JBC Connect with Cosmo for Collagen Detection

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Originally published In Press as doi:10.1074/jbc.M207584200 on September 27, 2002

J. Biol. Chem., Vol. 277, Issue 51, 49127-49133, December 20, 2002
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
277/51/49127    most recent
M207584200v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hurbin, A.
Right arrow Articles by Favrot, M.-C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hurbin, A.
Right arrow Articles by Favrot, M.-C.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Inhibition of Apoptosis by Amphiregulin via an Insulin-like Growth Factor-1 Receptor-dependent Pathway in Non-small Cell Lung Cancer Cell Lines*

Amandine HurbinDagger , Laurence DubrezDagger §, Jean-Luc Coll, and Marie-Christine Favrot

From the Groupe de Recherche sur le Cancer du Poumon, INSERM-EMI 9924, Institut Albert Bonniot, La Tronche 38706 Cedex, France

Several abnormalities in the insulin-like growth factor-1 (IGF1) and erbB receptors pathways stimulate the growth and survival of lung cancer cells, but their mechanisms of action and cooperation are poorly understood. In this report, we have identified a new mechanism of apoptosis inhibition by amphiregulin through an IGF1-dependent survival pathway in non-small cell lung cancer (NSCLC) cells: amphiregulin activates the IGF1 receptor that in turn induces the secretion of amphiregulin and IGF1. In the absence of serum, the NSCLC cell line H358 resists apoptosis and secretes factors protecting the NSCLC cell line H322 from serum deprivation apoptosis. IGF1 receptor inhibitor AG1024 as well as epidermal growth factor receptor inhibitors AG556 and ZD1839 restore apoptosis in H322 cells cultured in H358-conditioned medium. Accordingly, the anti-apoptotic activity of H358-conditioned medium is completely abolished after incubation with anti-amphiregulin neutralizing antibody and only partially with anti-IGF1 neutralizing antibody. H358-conditioned medium and amphiregulin induce IGF1 receptor phosphorylation in H322 cells, which is prevented by anti-amphiregulin neutralizing antibody but not by AG556 or ZD1839. H358 cells secrete a high level of amphiregulin that, in combination with IGF1, prevents serum deprivation apoptosis. Finally, IGF1 receptor inhibitor blocks amphiregulin and IGF1 release by H358 cells.

* This work was supported by grants and research fellowships from Association pour la Recherche contre le Cancer.The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

Dagger Both authors contributed equally to this work.

§ Present address: INSERM U517, Faculté de Médecine/Pharmacie, 7 boulevard Jeanne d'Arc, Dijon 21033 cedex, France.

To whom correspondence should be addressed: Tel.: 33-4-76-76-54-84; Fax: 33-4-76-76-56-64; E-mail: MCFavrot@chu-grenoble.fr.

