JBC Avanti Polar Lipids

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Originally published In Press as doi:10.1074/jbc.M208419200 on October 23, 2002

J. Biol. Chem., Vol. 278, Issue 2, 1248-1258, January 10, 2003
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
278/2/1248    most recent
M208419200v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Zhang, X.
Right arrow Articles by Lee, P. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Zhang, X.
Right arrow Articles by Lee, P. J.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Carbon Monoxide Inhibition of Apoptosis during Ischemia-Reperfusion Lung Injury Is Dependent on the p38 Mitogen-activated Protein Kinase Pathway and Involves Caspase 3*

Xuchen ZhangDagger , Peiying ShanDagger , Leo E. Otterbein§, Jawed Alam||**, Richard A. FlavellDagger Dagger ***, Roger J. Davis§§, Augustine M. K. Choi§¶¶, and Patty J. LeeDagger ||||

From the Dagger  Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, § Division of Pulmonary, Allergy, and Critical Care, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, || Department of Molecular Genetics, Alton Ochsner Medical Foundation, New Orleans, Louisiana 70121, Dagger Dagger  Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, and §§ Program in Molecular Medicine, Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605

Carbon monoxide (CO), a reaction product of the cytoprotective gene heme oxygenase, has been shown to be protective against organ injury in a variety of models. One potential mechanism whereby CO affords cytoprotection is through its anti-apoptotic properties. Our studies show that low level, exogenous CO attenuates anoxia-reoxygenation (A-R)-induced lung endothelial cell apoptosis. Exposure of primary rat pulmonary artery endothelial cells to minimal levels of CO inhibits apoptosis and enhances phospho-p38 mitogen-activated protein kinase (MAPK) activation in A-R. Transfection of p38alpha dominant negative mutant or inhibition of p38 MAPK activity with SB203580 ablates the anti-apoptotic effects of CO in A-R. CO, through p38 MAPK, indirectly modulates caspase 3. Furthermore, we correlate our in vitro apoptosis model with an in vivo model of A-R by showing that CO can attenuate I-R injury of the lung. Taken together, our data are the first to demonstrate in models of A-R that the anti-apoptotic effects of CO are via modulation of p38 MAPK and caspase 3.

* The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

Supported by American Heart Association Grant 0160332U and by a Pfizer Atorvastatin Research Award.

** Supported by National Institutes of Health (NIH) Grant DK-43135.

*** An investigator of the Howard Hughes Medical Institute.

¶¶ Supported in part by NIH Grants HL-55330, AI-42365, and HL-60234 and by an American Heart Association Established Investigator Award (EIA).

|||| Supported by NIH Grant HL-04034 and by the American Lung Association of Connecticut. To whom correspondence should be addressed: Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, 333 Cedar St., LCI 105, New Haven, CT 06520. Tel.: 203-785-5877; Fax: 203-785-3826; E-mail: patty.lee@yale.edu.

