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J. Biol. Chem., Vol. 278, Issue 16, 13875-13880, April 18, 2003

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Polysialic Acid in Human Milk
CD36 IS A NEW MEMBER OF MAMMALIAN POLYSIALIC ACID-CONTAINING GLYCOPROTEIN^*

Uichiro Yabe, Chihiro Sato, Tsukasa Matsuda, and Ken Kitajima^§¶

From the Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464-8601, Japan, the  Department of Animal Sciences, Division of Organogenesis, Nagoya University Bioscience Center, Nagoya 464-8601, Japan, and the ^§ Institute for Advanced Research, Nagoya University, Nagoya 464-8601, Japan

The neural cell adhesion molecule and the voltage-sensitive sodium channel -subunit are the only two molecules in mammals known to be modified by -2,8-linked polysialic acid (polySia). We found a new polySia-containing glycoprotein in human milk and identified it as CD36, a member of the B class of the scavenger receptor superfamily. The polySia-containing glycan chain(s) were removed by alkaline treatment but not by peptide:N-glycanase F digestion, indicating that milk CD36 contained polySia on O-linked glycan chain(s). Polysialylation of CD36 occurs not only in human milk but also in mouse milk. However, CD36 in human platelets is not polysialylated. PolySia CD36 is secreted in milk at any lactation stage and reaches peak level at 1 month after parturition. Thus, it is suggested that polySia of milk CD36 is significant for neonatal development in terms of protection and nutrition.

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