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Originally published In Press as doi:10.1074/jbc.M207195200 on August 27, 2002

J. Biol. Chem., Vol. 277, Issue 46, 44202-44207, November 15, 2002
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A Complex of the Srb8, -9, -10, and -11 Transcriptional Regulatory Proteins from Yeast*

Tilman BorggrefeDagger §, Ralph DavisDagger §, Hediye Erdjument-Bromage||, Paul Tempst||, and Roger D. KornbergDagger

From the Dagger  Department of Structural Biology, Stanford University School of Medicine, Stanford, California 94305-5400 and the || Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021

The Srb8, -9, -10, and -11 proteins of yeast have been isolated as a discrete, stoichiometric complex. The isolated complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II at serines 2 and 5. In addition to the previously reported human homologs of Srb10 and 11, we have identified TRAP230/ARC240 and TRAP240/ARC250 as the human homologs of Srb8 and Srb9, showing the entire Srb8/9/10/11 complex is conserved from yeast to humans.

* This work was supported in part by National Institutes of Health Grant GM36659 (to R. D. K.), by a grant from the Human Frontiers Science Program (to R. D. K.), and by National Institutes of Health NCI Cancer Center Core Grant P30 CA08748 (to P. T.).The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

§ These two authors contributed equally to this work.

Recipient of postdoctoral fellowships from the Deutsche Forschungsgemeinschaft, from the Schweizer Nationalfonds, and from the Novartis Foundation. Present address: Dept. for Immunology, University of Ulm, D-89081 Ulm, Germany.

Copyright © 2002 by The American Society for Biochemistry and Molecular Biology, Inc.
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