and NF-{kappa}B Transcription Factors in the Modulation of Transferrin Receptor by Inflammatory and Anti-inflammatory Signals J. Biol. Chem., July 25, 2008; 283(30): 20674 - 20686. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Theurl, M. Theurl, M. Seifert, S. Mair, M. Nairz, H. Rumpold, H. Zoller, R. Bellmann-Weiler, H. Niederegger, H. Talasz, et al. Autocrine formation of hepcidin induces iron retention in human monocytes Blood, February 15, 2008; 111(4): 2392 - 2399. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. De Domenico, D. M. Ward, G. Musci, and J. Kaplan Evidence for the multimeric structure of ferroportin Blood, March 1, 2007; 109(5): 2205 - 2209. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Theurl, V. Mattle, M. Seifert, M. Mariani, C. Marth, and G. Weiss Dysregulated monocyte iron homeostasis and erythropoietin formation in patients with anemia of chronic disease Blood, May 15, 2006; 107(10): 4142 - 4148. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Peyssonnaux, A. S. Zinkernagel, V. Datta, X. Lauth, R. S. Johnson, and V. Nizet TLR4-dependent hepcidin expression by myeloid cells in response to bacterial pathogens Blood, May 1, 2006; 107(9): 3727 - 3732. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Donovan, C. N. Roy, and N. C. Andrews The Ins and Outs of Iron Homeostasis Physiology, April 1, 2006; 21(2): 115 - 123. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Canonne-Hergaux, A. Donovan, C. Delaby, H.-j. Wang, and P. Gros Comparative studies of duodenal and macrophage ferroportin proteins Am J Physiol Gastrointest Liver Physiol, January 1, 2006; 290(1): G156 - G163. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Delaby, N. Pilard, A. S. Goncalves, C. Beaumont, and F. Canonne-Hergaux Presence of the iron exporter ferroportin at the plasma membrane of macrophages is enhanced by iron loading and down-regulated by hepcidin Blood, December 1, 2005; 106(12): 3979 - 3984. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Kasvosve, Z. A. Gomo, K. J Nathoo, P. Matibe, B. Mudenge, M. Loyevsky, and V. R Gordeuk Effect of ferroportin Q248H polymorphism on iron status in African children Am. J. Clinical Nutrition, November 1, 2005; 82(5): 1102 - 1106. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Yang, D. J. Haile, X. Wang, L. A. Dailey, J. G. Stonehuerner, and A. J. Ghio Apical location of ferroportin 1 in airway epithelia and its role in iron detoxification in the lung Am J Physiol Lung Cell Mol Physiol, July 1, 2005; 289(1): L14 - L23. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Wang, M. D. Garrick, F. Yang, L. A. Dailey, C. A. Piantadosi, and A. J. Ghio TNF, IFN-{gamma}, and endotoxin increase expression of DMT1 in bronchial epithelial cells Am J Physiol Lung Cell Mol Physiol, July 1, 2005; 289(1): L24 - L33. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W.-I. Leong and B. Lonnerdal Iron transporters in rat mammary gland: effects of different stages of lactation and maternal iron status Am. J. Clinical Nutrition, February 1, 2005; 81(2): 445 - 453. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. D. Knutson, M. Oukka, L. M. Koss, F. Aydemir, and M. Wessling-Resnick Iron release from macrophages after erythrophagocytosis is up-regulated by ferroportin 1 overexpression and down-regulated by hepcidin PNAS, February 1, 2005; 102(5): 1324 - 1328. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Nemeth, M. S. Tuttle, J. Powelson, M. B. Vaughn, A. Donovan, D. M. Ward, T. Ganz, and J. Kaplan Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization Science, December 17, 2004; 306(5704): 2090 - 2093. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Krijt, M. Vokurka, K.-T. Chang, and E. Necas Expression of Rgmc, the murine ortholog of hemojuvelin gene, is modulated by development and inflammation, but not by iron status or erythropoietin Blood, December 15, 2004; 104(13): 4308 - 4310. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K J H Robson, A T Merryweather-Clarke, E Cadet, V Viprakasit, M G Zaahl, J J Pointon, D J Weatherall, and J Rochette Recent advances in understanding haemochromatosis: a transition state J. Med. Genet., October 1, 2004; 41(10): 721 - 730. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C Gasche, M C E Lomer, I Cavill, and G Weiss Iron, anaemia, and inflammatory bowel diseases Gut, August 1, 2004; 53(8): 1190 - 1197. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Mok, J. Jelinek, S. Pai, B. M. Cattanach, J. T. Prchal, H. Youssoufian, and A. Schumacher Disruption of ferroportin 1 regulation causes dynamic alterations in iron homeostasis and erythropoiesis in polycythaemia mice Development, April 15, 2004; 131(8): 1859 - 1868. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Deicher and W. H. Horl Hepcidin: a molecular link between inflammation and anaemia Nephrol. Dial. Transplant., March 1, 2004; 19(3): 521 - 524. [Full Text] [PDF]
|
|
|
|
|
|
K.-y. Yeh, M. Yeh, and J. Glass Hepcidin regulation of ferroportin 1 expression in the liver and intestine of the rat Am J Physiol Gastrointest Liver Physiol, March 1, 2004; 286(3): G385 - G394. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D. Knutson, M. R. Vafa, D. J. Haile, and M. Wessling-Resnick Iron loading and erythrophagocytosis increase ferroportin 1 (FPN1) expression in J774 macrophages Blood, December 1, 2003; 102(12): 4191 - 4197. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Sarkar, V. Seshadri, N. A. Tripoulas, M. E. Ketterer, and P. L. Fox Role of Ceruloplasmin in Macrophage Iron Efflux during Hypoxia J. Biol. Chem., November 7, 2003; 278(45): 44018 - 44024. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |