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J. Biol. Chem., Vol. 277, Issue 47, 45243-45248, November 22, 2002
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From the Mammalian aminoacyl tRNA synthetases form a
macromolecular protein complex with three non-enzymatic cofactors.
Among these factors, p43 is also secreted to work as a cytokine on
endothelial as well as immune cells. Here we investigated the activity
of p43 in angiogenesis and determined the related mediators. It
promoted the migration of endothelial cells at low dose but induced
their apoptosis at high dose. p43 at low concentration activated
extracellular signal-regulating kinase, which resulted in the induction
and activation of matrix metalloproteinase 9. In contrast, p43 at high
concentration activated Jun N-terminal kinase, which mediated apoptosis
of endothelial cells. These results suggest that p43 is a novel
cytokine playing a dose-dependent biphasic role in angiogenesis.
Dose-dependent Biphasic Activity of tRNA
Synthetase-associating Factor, p43, in Angiogenesis*
,,,,
, and**
National Creative Research Initiatives
Center for ARS Network, the § Angiogenesis Research
Laboratory, College of Pharmacy, Seoul National University, Seoul
151-742 and the ¶ National Creative Research
Initiatives Center for Cardiac Regeneration, Postech, Pohang
790-784, Korea
*
This work was supported by a grant from the National
Creative Research Initiatives from the Ministry of Science and
Technology, Korea.The costs of publication of this
article were defrayed in part by the
payment of page charges. The article
must therefore be hereby marked
"advertisement" in
accordance with 18 U.S.C. Section
1734 solely to indicate this fact.
Current address: Graduate School of Biotechnology, Korea
University, Seoul 131-701, Korea.
**
To whom correspondence should be addressed: San 56-1, Shillim-dong, Kwanak-gu, Center for ARS Network, College of
Pharmacy, Seoul National University, Seoul 151-746, Korea. Tel.:
82-2-880-8180; Fax: 82-2-875-2621; E-mail: sungkim@snu.ac.kr.
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