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J. Biol. Chem., Vol. 277, Issue 50, 48842-48848, December 13, 2002
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From the BRG-1, a component of the human SWI/SNF complex,
either activates or represses cellular promoters by modulating
chromatin structure via the formation of a multiple polypeptide
complex. Human papillomavirus E7 binds and destabilizes pRb,
resulting in the blockage of G1 arrest in the cell
cycle. We show here that the high-risk human papillomavirus E7 protein
group binds BRG-1 and modulates repression of the c-fos
promoter mediated by this protein. In addition, both wild-type and Rb
binding-defective E7 proteins abolish flat cell formation by BRG-1 in
SW13 cells, whereas E7 COOH-terminal mutants do not affect this
process. BRG-1-triggered repression of the c-fos promoter
is sensitive to trichostatin A. We further establish that BRG-1
contains an activation domain and a trichostatin A-sensitive repression
domain. These results collectively suggest that the viral oncogene E7
targets both pRb and BRG-1 via protein-protein interactions, resulting
in the deregulation of host cell cycle control.
The Viral Oncogene Human Papillomavirus E7
Deregulates Transcriptional Silencing by Brm-related Gene 1 via
Molecular Interactions*
,,,
Department of Biological Sciences, Korea
Advanced Institute of Science and Technology, Daejeon 305-701, Korea,
the § Department of Bioscience and Biotechnology, Hankuk
University of Foreign Studies, Yongin-Shi, Kyongki-Do, 449-791, Korea,
and the ¶ Department of Food and Nutrition, Hannam University,
Daejeon 306-791, Korea
*
This work was supported in part by the National Research
Laboratory Program of the Korea Institute of Science & Technology Evaluation and Planning (KISTEP), the Molecular Medicine Research Group
Program of KISTEP through the Biomedical Research Center at Korea
Advanced Institute of Science and Technology, and the Korea Science and
Engineering Foundation through the Protein Network Research Center at
Yonsei University.The costs of publication of this
article were defrayed in part by the
payment of page charges. The article
must therefore be hereby marked
"advertisement" in accordance with 18 U.S.C. Section
1734 solely to indicate this fact.
To whom correspondence should be addressed. Tel.:
82-42-869-2630; Fax: 82-42-869-5630; E-mail:
jchoe@mail.kaist.ac.kr.
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