Advertisement
JBC

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Originally published In Press as doi:10.1074/jbc.M211446200 on January 29, 2003

J. Biol. Chem., Vol. 278, Issue 16, 14480-14486, April 18, 2003
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
278/16/14480    most recent
M211446200v1
Right arrow Submit a Letter to Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gilberger, T.-W.
Right arrow Articles by Cowman, A. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gilberger, T.-W.
Right arrow Articles by Cowman, A. F.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

A Novel Erythrocyte Binding Antigen-175 Paralogue from Plasmodium falciparum Defines a New Trypsin-resistant Receptor on Human Erythrocytes*

Tim-Wolf GilbergerDagger , Jennifer K. Thompson, Tony Triglia, Robert T. Good, Manoj T. Duraisingh, and Alan F. Cowman§

From The Walter and Eliza Hall Institute of Medical Research, Melbourne 3050, Australia

The recognition and invasion of human erythrocytes by the most lethal malaria parasite Plasmodium falciparum is dependent on multiple ligand-receptor interactions. Members of the erythrocyte binding-like (ebl) family, including the erythrocyte binding antigen-175 (EBA-175), are responsible for high affinity binding to glycoproteins on the surface of the erythrocyte. Here we describe a paralogue of EBA-175 and show that this protein (EBA-181/JESEBL) binds in a sialic acid-dependent manner to erythrocytes. EBA-181 is expressed at the same time as EBA-175 and co-localizes with this protein in the microneme organelles of asexual stage parasites. The receptor binding specificity of EBA-181 to erythrocytes differs from other members of the ebl family and is trypsin-resistant and chymotrypsin-sensitive. Furthermore, using glycophorin B-deficient erythrocytes we show that binding of EBA-181 is not dependent on this sialoglycoprotein. The level of expression of EBA-181 differs among parasite lines, and the importance of this ligand for invasion appears to be strain-dependent as the EBA-181 gene can be disrupted in W2mef parasites, without affecting the invasion phenotype, but cannot be targeted in 3D7 parasites.

* This work was supported by the National Health and Medical Research Council of Australia.The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

Dagger Funded by a Deutsche Forschunggemeinschaft Emmy Noether Fellowship.

§ A Howard Hughes International Scholar. To whom correspondence should be addressed: The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Melbourne, 3050, Australia. Tel.: 61-9345-2555; E-mail: cowman@wehi.edu.au.

