JBC

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Originally published In Press as doi:10.1074/jbc.M203654200 on September 6, 2002

J. Biol. Chem., Vol. 277, Issue 48, 46493-46503, November 29, 2002
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
277/48/46493    most recent
M203654200v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kumar, A.
Right arrow Articles by Boriek, A. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kumar, A.
Right arrow Articles by Boriek, A. M.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Distinct Signaling Pathways Are Activated in Response to Mechanical Stress Applied Axially and Transversely to Skeletal Muscle Fibers*

Ashok Kumar, Imran Chaudhry, Michael B. Reid, and Aladin M. BoriekDagger

From the Department of Medicine, Baylor College of Medicine, Houston, Texas 77030

In the diaphragm muscle we tested the hypothesis that MAP kinase signaling pathways are activated by mechanical stress and such signaling pathways are dependent on the direction in which mechanical stress is applied. Although equal magnitudes of mechanical stress were applied axially and transversely a greater level of activation of ERK1/2, p38, Raf-1, p90 RSK, Elk-1, and the DNA binding activity of AP-1 transcription factor was produced when the muscle was stretched transversely than when stretched axially. A significant up-regulation in protein tyrosine phosphorylation was observed in axially or transversely loaded diaphragm muscles and the activation of ERK1/2 was completely inhibited by genistein (protein-tyrosine kinase inhibitor). Pretreatment of muscles with wortmannin (phosphoinositide 3-kinase inhibitor), TMB-8 (antagonist of intracellular calcium release), GF109203X (PKC inhibitor), or PD98059 (MEK1/2 inhibitor) blocked the activation of ERK1/2 kinases in response to axial but not to transverse loading. On the other hand, pretreatment of muscles with protein kinase A inhibitors H-7 and KT5720 completely suppressed the activation of ERK1/2 in response to transverse loading only. Taken together with the alterations of MAP kinases and the findings of elevations of downstream transcription targets, our data are consistent with two distinct MAP kinase signal transduction pathways in response to mechanical stress.

* This work was supported by National Institutes of Health Grants RO1-63134 and RO1-46230 (to A. B.) and HL45721 (to M. B. R.).The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

Dagger To whom correspondence should be addressed: Pulmonary and Critical Care, Suite 520B, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030. Fax: 713-798-3619; E-mail: boriek@bcm.tmc.edu.

Copyright © 2002 by The American Society for Biochemistry and Molecular Biology, Inc.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
A. K. Srivastava, X. Qin, N. Wedhas, M. Arnush, T. A. Linkhart, R. B. Chadwick, and A. Kumar
Tumor Necrosis Factor-{alpha} Augments Matrix Metalloproteinase-9 Production in Skeletal Muscle Cells through the Activation of Transforming Growth Factor- -activated Kinase 1 (TAK1)-dependent Signaling Pathway
J. Biol. Chem., November 30, 2007; 282(48): 35113 - 35124.
[Abstract] [Full Text] [PDF]

