JBC

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Originally published In Press as doi:10.1074/jbc.M206883200 on September 16, 2002

J. Biol. Chem., Vol. 277, Issue 47, 45547-45557, November 22, 2002
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
277/47/45547    most recent
M206883200v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Jono, H.
Right arrow Articles by Li, J.-D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jono, H.
Right arrow Articles by Li, J.-D.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Transforming Growth Factor-beta -Smad Signaling Pathway Cooperates with NF-kappa B to Mediate Nontypeable Haemophilus influenzae-induced MUC2 Mucin Transcription*

Hirofumi JonoDagger , Tsuyoshi ShutoDagger §, Haidong XuDagger , Hirofumi Kai§, David J. LimDagger , James R. Gum Jr., Young S. Kim, Shoji Yamaoka||, Xin-Hua Feng**, and Jian-Dong LiDagger Dagger Dagger

From the Dagger  Gonda Department of Cell and Molecular Biology, House Ear Institute, and Department of Otolaryngology, University of Southern California, Los Angeles, California 90057, the § Department of Molecular Medicine, Kumamoto University, Kumamoto 862-0973, Japan, the  Gastrointestinal Research Laboratory, Veterans Affairs Medical Center and Department of Medicine, University of California, San Francisco, California 94143, the || Department of Molecular Virology, Tokyo Medical and Dental University, Tokyo 113-8519 Japan, and the ** Michael E. DeBakey Department of Surgery and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030

Transforming growth factor-beta (TGF-beta ) and related factors are multifunctional cytokines that regulate diverse cellular processes, including proliferation, differentiation, apoptosis, and immune response. The involvement of TGF-beta receptor-mediated signaling in bacteria-induced up-regulation of mucin, a primary innate defensive response for mammalian airways, however, still remains unknown. Here, we report that the bacterium nontypeable Haemophilus influenzae (NTHi), an important human respiratory pathogen, utilizes the TGF-beta -Smad signaling pathway together with the TLR2-MyD88-TAK1-NIK-IKKbeta /gamma -Ikappa Balpha pathway to mediate NF-kappa B-dependent MUC2 mucin transcription. The NTHi-induced TGF-beta receptor Type II phosphorylation occurred at as early as 5 min. Pretreatment of NTHi with TGF-beta neutralization antibody reduced up-regulation of MUC2 transcription. Moreover, functional cooperation of NF-kappa B p65/p50 with Smad3/4 appears to positively mediate NF-kappa B-dependent MUC2 transcription. These data are the first to demonstrate the involvement of TGF-beta receptor-mediated signaling in bacteria-induced up-regulation of mucin transcription, bring insights into the novel role of TGF-beta signaling in bacterial pathogenesis, and may lead to new therapeutic intervention of NTHi infections.

* This work was supported in part by grants from the National Institutes of Health (RO1-DC04562) (to J. D. L.), CA24321 (to Y. S. K. and J. G.) and GM63773 (to X.-H. F.), the Department of Veterans Affairs Medical Research Service (to J. G. and Y. S. K.), American Cancer Society Research Project Grant RPG-00214-01-CCG (to X.-H. F.), and the Henry L. Guenther Foundation (to D. J. L. and J. D. L.).The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

Dagger Dagger To whom correspondence should be addressed: the Gonda Dept. of Cell and Molecular Biology, House Ear Inst., University of Southern California, 2100 W. 3rd St., Los Angeles, CA 90057. Tel.: 213-273-8083; Fax: 213-273-8088; E-mail: jdli@hei.org.

Copyright © 2002 by The American Society for Biochemistry and Molecular Biology, Inc.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Am. J. Pathol.Home page
C. A. Wu, J. J. Peluso, J. D. Shanley, L. Puddington, and R. S. Thrall
Murine Cytomegalovirus Influences Foxj1 Expression, Ciliogenesis, and Mucus Plugging in Mice with Allergic Airway Disease
Am. J. Pathol., March 1, 2008; 172(3): 714 - 724.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. Beisswenger, C. B. Coyne, M. Shchepetov, and J. N. Weiser
Role of p38 MAP Kinase and Transforming Growth Factor-beta Signaling in Transepithelial Migration of Invasive Bacterial Pathogens
J. Biol. Chem., September 28, 2007; 282(39): 28700 - 28708.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
H. W. J. Young, O. W. Williams, D. Chandra, L. K. Bellinghausen, G. Perez, A. Suarez, M. J. Tuvim, M. G. Roy, S. N. Alexander, S. J. Moghaddam, et al.
Central Role of Muc5ac Expression in Mucous Metaplasia and Its Regulation by Conserved 5' Elements
Am. J. Respir. Cell Mol. Biol., September 1, 2007; 37(3): 273 - 290.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
S. K. Moon, J.-I. Woo, H.-Y. Lee, R. Park, J. Shimada, H. Pan, R. Gellibolian, and D. J. Lim
Toll-Like Receptor 2-Dependent NF-{kappa}B Activation Is Involved in Nontypeable Haemophilus influenzae-Induced Monocyte Chemotactic Protein 1 Up-Regulation in the Spiral Ligament Fibrocytes of the Inner Ear
Infect. Immun., July 1, 2007; 75(7): 3361 - 3372.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
Q. Wu, R. J. Martin, J. G. Rino, S. Jeyaseelan, R. Breed, and H. W. Chu
A deficient TLR2 signaling promotes airway mucin production in Mycoplasma pneumoniae-infected allergic mice
Am J Physiol Lung Cell Mol Physiol, May 1, 2007; 292(5): L1064 - L1072.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
U. Ha, J. H. Lim, H. Jono, T. Koga, A. Srivastava, R. Malley, G. Pages, J. Pouyssegur, and J.-D. Li
A Novel Role for I{kappa}B Kinase (IKK) {alpha} and IKKbeta in ERK-Dependent Up-Regulation of MUC5AC Mucin Transcription by Streptococcus pneumoniae
J. Immunol., February 1, 2007; 178(3): 1736 - 1747.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
J. A. Voynow, S. J. Gendler, and M. C. Rose
Regulation of Mucin Genes in Chronic Inflammatory Airway Diseases
Am. J. Respir. Cell Mol. Biol., June 1, 2006; 34(6): 661 - 665.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
O. W. Williams, A. Sharafkhaneh, V. Kim, B. F. Dickey, and C. M. Evans
Airway Mucus: From Production to Secretion
Am. J. Respir. Cell Mol. Biol., May 1, 2006; 34(5): 527 - 536.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
M. C. Rose and J. A. Voynow
Respiratory Tract Mucin Genes and Mucin Glycoproteins in Health and Disease
Physiol Rev, January 1, 2006; 86(1): 245 - 278.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. Yoshida, H. Jono, H. Kai, and J.-D. Li
The Tumor Suppressor Cylindromatosis (CYLD) Acts as a Negative Regulator for Toll-like Receptor 2 Signaling via Negative Cross-talk with TRAF6 and TRAF7
J. Biol. Chem., December 9, 2005; 280(49): 41111 - 41121.
[Abstract] [Full Text] [PDF]