Copyright © 2002 by The American Society for Biochemistry and Molecular Biology, Inc.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Toxicol PatholHome page
N. Wakamatsu, J. B. Collins, J. S. Parker, M. Tessema, N. P. Clayton, T.-V. T. Ton, H.-H. L. Hong, S. Belinsky, T. R. Devereux, R. C. Sills, et al.
Gene Expression Studies Demonstrate that the K-ras/Erk MAP Kinase Signal Transduction Pathway and Other Novel Pathways Contribute to the Pathogenesis of Cumene-induced Lung Tumors
Toxicol Pathol, July 1, 2008; 36(5): 743 - 752.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
A. K. Chakraborty, K. Liang, and M. P. DiGiovanna
Co-Targeting Insulin-Like Growth Factor I Receptor and HER2: Dramatic Effects of HER2 Inhibitors on Nonoverexpressing Breast Cancer
Cancer Res., March 1, 2008; 68(5): 1538 - 1545.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
L. Nilsson, P. Eden, E. Olsson, R. Mansson, I. Astrand-Grundstrom, B. Strombeck, K. Theilgaard-Monch, K. Anderson, R. Hast, E. Hellstrom-Lindberg, et al.
The molecular signature of MDS stem cells supports a stem-cell origin of 5q myelodysplastic syndromes
Blood, October 15, 2007; 110(8): 3005 - 3014.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
V. Pinto-Plata, J. Toso, K. Lee, D. Park, J. Bilello, H. Mullerova, M. M De Souza, R. Vessey, and B. Celli
Profiling serum biomarkers in patients with COPD: associations with clinical parameters
Thorax, July 1, 2007; 62(7): 595 - 601.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
K. Shinagawa, J. A. Martin, V. A. Ploplis, and F. J. Castellino
Coagulation Factor Xa Modulates Airway Remodeling in a Murine Model of Asthma
Am. J. Respir. Crit. Care Med., January 15, 2007; 175(2): 136 - 143.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
J. Castillo, E. Erroba, M. J. Perugorria, M. Santamaria, D. C. Lee, J. Prieto, M. A. Avila, and C. Berasain
Amphiregulin contributes to the transformed phenotype of human hepatocellular carcinoma cells.
Cancer Res., June 15, 2006; 66(12): 6129 - 6138.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
S. Kalyankrishna and J. R. Grandis
Epidermal Growth Factor Receptor Biology in Head and Neck Cancer
J. Clin. Oncol., June 10, 2006; 24(17): 2666 - 2672.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
H. Bayram, K. Ito, R. Issa, M. Ito, M. Sukkar, and K. F. Chung
Regulation of human lung epithelial cell numbers by diesel exhaust particles
Eur. Respir. J., April 1, 2006; 27(4): 705 - 713.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. M. Knowlden, I. R. Hutcheson, D. Barrow, J. M. W. Gee, and R. I. Nicholson
Insulin-Like Growth Factor-I Receptor Signaling in Tamoxifen-Resistant Breast Cancer: A Supporting Role to the Epidermal Growth Factor Receptor
Endocrinology, November 1, 2005; 146(11): 4609 - 4618.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
N. Ishikawa, Y. Daigo, A. Takano, M. Taniwaki, T. Kato, S. Hayama, H. Murakami, Y. Takeshima, K. Inai, H. Nishimura, et al.
Increases of Amphiregulin and Transforming Growth Factor-{alpha} in Serum as Predictors of Poor Response to Gefitinib among Patients with Advanced Non-Small Cell Lung Cancers
Cancer Res., October 15, 2005; 65(20): 9176 - 9184.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Hurbin, J.-L. Coll, L. Dubrez-Daloz, B. Mari, P. Auberger, C. Brambilla, and M.-C. Favrot
Cooperation of Amphiregulin and Insulin-like Growth Factor-1 Inhibits Bax- and Bad-mediated Apoptosis via a Protein Kinase C-dependent Pathway in Non-small Cell Lung Cancer Cells
J. Biol. Chem., May 20, 2005; 280(20): 19757 - 19767.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
S. Kakiuchi, Y. Daigo, N. Ishikawa, C. Furukawa, T. Tsunoda, S. Yano, K. Nakagawa, T. Tsuruo, N. Kohno, M. Fukuoka, et al.
Prediction of sensitivity of advanced non-small cell lung cancers to gefitinib (Iressa, ZD1839)
Hum. Mol. Genet., December 15, 2004; 13(24): 3029 - 3043.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
C. C. Johansson, A. Yndestad, J. M. Enserink, A. H. Ree, P. Aukrust, and K. Tasken
The Epidermal Growth Factor-Like Growth Factor Amphiregulin Is Strongly Induced by the Adenosine 3',5'-Monophosphate Pathway in Various Cell Types
Endocrinology, November 1, 2004; 145(11): 5177 - 5184.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
K. Mahtouk, M. Jourdan, J. De Vos, C. Hertogh, G. Fiol, E. Jourdan, J.-F. Rossi, and B. Klein
An inhibitor of the EGF receptor family blocks myeloma cell growth factor activity of HB-EGF and potentiates dexamethasone or anti-IL-6 antibody-induced apoptosis
Blood, March 1, 2004; 103(5): 1829 - 1837.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. Pedron, C. Thibault, and P. J. Sansonetti
The Invasive Phenotype of Shigella flexneri Directs a Distinct Gene Expression Pattern in the Human Intestinal Epithelial Cell Line Caco-2
J. Biol. Chem., September 5, 2003; 278(36): 33878 - 33886.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Molecular and Cellular Proteomics 
 Journal of Lipid Research   ASBMB Today 
Copyright © 2002 by the American Society for Biochemistry and Molecular Biology.