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J. Biol. Chem., Vol. 278, Issue 17, 14677-14687, April 25, 2003
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From the Center for Experimental Therapeutics and Reperfusion
Injury, Department of Anesthesiology, Perioperative and Pain Medicine,
Brigham and Women's Hospital and Harvard Medical School, Boston,
Massachusetts 02115
Docosahexaenoic acid (DHA, C22:6) is highly
enriched in brain, synapses, and retina and is a major
Novel Docosatrienes and 17S-Resolvins Generated from
Docosahexaenoic Acid in Murine Brain, Human Blood, and Glial
Cells
AUTACOIDS IN ANTI-INFLAMMATION*
,,
-3 fatty
acid. Deficiencies in this essential fatty acid are reportedly
associated with neuronal function, cancer, and inflammation. Here,
using new lipidomic analyses employing high performance liquid
chromatography coupled with a photodiode-array detector and a tandem
mass spectrometer, a novel series of endogenous mediators was
identified in blood, leukocytes, brain, and glial cells as
17S-hydroxy-containing docosanoids denoted as docosatrienes
(the main bioactive member of the series was
10,17S-docosatriene) and 17S series resolvins.
These novel mediators were biosynthesized via epoxide-containing
intermediates and proved potent (pico- to nanomolar range) regulators
of both leukocytes reducing infiltration in vivo and glial
cells blocking their cytokine production. These results indicate that
DHA is the precursor to potent protective mediators generated via
enzymatic oxygenations to novel docosatrienes and 17S
series resolvins that each regulate events of interest in inflammation
and resolution.
*
This work was supported in part by National Institute of
Health Grants GM38765 and P01-DE13499 (to C. N. S.) and DK60583 (to K. G.).The costs of publication of this
article were defrayed in part by the
payment of page charges. The article
must therefore be hereby marked
"advertisement" in
accordance with 18 U.S.C. Section
1734 solely to indicate this fact.
Both authors contributed equally to this work.
§
To whom correspondence should be addressed: Center for Experimental
Therapeutics and Reperfusion Injury, Thorn Medical Research Bldg., 7th
Floor, Brigham and Women's Hospital, Boston, MA 02115. Tel.:
617-732-8822; Fax: 617-582-6141; E-mail:
cnserhan@zeus.bwh.harvard.edu.
Copyright © 2003 by The American Society for Biochemistry and Molecular Biology, Inc.
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