HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

J. Biol. Chem., Vol. 278, Issue 16, 14306-14312, April 18, 2003

This Article Full Text Full Text (PDF) All Versions of this Article: 278/16/14306    most recent M210502200v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by de Belle, I. Articles by Adamson, E. D. Search for Related Content PubMed PubMed Citation Articles by de Belle, I. Articles by Adamson, E. D. Social Bookmarking                      What's this?

In Vivo Cloning and Characterization of a New Growth Suppressor Protein TOE1 as a Direct Target Gene of Egr1^*

Ian de Belle^§, Jie-Xin Wu, Sabina Sperandio^¶, Dan Mercola^**, and Eileen D. Adamson

From the  Burnham Institute, La Jolla Cancer Research Center, La Jolla, California 92037, the ^¶ Buck Institute for Age Research, Novato, California 94945, the  Sidney Kimmel Cancer Center, San Diego, California 92121, and the ^** Cancer Center, University of California at San Diego, La Jolla, California 92093

Egr1, an immediate early transcription factor, responds to diverse stimuli and affects gene transcription to accomplish its biological effects. One important effect of Egr1 expression is to decrease the growth and tumorigenic potential of several tumor cell types. To identify important Egr1 target genes, we have adapted a methodology involving formaldehyde-induced protein-DNA cross-linking, chromatin immunoprecipitation, and multiplex PCR. Using this approach, we report the cloning of a new Egr1 target gene that is able to account, at least in part, for the growth inhibitory activity of Egr1. We have named this new protein TOE1 for target of Egr1.

Ian de Belle and Sabina Sperandio dedicate this manuscript to the memory of Ted and Marilyn Crain.

CiteULike

Complore

Connotea

Del.icio.us

Digg

Reddit

Technorati

This article has been cited by other articles:

				E. Wagner, S. L. Clement, and J. Lykke-Andersen An Unconventional Human Ccr4-Caf1 Deadenylase Complex in Nuclear Cajal Bodies Mol. Cell. Biol., March 1, 2007; 27(5): 1686 - 1695. [Abstract] [Full Text] [PDF]

				B. Ferraro, G. Bepler, S. Sharma, A. Cantor, and E. B. Haura EGR1 Predicts PTEN and Survival in Patients With Non-Small-Cell Lung Cancer J. Clin. Oncol., March 20, 2005; 23(9): 1921 - 1926. [Abstract] [Full Text] [PDF]

				C. L. WILL, C. SCHNEIDER, M. HOSSBACH, H. URLAUB, R. RAUHUT, S. ELBASHIR, T. TUSCHL, and R. LUHRMANN The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome RNA, June 1, 2004; 10(6): 929 - 941. [Abstract] [Full Text] [PDF]