Copyright © 2003 by The American Society for Biochemistry and Molecular Biology, Inc.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 IOVSHome page
M.-H. Sun, J.-H. S. Pang, S.-L. Chen, P.-C. Kuo, K.-J. Chen, L.-Y. Kao, J.-Y. Wu, K.-K. Lin, and Y.-P. Tsao
Photoreceptor Protection against Light Damage by AAV-Mediated Overexpression of Heme Oxygenase-1
Invest. Ophthalmol. Vis. Sci., December 1, 2007; 48(12): 5699 - 5707.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. N. Saha, M. Jana, and K. Pahan
MAPK p38 Regulates Transcriptional Activity of NF-{kappa}B in Primary Human Astrocytes via Acetylation of p65
J. Immunol., November 15, 2007; 179(10): 7101 - 7109.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
A. Zimmermann, C. W. Leffler, D. Tcheranova, A. L. Fedinec, and H. Parfenova
Cerebroprotective effects of the CO-releasing molecule CORM-A1 against seizure-induced neonatal vascular injury
Am J Physiol Heart Circ Physiol, October 1, 2007; 293(4): H2501 - H2507.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
D.-L. Dong, Y. Zhang, D.-H. Lin, J. Chen, S. Patschan, M. S. Goligorsky, A. Nasjletti, B.-F. Yang, and W.-H. Wang
Carbon Monoxide Stimulates the Ca2+ Activated Big Conductance K Channels in Cultured Human Endothelial Cells
Hypertension, October 1, 2007; 50(4): 643 - 651.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
X. Wang, Y. Wang, H. P. Kim, K. Nakahira, S. W. Ryter, and A. M. K. Choi
Carbon Monoxide Protects against Hyperoxia-induced Endothelial Cell Apoptosis by Inhibiting Reactive Oxygen Species Formation
J. Biol. Chem., January 19, 2007; 282(3): 1718 - 1726.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
H. B. Suliman, M. S. Carraway, L. G. Tatro, and C. A. Piantadosi
A new activating role for CO in cardiac mitochondrial biogenesis
J. Cell Sci., January 15, 2007; 120(2): 299 - 308.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Aburaya, K.-I. Tanaka, T. Hoshino, S. Tsutsumi, K. Suzuki, M. Makise, R. Akagi, and T. Mizushima
Heme Oxygenase-1 Protects Gastric Mucosal Cells against Non-steroidal Anti-inflammatory Drugs
J. Biol. Chem., November 3, 2006; 281(44): 33422 - 33432.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S.-i. Tsuchihashi, M. Livhits, Y. Zhai, R. W. Busuttil, J. A. Araujo, and J. W. Kupiec-Weglinski
Basal Rather Than Induced Heme Oxygenase-1 Levels Are Crucial in the Antioxidant Cytoprotection
J. Immunol., October 1, 2006; 177(7): 4749 - 4757.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
X. Zhang, P. Shan, G. Jiang, S. S-M. Zhang, L. E. Otterbein, X.-Y. Fu, and P. J. Lee
Endothelial STAT3 is essential for the protective effects of HO-1 in oxidant-induced lung injury
FASEB J, October 1, 2006; 20(12): 2156 - 2158.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
G. Silva, A. Cunha, I. P. Gregoire, M. P. Seldon, and M. P. Soares
The Antiapoptotic Effect of Heme Oxygenase-1 in Endothelial Cells Involves the Degradation of p38{alpha} MAPK Isoform
J. Immunol., August 1, 2006; 177(3): 1894 - 1903.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
S. Chlopicki, R. Olszanecki, E. Marcinkiewicz, M. Lomnicka, and R. Motterlini
Carbon monoxide released by CORM-3 inhibits human platelets by a mechanism independent of soluble guanylate cyclase
Cardiovasc Res, July 15, 2006; 71(2): 393 - 401.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
H. Parfenova, S. Basuroy, S. Bhattacharya, D. Tcheranova, Y. Qu, R. F. Regan, and C. W. Leffler
Glutamate induces oxidative stress and apoptosis in cerebral vascular endothelial cells: contributions of HO-1 and HO-2 to cytoprotection
Am J Physiol Cell Physiol, May 1, 2006; 290(5): C1399 - C1410.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. J. Marinissen, T. Tanos, M. Bolos, M. R. de Sagarra, O. A. Coso, and A. Cuadrado
Inhibition of Heme Oxygenase-1 Interferes with the Transforming Activity of the Kaposi Sarcoma Herpesvirusencoded G Protein-coupled Receptor
J. Biol. Chem., April 21, 2006; 281(16): 11332 - 11346.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
S. W. Ryter, J. Alam, and A. M. K. Choi
Heme Oxygenase-1/Carbon Monoxide: From Basic Science to Therapeutic Applications
Physiol Rev, April 1, 2006; 86(2): 583 - 650.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. W. Leffler, H. Parfenova, J. H. Jaggar, and R. Wang
Carbon monoxide and hydrogen sulfide: gaseous messengers in cerebrovascular circulation
J Appl Physiol, March 1, 2006; 100(3): 1065 - 1076.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
K. A. Kirkby and C. A. Adin
Products of heme oxygenase and their potential therapeutic applications
Am J Physiol Renal Physiol, March 1, 2006; 290(3): F563 - F571.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
J. K. Sarady-Andrews, F. Liu, D. Gallo, A. Nakao, M. Overhaus, R. Ollinger, A. M. Choi, and L. E. Otterbein
Biliverdin administration protects against endotoxin-induced acute lung injury in rats
Am J Physiol Lung Cell Mol Physiol, December 1, 2005; 289(6): L1131 - L1137.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
Y. Jin and A. M. K. Choi
Cytoprotection of Heme Oxygenase-1/Carbon Monoxide in Lung Injury
Proceedings of the ATS, October 1, 2005; 2(3): 232 - 235.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
D. Morse and A. M. K. Choi
Heme Oxygenase-1: From Bench to Bedside
Am. J. Respir. Crit. Care Med., September 15, 2005; 172(6): 660 - 670.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. M.K. Choi and T. Dolinay

