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Originally published In Press as doi:10.1074/jbc.M108308200 on November 27, 2001

J. Biol. Chem., Vol. 277, Issue 7, 4853-4858, February 15, 2002
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The Small RNA Gene Activator Protein, SphI Postoctamer Homology-binding Factor/Selenocysteine tRNA Gene Transcription Activating Factor, Stimulates Transcription of the Human Interferon Regulatory Factor-3 Gene*

Claire M. Mach, Brian W. Hargrove, and Gary R. KunkelDagger

From the Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas 77843-2128

Many small nuclear RNA gene promoters are activated by SphI postoctamer homology (SPH)-binding factor/selenocysteine tRNA gene transcription activating factor (SBF/Staf). Whereas this transcription factor was initially identified by its ability to bind to SPH elements in such promoters, it was more recently shown to have the capacity to activate transcription of a synthetic mRNA gene promoter through a distinct activation domain. Here, we show that the human interferon regulatory factor-3 (IRF-3) gene promoter contains a functional SPH element that is bound by SBF/Staf in vitro and in transfected cells.

* This work was supported by National Science Foundation Grant MCB-9808214.The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

Dagger To whom correspondence should be addressed: Dept. of Biochemistry and Biophysics, Texas A&M University, 2128 TAMU, College Station, TX 77843-2128.

Copyright © 2002 by The American Society for Biochemistry and Molecular Biology, Inc.


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