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J. Biol. Chem., Vol. 277, Issue 49, 46993-46997, December 6, 2002
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From the Department of Molecular and Cellular Biochemistry,
Chandler Medical Center, University of Kentucky,
Lexington, Kentucky 40536
In addition to being the universal carbon and
energy source, glucose also regulates gene expression in many
organisms. In the yeast Saccharomyces cerevisiae glucose
regulates gene expression via two different pathways known as the
glucose repression and glucose induction pathways. The signal for
glucose induction of hexose transporter (HXT) genes is
generated via two glucose-transporter like molecules, Snf3 and Rgt2. A
strain lacking both sensors is unable to induce HXT gene
expression and is defective in glucose uptake. The snf3
rgt2 double mutant is also defective in glucose repression of
transcription, raising the possibility that Snf3 and Rgt2 are also
involved in generating the glucose repression signal. In this report, I
show that induction and repression of gene expression by glucose in
yeast is regulated by two independent signals. While the signal for
induction of HXT gene expression is generated by Snf3 and
Rgt2 glucose receptors, the repression signal requires the uptake and
metabolism of glucose. In addition, the glucose induction of the
HXT genes is required for repression of gene expression by
glucose. Therefore the glucose repression defect of the snf3
rgt2 strain is indirect and is due to the lack of glucose uptake
in this double mutant.
Two Different Signals Regulate Repression and Induction of
Gene Expression by Glucose*
*
The costs of publication of this
article were defrayed in part by the
payment of page charges. The article
must therefore be hereby marked
"advertisement" in
accordance with 18 U.S.C. Section
1734 solely to indicate this fact.
To whom correspondence should be addressed: Dept. of Molecular and
Cellular Biochemistry, University of Kentucky, College of Medicine, 800 Rose St., MN 608, Lexington, KY 40536. Tel.: 859-257-4821; Fax:
859-323-1037; E-mail: sozcan@pop.uky.edu.
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