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Originally published In Press as doi:10.1074/jbc.M203159200 on October 2, 2002

J. Biol. Chem., Vol. 277, Issue 49, 47870-47877, December 6, 2002
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Parkin Accumulation in Aggresomes Due to Proteasome Impairment*

Eunsung Junn, Sang Seop Lee, Unsun T. Suhr, and M. Maral MouradianDagger

From the Genetic Pharmacology Unit, Experimental Therapeutics Branch, NINDS, National Institutes of Health, Bethesda, Maryland 20892-1406

Parkinson's disease (PD) is characterized by loss of dopaminergic neurons in the substantia nigra and by the presence of ubiquitinated cytoplasmic inclusions known as Lewy bodies. alpha -Synuclein and Parkin are two of the proteins associated with inherited forms of PD and are found in Lewy bodies. Whereas numerous reports indicate the tendency of alpha -synuclein to aggregate both in vitro and in vivo, no information is available about similar physical properties for Parkin. Here we show that overexpression of Parkin in the presence of proteasome inhibitors leads to the formation of aggresome-like perinuclear inclusions. These eosinophilic inclusions share many characteristics with Lewy bodies, including a core and halo organization, immunoreactivity to ubiquitin, alpha -synuclein, synphilin-1, Parkin, molecular chaperones, and proteasome subunit as well as staining of some with thioflavin S. We propose that the process of Lewy body formation may be akin to that of aggresome-like structures. The tendency of wild-type Parkin to aggregate and form inclusions may have implications for the pathogenesis of sporadic PD.

* The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

Dagger To whom correspondence should be addressed: NINDS, National Institutes of Health, 10 Center Dr., MSC 1406, Bethesda, MD 20892-1406. Tel.: 301-496-7872; Fax: 301-496-6609; E-mail: MouradianM@ ninds.nih.gov.

Copyright © 2002 by The American Society for Biochemistry and Molecular Biology, Inc.
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