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J. Biol. Chem., Vol. 277, Issue 52, 50941-50947, December 27, 2002
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From the Department of Pathology, Washington University School of
Medicine, St. Louis, Missouri 63110
The cellular adhesion molecule tenascin-R is a
multifunctional extracellular matrix component expressed exclusively in
the central nervous system. The expression of tenascin-R by
oligodendrocytes and small interneurons in the hippocampus and
cerebellum is highly regulated during development of these regions.
This complex glycoprotein displays both adhesive and anti-adhesive
properties that contribute to the formation and maintenance of
synapses. We have determined that tenascin-R associated with Purkinje
cell bodies and their dendrites in the molecular layer of the
cerebellum bears N-linked oligosaccharides terminating with
1,4-linked GalNAc-4-SO4, whereas tenascin-R in other
regions of the cerebellum does not bear this modification. Expression
of this unique sulfated carbohydrate structure is also temporally
regulated, increasing throughout cerebellar development. The most
dramatic increase in GalNAc-4-SO4 occurs between postnatal
days 14 and 21, corresponding to a period of Purkinje cell dendrite
extension and synaptogenesis. The spatially and temporally regulated
addition of this unique sulfated carbohydrate to tenascin-R may serve
to modulate its adhesive/anti-adhesive or other biological properties
in vivo.
To whom correspondence should be addressed. Tel.: 314-362-8730;
Fax: 314-362-8888; E-mail: Baenziger@pathology.wustl.edu.
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