Copyright © 2003 by The American Society for Biochemistry and Molecular Biology, Inc.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Infect. Immun.Home page
W.-H. Tham, D. W. Wilson, L. Reiling, L. Chen, J. G. Beeson, and A. F. Cowman
Antibodies to Reticulocyte Binding Protein-Like Homologue 4 Inhibit Invasion of Plasmodium falciparum into Human Erythrocytes
Infect. Immun., June 1, 2009; 77(6): 2427 - 2435.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
A. G. Maier, J. Baum, B. Smith, D. J. Conway, and A. F. Cowman
Polymorphisms in Erythrocyte Binding Antigens 140 and 181 Affect Function and Binding but Not Receptor Specificity in Plasmodium falciparum
Infect. Immun., April 1, 2009; 77(4): 1689 - 1699.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
S. Haase, A. Cabrera, C. Langer, M. Treeck, N. Struck, S. Herrmann, P. W. Jansen, I. Bruchhaus, A. Bachmann, S. Dias, et al.
Characterization of a Conserved Rhoptry-Associated Leucine Zipper-Like Protein in the Malaria Parasite Plasmodium falciparum
Infect. Immun., March 1, 2008; 76(3): 879 - 887.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
C. V. Jennings, A. D. Ahouidi, M. Zilversmit, A. K. Bei, J. Rayner, O. Sarr, O. Ndir, D. F. Wirth, S. Mboup, and M. T. Duraisingh
Molecular Analysis of Erythrocyte Invasion in Plasmodium falciparum Isolates from Senegal
Infect. Immun., July 1, 2007; 75(7): 3531 - 3538.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
A.-M. Deans, S. Nery, D. J. Conway, O. Kai, K. Marsh, and J. A. Rowe
Invasion Pathways and Malaria Severity in Kenyan Plasmodium falciparum Clinical Isolates
Infect. Immun., June 1, 2007; 75(6): 3014 - 3020.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Microbiol. Rev.Home page
D. J. Conway
Molecular Epidemiology of Malaria
Clin. Microbiol. Rev., January 1, 2007; 20(1): 188 - 204.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Treeck, N. S. Struck, S. Haase, C. Langer, S. Herrmann, J. Healer, A. F. Cowman, and T. W. Gilberger
A Conserved Region in the EBL Proteins Is Implicated in Microneme Targeting of the Malaria Parasite Plasmodium falciparum
J. Biol. Chem., October 20, 2006; 281(42): 31995 - 32003.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
R. A. O'Donnell, F. Hackett, S. A. Howell, M. Treeck, N. Struck, Z. Krnajski, C. Withers-Martinez, T. W. Gilberger, and M. J. Blackman
Intramembrane proteolysis mediates shedding of a key adhesin during erythrocyte invasion by the malaria parasite
J. Cell Biol., September 25, 2006; 174(7): 1023 - 1033.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
P. R. Sanders, L. M. Kats, D. R. Drew, R. A. O'Donnell, M. O'Neill, A. G. Maier, R. L. Coppel, and B. S. Crabb
A Set of Glycosylphosphatidyl Inositol-Anchored Membrane Proteins of Plasmodium falciparum Is Refractory to Genetic Deletion
Infect. Immun., July 1, 2006; 74(7): 4330 - 4338.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
P. R. Sanders, P. R. Gilson, G. T. Cantin, D. C. Greenbaum, T. Nebl, D. J. Carucci, M. J. McConville, L. Schofield, A. N. Hodder, J. R. Yates III, et al.
Distinct Protein Classes Including Novel Merozoite Surface Antigens in Raft-like Membranes of Plasmodium falciparum
J. Biol. Chem., December 2, 2005; 280(48): 40169 - 40176.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. J. Martin, J. C. Rayner, P. Gagneux, J. W. Barnwell, and A. Varki
Evolution of human-chimpanzee differences in malaria susceptibility: Relationship to human genetic loss of N-glycolylneuraminic acid
PNAS, September 6, 2005; 102(36): 12819 - 12824.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
J. Stubbs, K. M. Simpson, T. Triglia, D. Plouffe, C. J. Tonkin, M. T. Duraisingh, A. G. Maier, E. A. Winzeler, and A. F. Cowman
Molecular Mechanism for Switching of P. falciparum Invasion Pathways into Human Erythrocytes
Science, August 26, 2005; 309(5739): 1384 - 1387.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
K. M. VanBuskirk, E. Sevova, and J. H. Adams
Conserved residues in the Plasmodium vivax Duffy-binding protein ligand domain are critical for erythrocyte receptor recognition
PNAS, November 2, 2004; 101(44): 15754 - 15759.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
A. Cortes, A. Benet, B. M. Cooke, J. W. Barnwell, and J. C. Reeder
Ability of Plasmodium falciparum to invade Southeast Asian ovalocytes varies between parasite lines
Blood, November 1, 2004; 104(9): 2961 - 2966.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
C.-A. Lobo, K. de Frazao, M. Rodriguez, M. Reid, M. Zalis, and S. Lustigman
Invasion Profiles of Brazilian Field Isolates of Plasmodium falciparum: Phenotypic and Genotypic Analyses
Infect. Immun., October 1, 2004; 72(10): 5886 - 5891.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
D. C. G. Mayer, J.-B. Mu, O. Kaneko, J. Duan, X.-z. Su, and L. H. Miller
Polymorphism in the Plasmodium falciparum erythrocyte-binding ligand JESEBL/EBA-181 alters its receptor specificity
PNAS, February 24, 2004; 101(8): 2518 - 2523.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
X. Li, H. Chen, T. H. Oo, T. M. Daly, L. W. Bergman, S.-C. Liu, A. H. Chishti, and S. S. Oh
A Co-ligand Complex Anchors Plasmodium falciparum Merozoites to the Erythrocyte Invasion Receptor Band 3
J. Biol. Chem., February 13, 2004; 279(7): 5765 - 5771.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
D. Gaur, J. R. Storry, M. E. Reid, J. W. Barnwell, and L. H. Miller
Plasmodium falciparum Is Able To Invade Erythrocytes through a Trypsin-Resistant Pathway Independent of Glycophorin B
Infect. Immun., December 1, 2003; 71(12): 6742 - 6746.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
T.-W. Gilberger, J. K. Thompson, M. B. Reed, R. T. Good, and A. F. Cowman
The cytoplasmic domain of the Plasmodium falciparum ligand EBA-175 is essential for invasion but not protein trafficking
J. Cell Biol., July 21, 2003; 162(2): 317 - 327.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Molecular and Cellular Proteomics 
 Journal of Lipid Research   ASBMB Today 
Copyright © 2003 by the American Society for Biochemistry and Molecular Biology.
Advertisement
spacer
Advertisement
Advertisement