JBC Transcription and Nuclear Factor Monoclonals

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Originally published In Press as doi:10.1074/jbc.M207831200 on September 17, 2002

J. Biol. Chem., Vol. 277, Issue 47, 44838-44844, November 22, 2002
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
277/47/44838    most recent
M207831200v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kang, S.-J.
Right arrow Articles by Cresswell, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kang, S.-J.
Right arrow Articles by Cresswell, P.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Calnexin, Calreticulin, and ERp57 Cooperate in Disulfide Bond Formation in Human CD1d Heavy Chain*

Suk-Jo Kang and Peter CresswellDagger

From the Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06520-8011

Members of the CD1 family of membrane glycoproteins can present antigenic lipids to T lymphocytes. Like major histocompatibility complex class I molecules, they form a heterodimeric complex of a heavy chain and beta 2-microglobulin (beta 2m) in the endoplasmic reticulum (ER). Binding of lipid antigens, however, takes place in endosomal compartments, similar to class II molecules, and on the plasma membrane. Unlike major histocompatibility complex class I or CD1b molecules, which need beta 2m to exit the ER, CD1d can be expressed on the cell surface as either a free heavy chain or associated with beta 2m. These differences led us to investigate early events of CD1d biosynthesis and maturation and the role of ER chaperones in its assembly. Here we show that CD1d associates in the ER with both calnexin and calreticulin and with the thiol oxidoreductase ERp57 in a manner dependent on glucose trimming of its N-linked glycans. Complete disulfide bond formation in the CD1d heavy chain was substantially impaired if the chaperone interactions were blocked by the glucosidase inhibitors castanospermine or N-butyldeoxynojirimycin. The formation of at least one of the disulfide bonds in the CD1d heavy chain is coupled to its glucose trimming-dependent association with ERp57, calnexin, and calreticulin.

* This work was supported by the Howard Hughes Medical Institute and National Institutes of Health Grant AI23081.The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

Dagger To whom correspondence should be addressed. Tel.: 203-785-5176; Fax: 203-737-1764; E-mail: peter.cresswell@yale.edu.

Copyright © 2002 by The American Society for Biochemistry and Molecular Biology, Inc.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
C. Grillo, C. D'Ambrosio, V. Consalvi, R. Chiaraluce, A. Scaloni, M. Maceroni, M. Eufemi, and F. Altieri
DNA-binding Activity of the ERp57 C-terminal Domain Is Related to a Redox-dependent Conformational Change
J. Biol. Chem., April 6, 2007; 282(14): 10299 - 10310.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
S. K. Dougan, P. Rava, M. M. Hussain, and R. S. Blumberg
MTP regulated by an alternate promoter is essential for NKT cell development
J. Exp. Med., March 19, 2007; 204(3): 533 - 545.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. Kawana, A. J. Quayle, M. Ficarra, J. A. Ibana, L. Shen, Y. Kawana, H. Yang, L. Marrero, S. Yavagal, S. J. Greene, et al.
CD1d Degradation in Chlamydia trachomatis-infected Epithelial Cells Is the Result of Both Cellular and Chlamydial Proteasomal Activity
J. Biol. Chem., March 9, 2007; 282(10): 7368 - 7375.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. Paduraru, L. Spiridon, W. Yuan, G. Bricard, X. Valencia, S. A. Porcelli, P. A. Illarionov, G. S. Besra, S. M. Petrescu, A.-J. Petrescu, et al.
An N-Linked Glycan Modulates the Interaction between the CD1d Heavy Chain and beta2-Microglobulin
J. Biol. Chem., December 29, 2006; 281(52): 40369 - 40378.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
S. K. Dougan, A. Salas, P. Rava, A. Agyemang, A. Kaser, J. Morrison, A. Khurana, M. Kronenberg, C. Johnson, M. Exley, et al.
Microsomal triglyceride transfer protein lipidation and control of CD1d on antigen-presenting cells
J. Exp. Med., August 15, 2005; 202(4): 529 - 539.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
X. Zhu, J. Peng, D. Chen, X. Liu, L. Ye, H. Iijima, K. Kadavil, W. I. Lencer, and R. S. Blumberg
Calnexin and ERp57 Facilitate the Assembly of the Neonatal Fc Receptor for IgG with {beta}2-Microglobulin in the Endoplasmic Reticulum
J. Immunol., July 15, 2005; 175(2): 967 - 976.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. G. Santos, S. J. Powis, and F. A. Arosa
Misfolding of Major Histocompatibility Complex Class I Molecules in Activated T Cells Allows cis-Interactions with Receptors and Signaling Molecules and Is Associated with Tyrosine Phosphorylation
J. Biol. Chem., December 17, 2004; 279(51): 53062 - 53070.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
O. Ben-Zeev and M. H. Doolittle
Maturation of Hepatic Lipase: FORMATION OF FUNCTIONAL ENZYME IN THE ENDOPLASMIC RETICULUM IS THE RATE-LIMITING STEP IN ITS SECRETION
J. Biol. Chem., February 13, 2004; 279(7): 6171 - 6181.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J.-J. Park, S.-J. Kang, A. D. De Silva, A. K. Stanic, G. Casorati, D. L. Hachey, P. Cresswell, and S. Joyce
Lipid-protein interactions: Biosynthetic assembly of CD1 with lipids in the endoplasmic reticulum is evolutionarily conserved
PNAS, January 27, 2004; 101(4): 1022 - 1026.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
G. Negroiu, R. A. Dwek, and S. M. Petrescu
The Inhibition of Early N-Glycan Processing Targets TRP-2 to Degradation in B16 Melanoma Cells
J. Biol. Chem., July 11, 2003; 278(29): 27035 - 27042.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Molecular and Cellular Proteomics 
 Journal of Lipid Research   ASBMB Today 
Copyright © 2002 by the American Society for Biochemistry and Molecular Biology.