Home page
 Exp PhysiolHome page
K. M. Rice, D. H. Desai, D. L. Preston, P. S. Wehner, and E. R. Blough
Vascular: Uniaxial stretch-induced regulation of mitogen-activated protein kinase, Akt and p70 S6 kinase in the ageing Fischer 344 x Brown Norway rat aorta
Exp Physiol, September 1, 2007; 92(5): 963 - 970.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. Dogra, S. L. Hall, N. Wedhas, T. A. Linkhart, and A. Kumar
Fibroblast Growth Factor Inducible 14 (Fn14) Is Required for the Expression of Myogenic Regulatory Factors and Differentiation of Myoblasts into Myotubes: EVIDENCE FOR TWEAK-INDEPENDENT FUNCTIONS OF Fn14 DURING MYOGENESIS
J. Biol. Chem., May 18, 2007; 282(20): 15000 - 15010.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
T. Shen, Z. Cseresnyes, Y. Liu, W. R. Randall, and M. F. Schneider
Regulation of the nuclear export of the transcription factor NFATc1 by protein kinases after slow fibre type electrical stimulation of adult mouse skeletal muscle fibres
J. Physiol., March 1, 2007; 579(2): 535 - 551.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. Dogra, H. Changotra, S. Mohan, and A. Kumar
Tumor Necrosis Factor-like Weak Inducer of Apoptosis Inhibits Skeletal Myogenesis through Sustained Activation of Nuclear Factor-{kappa}B and Degradation of MyoD Protein
J. Biol. Chem., April 14, 2006; 281(15): 10327 - 10336.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
E. R. Barton
Impact of sarcoglycan complex on mechanical signal transduction in murine skeletal muscle
Am J Physiol Cell Physiol, February 1, 2006; 290(2): C411 - C419.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
N. Wedhas, H. J. Klamut, C. Dogra, A. K. Srivastava, S. Mohan, and A. Kumar
Inhibition of mechanosensitive cation channels inhibits myogenic differentiation by suppressing the expression of myogenic regulatory factors and caspase-3 activity
FASEB J, December 1, 2005; 19(14): 1986 - 1997.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
H. Shiratsuchi and M. D. Basson
Activation of p38 MAPK{alpha} by extracellular pressure mediates the stimulation of macrophage phagocytosis by pressure
Am J Physiol Cell Physiol, May 1, 2005; 288(5): C1083 - C1093.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
M. A. Griffin, H. Feng, M. Tewari, P. Acosta, M. Kawana, H. L. Sweeney, and D. E. Discher
{gamma}-Sarcoglycan deficiency increases cell contractility, apoptosis and MAPK pathway activation but does not affect adhesion
J. Cell Sci., April 1, 2005; 118(7): 1405 - 1416.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
J. N. Dentel, S. G. Blanchard, D. P. Ankrapp, L. R. McCabe, and R. W. Wiseman
Inhibition of cross-bridge formation has no effect on contraction-associated phosphorylation of p38 MAPK in mouse skeletal muscle
Am J Physiol Cell Physiol, April 1, 2005; 288(4): C824 - C830.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
T. A. Hornberger, D. D. Armstrong, T. J. Koh, T. J. Burkholder, and K. A. Esser
Intracellular signaling specificity in response to uniaxial vs. multiaxial stretch: implications for mechanotransduction
Am J Physiol Cell Physiol, January 1, 2005; 288(1): C185 - C194.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
A. KUMAR, R. MURPHY, P. ROBINSON, L. WEI, and A. M. BORIEK
Cyclic mechanical strain inhibits skeletal myogenesis through activation of focal adhesion kinase, Rac-1 GTPase, and NF-{kappa}B transcription factor
FASEB J, October 1, 2004; 18(13): 1524 - 1535.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
V. Staniforth, S.-Y. Wang, L.-F. Shyur, and N.-S. Yang
Shikonins, Phytocompounds from Lithospermum erythrorhizon, Inhibit the Transcriptional Activation of Human Tumor Necrosis Factor {alpha} Promoter in Vivo
J. Biol. Chem., February 13, 2004; 279(7): 5877 - 5885.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
A. KUMAR, N. KHANDELWAL, R. MALYA, M. B. REID, and A. M. BORIEK
Loss of dystrophin causes aberrant mechanotransduction in skeletal muscle fibers
FASEB J, January 1, 2004; 18(1): 102 - 113.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
F. Haddad and G. R. Adams
Inhibition of MAP/ERK kinase prevents IGF-I-induced hypertrophy in rat muscles
J Appl Physiol, January 1, 2004; 96(1): 203 - 210.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
A. KUMAR, S. LNU, R. MALYA, D. BARRON, J. MOORE, D. B. CORRY, and A. M. BORIEK
Mechanical stretch activates nuclear factor-kappaB, activator protein-1, and mitogen-activated protein kinases in lung parenchyma: implications in asthma
FASEB J, October 1, 2003; 17(13): 1800 - 1811.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. R. Jannapureddy, N. D. Patel, W. Hwang, and A. M. Boriek
Genetic Models in Applied Physiology: Selected Contribution: Merosin deficiency leads to alterations in passive and active skeletal muscle mechanics
J Appl Physiol, June 1, 2003; 94(6): 2524 - 2533.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Kumar, A. J. Knox, and A. M. Boriek
CCAAT/Enhancer-binding Protein and Activator Protein-1 Transcription Factors Regulate the Expression of Interleukin-8 through the Mitogen-activated Protein Kinase Pathways in Response to Mechanical Stretch of Human Airway Smooth Muscle Cells
J. Biol. Chem., May 23, 2003; 278(21): 18868 - 18876.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Molecular and Cellular Proteomics 
 Journal of Lipid Research   ASBMB Today 
Copyright © 2002 by the American Society for Biochemistry and Molecular Biology.