Advertisement
JBC

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Originally published In Press as doi:10.1074/jbc.M213244200 on January 10, 2003

J. Biol. Chem., Vol. 278, Issue 11, 9585-9591, March 14, 2003
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
278/11/9585    most recent
M213244200v1
Right arrow Submit a Letter to Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Li, Y.
Right arrow Articles by Tennekoon, G. I.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Li, Y.
Right arrow Articles by Tennekoon, G. I.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Lysophosphatidic Acid Promotes Survival and Differentiation of Rat Schwann Cells*

Yiwen LiDagger , Marco I. Gonzalez§, Judy L. Meinkoth§, Jeffrey Field§, Marcelo G. Kazanietz§, and Gihan I. TennekoonDagger

From the Departments of Dagger  Neurology and Pediatrics and § Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104

Lysophosphatidic acid (LPA; 1-acyl-sn-glycerol-3-phosphate), an abundant constituent of serum, mediates multiple biological responses via G protein-coupled serpentine receptors. Schwann cells express the LPA receptors (Edg receptors), which, once activated, have the potential to signal through Galpha i to activate p21ras and phosphatidylinositol 3-kinase, through Galpha q to activate phospholipase C, or through Gq12/13 to activate the Rho pathway. We found that the addition of serum or LPA to serum-starved Schwann cells rapidly (10 min) induced the appearance of actin stress fibers via a Rho-mediated pathway. Furthermore, LPA was able to rescue Schwann cells from apoptosis in a Galpha i/phosphatidylinositol 3-kinase/MEK/MAPK-dependent manner. In addition, LPA increased the expression of myelin protein P0 in Schwann cells in a Galpha i-independent manner but dependent on protein kinase C. By means of pharmacological and overexpression approaches, we found that the novel isozyme protein kinase Cdelta was required for myelin P0 expression. Thus, the multiple effects of LPA in Schwann cells (actin reorganization, survival, and myelin gene expression) appear to be mediated through the different G protein-dependent pathways activated by the LPA receptor.

* This work was supported by National Institutes of Health Grants R01 NS21700 (to G. T.) and R01 CA89202 (to M. G. K.) and National Multiple Sclerosis Society Grant RG2780 (to G. T.).The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

To whom correspondence should be addressed: 514 Abramson Bldg., 3400 Civic Center Blvd., Philadelphia, PA 19104. Tel.: 215-590-5177; Fax: 215-590-5195; E-mail: tennekoon@email.chop.edu.

Copyright © 2003 by The American Society for Biochemistry and Molecular Biology, Inc.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Clin. Cancer Res.Home page
B. B. Friday and A. A. Adjei
Advances in Targeting the Ras/Raf/MEK/Erk Mitogen-Activated Protein Kinase Cascade with MEK Inhibitors for Cancer Therapy
Clin. Cancer Res., January 15, 2008; 14(2): 342 - 346.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
J. Chen, A. R. Baydoun, R. Xu, L. Deng, X. Liu, W. Zhu, L. Shi, X. Cong, S. Hu, and X. Chen
Lysophosphatidic Acid Protects Mesenchymal Stem Cells Against Hypoxia and Serum Deprivation-Induced Apoptosis
Stem Cells, January 1, 2008; 26(1): 135 - 145.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
W. M. Campana, X. Li, N. Dragojlovic, J. Janes, A. Gaultier, and S. L. Gonias
The Low-Density Lipoprotein Receptor-Related Protein Is a Pro-Survival Receptor in Schwann Cells: Possible Implications in Peripheral Nerve Injury
J. Neurosci., October 25, 2006; 26(43): 11197 - 11207.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
B. Lu, Y. J. Jiang, M. Q. Man, B. Brown, P. M. Elias, and K. R. Feingold
Expression and regulation of 1-acyl-sn-glycerol- 3-phosphate acyltransferases in the epidermis
J. Lipid Res., November 1, 2005; 46(11): 2448 - 2457.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C. Jaillard, S. Harrison, B. Stankoff, M. S. Aigrot, A. R. Calver, G. Duddy, F. S. Walsh, M. N. Pangalos, N. Arimura, K. Kaibuchi, et al.
Edg8/S1P5: An Oligodendroglial Receptor with Dual Function on Process Retraction and Cell Survival
J. Neurosci., February 9, 2005; 25(6): 1459 - 1469.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
I. Tegeder and G. Geisslinger
Opioids As Modulators of Cell Death and Survival--Unraveling Mechanisms and Revealing New Indications
Pharmacol. Rev., September 1, 2004; 56(3): 351 - 369.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Molecular and Cellular Proteomics 
 Journal of Lipid Research   ASBMB Today 
Copyright © 2003 by the American Society for Biochemistry and Molecular Biology.
Advertisement
spacer
Advertisement
Advertisement