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J. Biol. Chem., Vol. 277, Issue 9, 7029-7036, March 1, 2002
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From the The Sp1/KLF family of factors regulates
diverse cellular processes, including growth and development. Fetal
Krüppel-like factor (FKLF2) is a new member of this
family. In this study, we characterized the coactivators involved in
FKLF2 transcriptional activation. Our results show that both CBP/p300
and p300/CBP-associated factor (PCAF) enhance FKLF2
transcriptional activity. We demonstrate that the acetyltransferase
activity of PCAF but not that of CBP/p300 is required for stimulating
FKLF2 transcription activity. We further show that p300 and PCAF act
cooperatively in stimulating FKLF2 transcriptional activation. FKLF2
interacts with both CBP and PCAF through specific domains, and CBP and
PCAF acetylate FKLF2. Both CBP/p300 and PCAF stimulate FKLF2 DNA
binding activity. The integrity of the acetyltransferase domain of PCAF
but not that of CBP/p300 is required for stimulating FKLF2 DNA binding
activity. These results demonstrate that CBP/p300 and PCAF stimulate
FKLF2 transcriptional activity at least by enhancing its DNA binding. The acetyltransferase activities of CBP/p300 and PCAF play a distinct role in stimulating FKLF2 transcription and DNA binding.
Division of Medical Genetics,
Department of Medicine, University of Washington, Seattle, Washington
98195 and the § First Department of Internal Medicine,
Nagoya University, Nagoya 461-8673, Japan
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