Home page
 Appl. Environ. Microbiol.Home page
M. S. Goodson, M. Kojadinovic, J. V. Troll, T. E. Scheetz, T. L. Casavant, M. B. Soares, and M. J. McFall-Ngai
Identifying Components of the NF-{kappa}B Pathway in the Beneficial Euprymna scolopes-Vibrio fischeri Light Organ Symbiosis
Appl. Envir. Microbiol., November 1, 2005; 71(11): 6934 - 6946.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
F. Mikami, H. Gu, H. Jono, A. Andalibi, H. Kai, and J.-D. Li
Epidermal Growth Factor Receptor Acts as a Negative Regulator for Bacterium Nontypeable Haemophilus influenzae-induced Toll-like Receptor 2 Expression via an Src-dependent p38 Mitogen-activated Protein Kinase Signaling Pathway
J. Biol. Chem., October 28, 2005; 280(43): 36185 - 36194.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. M. Lora, D. M. Zhang, S. M. Liao, T. Burwell, A. M. King, P. A. Barker, L. Singh, M. Keaveney, J. Morgenstern, J. C. Gutierrez-Ramos, et al.
Tumor Necrosis Factor-{alpha} Triggers Mucus Production in Airway Epithelium through an I{kappa}B Kinase {beta}-dependent Mechanism
J. Biol. Chem., October 28, 2005; 280(43): 36510 - 36517.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T. Shimizu, Y. Kida, and K. Kuwano
A Dipalmitoylated Lipoprotein from Mycoplasma pneumoniae Activates NF-{kappa}B through TLR1, TLR2, and TLR6
J. Immunol., October 1, 2005; 175(7): 4641 - 4646.
[Abstract] [Full Text] [PDF]

Home page
 JPEN J Parenter Enteral NutrHome page
E. J. Schiffrin, M. E. Yousfi, M. Faure, L. Combaret, A. Donnet, S. Blum, C. Obled, and D. Breuille
Milk Casein-Based Diet Containing TGF-{beta} Controls the Inflammatory Reaction in the HLA-B27 Transgenic Rat Model
JPEN J Parenter Enteral Nutr, July 1, 2005; 29(4_suppl): S141 - S150.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H. W. Chu, S. Jeyaseelan, J. G. Rino, D. R. Voelker, R. B. Wexler, K. Campbell, R. J. Harbeck, and R. J. Martin
TLR2 Signaling Is Critical for Mycoplasma pneumoniae-Induced Airway Mucin Expression
J. Immunol., May 1, 2005; 174(9): 5713 - 5719.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
H. W. Chu, S. Balzar, G. J. Seedorf, J. Y. Westcott, J. B. Trudeau, P. Silkoff, and S. E. Wenzel
Transforming Growth Factor-{beta}2 Induces Bronchial Epithelial Mucin Expression in Asthma
Am. J. Pathol., October 1, 2004; 165(4): 1097 - 1106.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
T. Watanabe, H. Jono, J. Han, D. J. Lim, and J.-D. Li
Synergistic activation of NF-{kappa}B by nontypeable Haemophilus influenzae and tumor necrosis factor {alpha}
PNAS, March 9, 2004; 101(10): 3563 - 3568.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
A. Moustakas and C.-H. Heldin
Ecsit-ement on the crossroads of Toll and BMP signal transduction
Genes & Dev., December 1, 2003; 17(23): 2855 - 2859.
[Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. Jono, H. Xu, H. Kai, D. J. Lim, Y. S. Kim, X.-H. Feng, and J.-D. Li
Transforming Growth Factor-{beta}-Smad Signaling Pathway Negatively Regulates Nontypeable Haemophilus influenzae-induced MUC5AC Mucin Transcription via Mitogen-activated Protein Kinase (MAPK) Phosphatase-1-dependent Inhibition of p38 MAPK
J. Biol. Chem., July 18, 2003; 278(30): 27811 - 27819.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Molecular and Cellular Proteomics 
 Journal of Lipid Research   ASBMB Today 
Copyright © 2002 by the American Society for Biochemistry and Molecular Biology.