| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J. Biol. Chem., Vol. 277, Issue 44, 42380-42385, November 1, 2002
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
From the Division of Cellular Immunology, La Jolla Institute for
Allergy and Immunology, San Diego, California 92121
Members of the tumor necrosis factor (TNF) and
TNF receptor families play important roles in inducing apoptosis and
mediating the inflammatory response. Activated T lymphocytes can
trigger the expression of Fas-ligand on non-lymphoid tissue, such as
intestinal epithelial cells (IEC), and this, in turn, can induce
apoptosis in the T cells. Here, we examine the role of TNF
Tumor Necrosis Factor
Up-regulates Non-lymphoid Fas-ligand
following Superantigen-induced Peripheral Lymphocyte Activation*
,
in
this feedback regulation. Injection of TNF into mice caused a rapid
up-regulation of Fas-ligand mRNA in IEC. TNF-induced activation
of the Fas-ligand promoter in IEC requires NF-
B as this was blocked
by an I-BM super-repressor and by mutation of an NF-B site in
the Fas-ligand promoter. Activation of T cells by antigen induced
Fas-ligand expression in IEC in vivo in wild type, but not
in TNF
/ or TNFR1/ mice. These results define a novel pathway
wherein TNF, produced by activated T cells in the intestine, induce
Fas-ligand expression in IEC. This is the first observation that one
member of the TNF superfamily mediates the regulation of another family member and represents a potential feedback mechanism controlling lymphocyte infiltration and inflammation in the small intestine.
*
This work was supported by National Institutes of Health
Grant AI44828-02 and the Fondation pour la Recherche Medicale (to N. M. D.).The costs of publication of this
article were defrayed in part by the
payment of page charges. The article
must therefore be hereby marked
"advertisement" in
accordance with 18 U.S.C. Section
1734 solely to indicate this fact.
To whom correspondence should be addressed: Div. of Cellular
Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Dr., San Diego, CA 92121. E-mail:
michael@liai.org.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  P.-L. Yao, Y.-C. Lin, P. Sawhney, and J. H. Richburg Transcriptional Regulation of FasL Expression and Participation of sTNF-{alpha} in Response to Sertoli Cell Injury J. Biol. Chem., February 23, 2007; 282(8): 5420 - 5431. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. C. Chen, C. S. Mudge, and D. J. Klumpp Urothelial lesion formation is mediated by TNFR1 during neurogenic cystitis Am J Physiol Renal Physiol, October 1, 2006; 291(4): F741 - F749. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Kiaei, S. Petri, K. Kipiani, G. Gardian, D.-K. Choi, J. Chen, N. Y. Calingasan, P. Schafer, G. W. Muller, C. Stewart, et al. Thalidomide and Lenalidomide Extend Survival in a Transgenic Mouse Model of Amyotrophic Lateral Sclerosis J. Neurosci., March 1, 2006; 26(9): 2467 - 2473. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Wei, K. Chen, G. C. Sharp, and H. Braley-Mullen Fas Ligand Is Required for Resolution of Granulomatous Experimental Autoimmune Thyroiditis J. Immunol., December 15, 2004; 173(12): 7615 - 7621. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Torgler, S. Jakob, E. Ontsouka, U. Nachbur, C. Mueller, D. R. Green, and T. Brunner Regulation of Activation-induced Fas (CD95/Apo-1) Ligand Expression in T Cells by the Cyclin B1/Cdk1 Complex J. Biol. Chem., September 3, 2004; 279(36): 37334 - 37342. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Alikhani, Z. Alikhani, H. He, R. Liu, B. I. Popek, and D. T. Graves Lipopolysaccharides Indirectly Stimulate Apoptosis and Global Induction of Apoptotic Genes in Fibroblasts J. Biol. Chem., December 26, 2003; 278(52): 52901 - 52908. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. M. Droin, M. J. Pinkoski, E. Dejardin, and D. R. Green Egr Family Members Regulate Nonlymphoid Expression of Fas Ligand, TRAIL, and Tumor Necrosis Factor during Immune Responses Mol. Cell. Biol., November 1, 2003; 23(21): 7638 - 7647. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Pinkoski, N. M. Droin, T. Lin, L. Genestier, T. A. Ferguson, and D. R. Green Nonlymphoid Fas ligand in peptide-induced peripheral lymphocyte deletion PNAS, December 10, 2002; 99(25): 16174 - 16179. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
