JBC PeproTech; Our Business is Cytokines!

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Originally published In Press as doi:10.1074/jbc.M107627200 on December 5, 2001

J. Biol. Chem., Vol. 277, Issue 9, 6888-6897, March 1, 2002
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
277/9/6888    most recent
M107627200v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sajithlal, G.
Right arrow Articles by Münch, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sajithlal, G.
Right arrow Articles by Münch, G.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Receptor for Advanced Glycation End Products Plays a More Important Role in Cellular Survival than in Neurite Outgrowth during Retinoic Acid-induced Differentiation of Neuroblastoma Cells*

Gangadharan SajithlalDagger , Henri Huttunen§, Heikki Rauvala§, and Gerald MünchDagger

From the Dagger  Department of Neuroimmunological Cell Biology, Interdisziplinäres Zentrum für Klinische Forschung, University of Leipzig, Leipzig 04103, Germany and the § Programme of Molecular Neurobiology, Institute of Biotechnology, and the Department of Biosciences, University of Helsinki, Helsinki FIN-00014, Finland

The receptor for advanced glycation end products (RAGE), a member of the immunoglobulin superfamily, is known to interact with amphoterin. This interaction has been proposed to play a role in neurite outgrowth and process elongation during neurodifferentiation. However, there is as yet no direct evidence of the relevance of this pathway to neurodifferentiation under physiological conditions. In this study we have investigated a possible role of RAGE and amphoterin in the retinoic acid-induced differentiation of neuroblastoma cells. The functional inactivation of RAGE by dominant negative and antisense strategies showed that RAGE is not required for process outgrowth or differentiation, although overexpression of RAGE accelerates the elongation of neuritic processes. Using the antisense strategy, amphoterin was shown to be essential for process outgrowth and differentiation, suggesting that amphoterin may interact with other molecules to exert its effect in this context. Interestingly, the survival of the neuroblastoma cells treated with retinoic acid was partly dependent on the expression of RAGE, and inhibition of RAGE function partially blocked the increase in anti-apoptotic protein Bcl-2 following retinoic acid treatment. Based on these results we propose that a combination therapy using RAGE blockers and retinoic acid may prove as a useful approach for chemotherapy for the treatment of neuroblastoma.

* This work was supported by the Bundesministerium für Bildung, Forschung und Technologie, Interdisziplinäres Zentrum für Klinische Forschung (IZKF), at the University of Leipzig (01KS9504, Project N1) and by the Alexander von Humboldt Foundation (to G. S.).The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

To whom correspondence should be addressed: Neuroimmunologische Zellbiologie, IZKF, Leipzig Johannisallee 30a, Leipzig 04103, Germany. Tel.: 49-341-97-15945; Fax: 49-341-97-15949; E-mail: mueg@medizin.uni-leipzig.de.

Copyright © 2002 by The American Society for Biochemistry and Molecular Biology, Inc.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J. Neurosci.Home page
E. Sturchler, A. Galichet, M. Weibel, E. Leclerc, and C. W. Heizmann
Site-Specific Blockade of RAGE-Vd Prevents Amyloid-{beta} Oligomer Neurotoxicity
J. Neurosci., May 14, 2008; 28(20): 5149 - 5158.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Surg. Oncol.Home page
K. Hiwatashi, S. Ueno, K. Abeyama, F. Kubo, M. Sakoda, I. Maruyama, M. Hamanoue, S. Natsugoe, and T. Aikou
A Novel Function of the Receptor for Advanced Glycation End-Products (RAGE) in Association with Tumorigenesis and Tumor Differentiation of HCC
Ann. Surg. Oncol., March 1, 2008; 15(3): 923 - 933.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Pedrazzi, M. Patrone, M. Passalacqua, E. Ranzato, D. Colamassaro, B. Sparatore, S. Pontremoli, and E. Melloni
Selective Proinflammatory Activation of Astrocytes by High-Mobility Group Box 1 Protein Signaling
J. Immunol., December 15, 2007; 179(12): 8525 - 8532.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
E. Leclerc, G. Fritz, M. Weibel, C. W. Heizmann, and A. Galichet
S100B and S100A6 Differentially Modulate Cell Survival by Interacting with Distinct RAGE (Receptor for Advanced Glycation End Products) Immunoglobulin Domains
J. Biol. Chem., October 26, 2007; 282(43): 31317 - 31331.
[Abstract] [Full Text] [PDF]

Home page
 Sci Aging Knowl EnvironHome page
M. E. Obrenovich and V. M. Monnier
Apoptotic Killing of Fibroblasts by Matrix-Bound Advanced Glycation Endproducts
Sci. Aging Knowl. Environ., January 26, 2005; 2005(4): pe3 - pe3.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
J. S. Park, D. Svetkauskaite, Q. He, J.-Y. Kim, D. Strassheim, A. Ishizaka, and E. Abraham
Involvement of Toll-like Receptors 2 and 4 in Cellular Activation by High Mobility Group Box 1 Protein
J. Biol. Chem., February 27, 2004; 279(9): 7370 - 7377.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. A. Marques, U. Keil, A. Bonert, B. Steiner, C. Haass, W. E. Muller, and A. Eckert
Neurotoxic Mechanisms Caused by the Alzheimer's Disease-linked Swedish Amyloid Precursor Protein Mutation: OXIDATIVE STRESS, CASPASES, AND THE JNK PATHWAY
J. Biol. Chem., July 18, 2003; 278(30): 28294 - 28302.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. J. Huttunen, J. Kuja-Panula, and H. Rauvala
Receptor for Advanced Glycation End Products (RAGE) Signaling Induces CREB-dependent Chromogranin Expression during Neuronal Differentiation
J. Biol. Chem., October 4, 2002; 277(41): 38635 - 38646.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. N. Dahlgren, A. M. Manelli, W. B. Stine Jr., L. K. Baker, G. A. Krafft, and M. J. LaDu
Oligomeric and Fibrillar Species of Amyloid-beta Peptides Differentially Affect Neuronal Viability
J. Biol. Chem., August 23, 2002; 277(35): 32046 - 32053.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Molecular and Cellular Proteomics 
 Journal of Lipid Research   ASBMB Today 
Copyright © 2002 by the American Society for Biochemistry and Molecular Biology.