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J. Biol. Chem., Vol. 277, Issue 47, 45034-45040, November 22, 2002

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Identification of Ribosomal Proteins Specific to Higher Eukaryotic Organisms^*

Cyril Gueydan^§, Corinne Wauquier, Christelle De Mees^¶, Georges Huez, and Véronique Kruys

From the  Laboratoire de Chimie Biologique and the ^¶ Laboratoire de Biologie du Développement, Institut de Biologie et de Médecine Moléculaires, Université Libre de Bruxelles, 12 rue des Profs. Jeener et Brachet, 6041 Gosselies, Belgium

This report describes the identification of a novel protein named PS1D (Genbank^TM accession number AJ272345), which is composed of an S1-like RNA-binding domain, a (cysteine)×3-(histidine) CCCH-zinc finger, and a very basic carboxyl domain. PS1D is expressed as two isoforms, probably resulting from the alternative splicing of mRNA. The long PS1D isoform differs from the short one by the presence of 48 additional amino acids at its amino-terminal extremity. Analysis of PS1D subcellular distribution by cell fractionation reveals that this protein belongs to the core of the eukaryotic 60S ribosomal subunit. Interestingly, PS1D protein is a highly conserved protein among mammalians as murine, human, and simian PS1D homologues share more than 95% identity. In contrast, no homologous protein is found in lower eukaryotes such as yeast and Caenorhabditis elegans. These observations indicate that PS1D is the first eukaryotic ribosomal protein that is specific to higher eukaryotes.

The nucleotide sequence(s) reported in this paper has been submitted to the GenBank^TM/EBI Data Bank with accession number(s) AJ272345.

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