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J. Biol. Chem., Vol. 278, Issue 15, 13003-13007, April 11, 2003
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From the Expression of CCR5, a major coreceptor for human
immunodeficiency virus type 1 (HIV-1), is regulated by a number of
transcription factors. Here we report that the YY1 transcription
factor down-regulates CCR5 promoter activity and that overexpression of
YY1 reduces cell surface CCR5 expression and infectibility by
R5-HIV-1. Because YY1 also down-regulates promoter activities of
CXCR4, another major coreceptor for HIV-1 and HIV-1 long terminal
repeat, this transcription factor may play a critical role in the
pathogenesis of HIV-1 disease.
YY1 Transcription Factor Down-regulates Expression of CCR5, a
Major Coreceptor for HIV-1*
and§¶
Division of Medical Virology, Department of
Molecular Microbiology and Immunology, Nagasaki University Graduate
School of Biomedical Sciences, Nagasaki 852-8523, Japan and the
§ Department of Pediatrics, Nagasaki University Hospital,
Nagasaki 852-8501, Japan
*
This work was supported in part by a grant from the Research
for the Future Program (JSPS-RFTF97L00705) of the Japan Society for the
Promotion of Science and a grant-in-aid for Scientific Research on
Priority Areas from the Ministry of Education, Science, Sports, and
Culture, Japan.The costs of publication of this
article were defrayed in part by the
payment of page charges. The article must therefore be hereby marked
"advertisement" in
accordance with 18 U.S.C. Section
1734 solely to indicate this fact.
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