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Originally published In Press as doi:10.1074/jbc.M209329200 on October 8, 2002

J. Biol. Chem., Vol. 277, Issue 50, 48359-48365, December 13, 2002
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Impaired Proliferation and Survival of Activated B Cells in Transgenic Mice That Express a Dominant-negative cAMP-response Element-binding Protein Transcription Factor in B Cells*

Chun-yi Zhang, Yu-Ling Wu, and Linda M. BoxerDagger

From the Center for Molecular Biology in Medicine, Veterans Affairs Palo Alto Health Care System and the Department of Medicine, Stanford University School of Medicine, Stanford, California 94305

The cAMP-response element-binding protein (CREB) is activated by phosphorylation on serine 133 and mediates the proliferative response to a number of different signals. A mutant CREB with a serine to alanine substitution at position 133 (CREBM1) functions as a dominant-negative inhibitor. Transgenic mice that express the dominant-negative CREB protein in B lymphocytes were developed as a means to study the effects of the inhibition of CREB function on B-cell proliferation and survival. We have shown previously that CREB up-regulates Bcl-2 expression in B cells in response to activation signals. B cells from CREBM1 transgenic mice expressed lower levels of Bcl-2 with and without stimulation. Proliferation of B cells from the transgenic mice was impaired in part by lack of induction of activator protein 1 (AP1) transcription factors. B cells from the transgenic mice were more susceptible to induction of apoptosis with several different agents, consistent with the decreased expression of Bcl-2. These studies demonstrate that B-cell activation requires phosphorylation of CREB for the proliferative response and to protect against activation-induced apoptosis.

* This work was supported by United States Public Health Service Grant CA56764 from the NCI, National Institutes of Health.The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

Dagger To whom correspondence should be addressed: Hematology, CCSR 1155, Stanford University School of Medicine, Stanford, CA 94305-5156. Tel.: 650-849-0551; Fax: 650-858-3982; E-mail: lboxer@stanford.edu.

Copyright © 2002 by The American Society for Biochemistry and Molecular Biology, Inc.
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