| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J. Biol. Chem., Vol. 278, Issue 15, 12613-12617, April 11, 2003
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
§,,,,,,,,
,,§§¶¶
From the Advanced glycation end
products (AGEs) are nonenzymatically glycosylated proteins, which
accumulate in vascular tissues in aging and diabetes. Receptors for
AGEs include scavenger receptors, which recognize acetylated low
density lipoproteins (Ac-LDL) such as scavenger receptor class AI/AII
(SR-A), cell surface glycoprotein CD36, scavenger receptor class
B type I (SR-BI), and lectin-like oxidized low density lipoprotein
receptor-1. The broad ligand repertoire of these receptors as
well as the diversity of the receptors for AGEs have prompted us to
examine whether AGEs are also recognized by the novel scavenger
receptors, which we have recently isolated from a cDNA library
prepared from human umbilical vein endothelial cells, such as
the scavenger receptor expressed by
endothelial cells-I (SREC-I); the
fasciclin EGF-like, laminin-type EGF-like, and link domain-containing scavenger
receptor-1 (FEEL-1); and its paralogous protein, FEEL-2. At
4 °C, 125I-AGE-bovine serum albumin (BSA) exhibited high
affinity specific binding to Chinese hamster ovary (CHO) cells
overexpressing FEEL-1 (CHO-FEEL-1) and FEEL-2 (CHO-FEEL-2) with
Kd of 2.55 and 1.68 µg/ml, respectively, but not
to CHO cells expressing SREC (CHO-SREC) and parent CHO cells. At
37 °C, 125I-AGE-BSA was taken up and degraded by
CHO-FEEL-1 and CHO-FEEL-2 cells but not by CHO-SREC and parent CHO
cells. Thus, the ability to bind Ac-LDL is not necessarily a
prerequisite to bind AGEs. The 125I-AGE-BSA binding
to CHO-FEEL-1 and CHO-FEEL-2 cells was effectively inhibited by Ac-LDL
and polyanionic SR-A inhibitors such as fucoidan, polyinosinic acids,
and dextran sulfate but not by native LDL, oxidized LDL, or HDL.
FEEL-1, which is expressed by the liver and vascular tissues, may
recognize AGEs, thereby contributing to the development of diabetic
vascular complications and atherosclerosis.
Departments of Metabolic Diseases,
** Cardiovascular Medicine, and
Infectious Diseases, Faculty of Medicine,
University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655 Japan; the
¶ Laboratory of Cellular Biochemistry, The Institute of
Physical and Chemical Research (RIKEN), Wako-shi, Saitama, 351-0198 Japan; the Departments of Metabolism, Endocrinology, and
Atherosclerosis, Institute of Clinical Medicine, University of Tsukuba,
1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575 Japan; and the
§§ Department of Internal Medicine, Jichi
Medical School, 3311-1 Yakushiji, Minamikawachi-machi, Kawachi-gun,
Tochigi, 329-0498 Japan
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  E. N. Harris, J. A. Weigel, and P. H. Weigel The Human Hyaluronan Receptor for Endocytosis (HARE/Stabilin-2) Is a Systemic Clearance Receptor for Heparin J. Biol. Chem., June 20, 2008; 283(25): 17341 - 17350. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-Y. Park, K.-B. Kang, N. Thapa, S.-Y. Kim, S.-J. Lee, and I.-S. Kim Requirement of Adaptor Protein GULP during Stabilin-2-mediated Cell Corpse Engulfment J. Biol. Chem., April 18, 2008; 283(16): 10593 - 10600. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Narazaki, M. Segarra, and G. Tosato Sulfated polysaccharides identified as inducers of neuropilin-1 internalization and functional inhibition of VEGF165 and semaphorin3A Blood, April 15, 2008; 111(8): 4126 - 4136. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Johnson, R. Prevo, S. Clasper, and D. G. Jackson Inflammation-induced Uptake and Degradation of the Lymphatic Endothelial Hyaluronan Receptor LYVE-1 J. Biol. Chem., November 16, 2007; 282(46): 33671 - 33680. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.-Y. Jung, S.-Y. Park, and I.-S. Kim Stabilin-2 is involved in lymphocyte adhesion to the hepatic sinusoidal endothelium via the interaction with {alpha}M 2 integrin J. Leukoc. Biol., November 1, 2007; 82(5): 1156 - 1165. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. S. Wang, E. E. Schadt, H. Wang, X. Wang, L. Ingram-Drake, W. Shi, T. A. Drake, and A. J. Lusis Identification of Pathways for Atherosclerosis in Mice: Integration of Quantitative Trait Locus Analysis and Global Gene Expression Data Circ. Res., August 3, 2007; 101(3): e11 - e30. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. N. Harris, S. V. Kyosseva, J. A. Weigel, and P. H. Weigel Expression, Processing, and Glycosaminoglycan Binding Activity of the Recombinant Human 315-kDa Hyaluronic Acid Receptor for Endocytosis (HARE) J. Biol. Chem., February 2, 2007; 282(5): 2785 - 2797. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. R. Theriault, H. Adachi, and S. K. Calderwood Role of Scavenger Receptors in the Binding and Internalization of Heat Shock Protein 70 J. Immunol., December 15, 2006; 177(12): 8604 - 8611. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Goldin, J. A. Beckman, A. M. Schmidt, and M. A. Creager Advanced Glycation End Products: Sparking the Development of Diabetic Vascular Injury Circulation, August 8, 2006; 114(6): 597 - 605. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Sato, N. Shimogaito, X. Wu, S. Kikuchi, S.-i. Yamagishi, and M. Takeuchi Toxic Advanced Glycation End Products (TAGE) Theory in Alzheimer's Disease American Journal of Alzheimer's Disease and Other Dementias, May 1, 2006; 21(3): 197 - 208. [Abstract] [PDF]
|
|
|
|
 |
|
 N. Nakano, K. Fukuhara-Takaki, T. Jono, K. Nakajou, N. Eto, S. Horiuchi, M. Takeya, and R. Nagai Association of Advanced Glycation End Products with A549 Cells, a Human Pulmonary Epithelial Cell Line, Is Mediated by a Receptor Distinct from the Scavenger Receptor Family and RAGE. J. Biochem., May 1, 2006; 139(5): 821 - 829. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Bito, S. Hino, A. Baba, M. Tanaka, H. Watabe, and H. Kawabata Degradation of oxidative stress-induced denatured albumin in rat liver endothelial cells Am J Physiol Cell Physiol, September 1, 2005; 289(3): C531 - C542. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. HORIUCHI, Y. UNNO, H. USUI, K. SHIKATA, K. TAKAKI, W. KOITO, Y.-I. SAKAMOTO, R. NAGAI, K. MAKINO, A. SASAO, et al. Pathological Roles of Advanced Glycation End Product Receptors SR-A and CD36 Ann. N.Y. Acad. Sci., June 1, 2005; 1043(1): 671 - 675. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. R. Greaves and S. Gordon Thematic review series: The Immune System and Atherogenesis. Recent insights into the biology of macrophage scavenger receptors J. Lipid Res., January 1, 2005; 46(1): 11 - 20. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Salmi, K. Koskinen, T. Henttinen, K. Elima, and S. Jalkanen CLEVER-1 mediates lymphocyte transmigration through vascular and lymphatic endothelium Blood, December 15, 2004; 104(13): 3849 - 3857. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Prevo, S. Banerji, J. Ni, and D. G. Jackson Rapid Plasma Membrane-Endosomal Trafficking of the Lymph Node Sinus and High Endothelial Venule Scavenger Receptor/Homing Receptor Stabilin-1 (Feel-1/Clever-1) J. Biol. Chem., December 10, 2004; 279(50): 52580 - 52592. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Kzhyshkowska, A. Gratchev, J.-H. Martens, O. Pervushina, S. Mamidi, S. Johansson, K. Schledzewski, B. Hansen, X. He, J. Tang, et al. Stabilin-1 localizes to endosomes and the trans-Golgi network in human macrophages and interacts with GGA adaptors J. Leukoc. Biol., December 1, 2004; 76(6): 1151 - 1161. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Tamura, J.-i. Osuga, H. Adachi, R.-i. Tozawa, Y. Takanezawa, K. Ohashi, N. Yahagi, M. Sekiya, H. Okazaki, S. Tomita, et al. Scavenger Receptor Expressed by Endothelial Cells I (SREC-I) Mediates the Uptake of Acetylated Low Density Lipoproteins by Macrophages Stimulated with Lipopolysaccharide J. Biol. Chem., July 23, 2004; 279(30): 30938 - 30944. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
