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Originally published In Press as doi:10.1074/jbc.M211874200 on January 8, 2003

J. Biol. Chem., Vol. 278, Issue 13, 11393-11401, March 28, 2003
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Association of the Kinesin Motor KIF1A with the Multimodular Protein Liprin-alpha *

Hyewon ShinDagger , Michael Wyszynski§, Kyung-Hye HuhDagger , Juli G. Valtschanoff||, Jae-Ran LeeDagger , Jaewon KoDagger , Michel Streuli**Dagger Dagger , Richard J. Weinberg||, Morgan Sheng§§§, and Eunjoon KimDagger ¶¶

From the Dagger  Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea, the § Center for Learning and Memory, RIKEN-MIT Neuroscience Research Center and Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, the || Department of Cell Biology and Anatomy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, and the ** Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115

Liprin-alpha /SYD-2 is a multimodular scaffolding protein important for presynaptic differentiation and postsynaptic targeting of alpha -amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid glutamate receptors. However, the molecular mechanisms underlying these functions remain largely unknown. Here we report that liprin-alpha interacts with the neuron-specific kinesin motor KIF1A. KIF1A colocalizes with liprin-alpha in various subcellular regions of neurons. KIF1A coaccumulates with liprin-alpha in ligated sciatic nerves. KIF1A cofractionates and coimmunopreciptates with liprin-alpha and various liprin-alpha -associated membrane, signaling, and scaffolding proteins including alpha -amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid receptors, GRIP/ABP, RIM, GIT1, and beta PIX. These results suggest that liprin-alpha functions as a KIF1A receptor, linking KIF1A to various liprin-alpha -associated proteins for their transport in neurons.

* This work was supported by grants from the Korean Ministry of Science and Technology, the Korea Research Foundation, and the Korea Science and Engineering Foundation (to E. K.) and National Institutes of Health Grant NS-35527 (to R. J. W.).The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

Present address: Amgen Inc., Thousand Oaks, CA 91320.

Dagger Dagger Present address: ImmunoGen, Inc., 128 Sidney St., Cambridge, MA 02139.

§§ Associate investigator of the Howard Hughes Medical Institute.

¶¶ To whom correspondence should be addressed: Dept. of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea. Tel.: 42-869-2633; Fax: 42-869-2610; E-mail: kime@mail.kaist.ac.kr.

Copyright © 2003 by The American Society for Biochemistry and Molecular Biology, Inc.
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