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Originally published In Press as doi:10.1074/jbc.M204761200 on September 3, 2002

J. Biol. Chem., Vol. 277, Issue 45, 42663-42668, November 8, 2002
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Environmental Stress Causes Oxidative Damage to Plant Mitochondria Leading to Inhibition of Glycine Decarboxylase*

Nicolas L. TaylorDagger , David A. Day§, and A. Harvey Millar§

From the Plant Molecular Biology Group, School of Biomedical and Chemical Sciences, Faculty of Life and Physical Sciences, The University of Western Australia, Crawley, WA 6009, Western Australia, Australia

A cytotoxic product of lipid peroxidation, 4-hydroxy-2-nonenal (HNE), rapidly inhibited glycine, malate/pyruvate, and 2-oxoglutarate-dependent O2 consumption by pea leaf mitochondria. Dose- and time-dependence of inhibition showed that glycine oxidation was the most severely affected with a K0.5 of 30 µM. Several mitochondrial proteins containing lipoic acid moieties differentially lost their reactivity to a lipoic acid antibody following HNE treatment. The most dramatic loss of antigenicity was seen with the 17-kDa glycine decarboxylase complex (GDC) H-protein, which was correlated with the loss of glycine-dependent O2 consumption. Paraquat treatment of pea seedlings induced lipid peroxidation, which resulted in the rapid loss of glycine-dependent respiration and loss of H-protein reactivity with lipoic acid antibodies. Pea plants exposed to chilling and water deficit responded similarly. In contrast, the damage to other lipoic acid-containing mitochondrial enzymes was minor under these conditions. The implication of the acute sensitivity of glycine decarboxylase complex H-protein to lipid peroxidation products is discussed in the context of photorespiration and potential repair mechanisms in plant mitochondria.

* The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

Dagger Recipient of a University of Western Australia postgraduate scholarship.

§ Supported by the Australian Research Council Discovery Program.

To whom correspondence should be addressed. Tel.: 61-8-93807245; Fax: 61-8-93801148; E-mail: hmillar@cyllene.uwa.edu.au.

Copyright © 2002 by The American Society for Biochemistry and Molecular Biology, Inc.
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