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J. Biol. Chem., Vol. 278, Issue 15, 12618-12623, April 11, 2003

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The Amyloid Precursor-like Protein 2 and the Adenoviral E3/19K Protein Both Bind to a Conformational Site on H-2K^d and Regulate H-2K^d Expression^*

Chantey R. Morris, Jason L. Petersen, Shanna E. Vargas^§, Heth R. Turnquist^§, Mary M. McIlhaney, Sam D. Sanderson^¶, Joseph T. Bruder, Yik Y. L. Yu^**, Hans-Gerhard Burgert, and Joyce C. Solheim^§§§¶¶

From the  Eppley Institute for Research in Cancer and Allied Diseases, the Departments of ^§ Pathology and Microbiology and ^§§ Biochemistry and Molecular Biology, and the ^¶ School of Allied Health Professions, University of Nebraska Medical Center, Omaha, Nebraska 68198,  GenVec, Gaithersburg, Maryland 20878, ^** NCI, National Institutes of Health, Bethesda, Maryland 20892, and the  Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, United Kingdom

A protein of unknown physiological function, called amyloid precursor-like protein 2 (APLP2), forms an association with the murine class I molecule K^d that is up-regulated by the presence of the adenoviral protein E3/19K. We have extended these findings to show that APLP2 and E3/19K associate preferentially with folded K^d and not with the open form. APLP2 was detectable at the cell surface, but its surface expression was not up-regulated by the concurrent expression of K^d. Experimental down-regulation of APLP2 expression caused a consistent increase in the surface expression of K^d, indicating that APLP2 normally reduces K^d surface expression. These data suggest a role for APLP2 in controlling the maturation of major histocompatibility complex class I molecules.

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