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J. Biol. Chem., Vol. 277, Issue 7, 4853-4858, February 15, 2002

This Article Full Text Full Text (PDF) All Versions of this Article: 277/7/4853    most recent M108308200v1 Submit a Letter to Editor Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Mach, C. M. Articles by Kunkel, G. R. Search for Related Content PubMed PubMed Citation Articles by Mach, C. M. Articles by Kunkel, G. R. Social Bookmarking                      What's this?

The Small RNA Gene Activator Protein, SphI Postoctamer Homology-binding Factor/Selenocysteine tRNA Gene Transcription Activating Factor, Stimulates Transcription of the Human Interferon Regulatory Factor-3 Gene^*

Claire M. Mach, Brian W. Hargrove, and Gary R. Kunkel

From the Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas 77843-2128

Many small nuclear RNA gene promoters are activated by SphI postoctamer homology (SPH)-binding factor/selenocysteine tRNA gene transcription activating factor (SBF/Staf). Whereas this transcription factor was initially identified by its ability to bind to SPH elements in such promoters, it was more recently shown to have the capacity to activate transcription of a synthetic mRNA gene promoter through a distinct activation domain. Here, we show that the human interferon regulatory factor-3 (IRF-3) gene promoter contains a functional SPH element that is bound by SBF/Staf in vitro and in transfected cells.

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