Am. J. Respir. Crit. Care Med., June 1, 2005; 171(11): 1318 - 1319.
[Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
T. Vera, J. R. Henegar, H. A. Drummond, J. M. Rimoldi, and D. E. Stec
Protective Effect of Carbon Monoxide-Releasing Compounds in Ischemia-Induced Acute Renal Failure
J. Am. Soc. Nephrol., April 1, 2005; 16(4): 950 - 958.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
X. Zhang, P. Shan, J. Alam, X.-Y. Fu, and P. J. Lee
Carbon Monoxide Differentially Modulates STAT1 and STAT3 and Inhibits Apoptosis via a Phosphatidylinositol 3-Kinase/Akt and p38 Kinase-dependent STAT3 Pathway during Anoxia-Reoxygenation Injury
J. Biol. Chem., March 11, 2005; 280(10): 8714 - 8721.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
D. Lang, S. Reuter, T. Buzescu, C. August, and S. Heidenreich
Heme-induced heme oxygenase-1 (HO-1) in human monocytes inhibits apoptosis despite caspase-3 up-regulation
Int. Immunol., February 1, 2005; 17(2): 155 - 165.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
Z. Zhou, R. Song, C. L. Fattman, S. Greenhill, S. Alber, T. D. Oury, A. M.K. Choi, and D. Morse
Carbon Monoxide Suppresses Bleomycin-Induced Lung Fibrosis
Am. J. Pathol., January 1, 2005; 166(1): 27 - 37.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
J. S. Neto, A. Nakao, K. Kimizuka, A. J. Romanosky, D. B. Stolz, T. Uchiyama, M. A. Nalesnik, L. E. Otterbein, and N. Murase
Protection of transplant-induced renal ischemia-reperfusion injury with carbon monoxide
Am J Physiol Renal Physiol, November 1, 2004; 287(5): F979 - F989.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. Song, Z. Zhou, P. K. M. Kim, R. A. Shapiro, F. Liu, C. Ferran, A. M. K. Choi, and L. E. Otterbein
Carbon Monoxide Promotes Fas/CD95-induced Apoptosis in Jurkat Cells
J. Biol. Chem., October 22, 2004; 279(43): 44327 - 44334.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
T. Dolinay, M. Szilasi, M. Liu, and A. M. K. Choi
Inhaled Carbon Monoxide Confers Antiinflammatory Effects against Ventilator-induced Lung Injury
Am. J. Respir. Crit. Care Med., September 15, 2004; 170(6): 613 - 620.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
Y. Guo, A. B. Stein, W.-J. Wu, W. Tan, X. Zhu, Q.-H. Li, B. Dawn, R. Motterlini, and R. Bolli
Administration of a CO-releasing molecule at the time of reperfusion reduces infarct size in vivo
Am J Physiol Heart Circ Physiol, May 1, 2004; 286(5): H1649 - H1653.
[Abstract] [Full Text] [PDF]

Home page
 Sci SignalHome page
S. W. Ryter, D. Morse, and A. M. K. Choi
Carbon Monoxide: To Boldly Go Where NO Has Gone Before
Sci. Signal., April 27, 2004; 2004(230): re6 - re6.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H.-O. Pae, G.-S. Oh, B.-M. Choi, S.-C. Chae, Y.-M. Kim, K.-R. Chung, and H.-T. Chung
Carbon Monoxide Produced by Heme Oxygenase-1 Suppresses T Cell Proliferation via Inhibition of IL-2 Production
J. Immunol., April 15, 2004; 172(8): 4744 - 4751.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
C. S. Powell, M. M. Wright, and R. M. Jackson
p38mapk and MEK1/2 inhibition contribute to cellular oxidant injury after hypoxia
Am J Physiol Lung Cell Mol Physiol, April 1, 2004; 286(4): L826 - L833.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
X. Zhang, P. Shan, D. Jiang, P. W. Noble, N. G. Abraham, A. Kappas, and P. J. Lee
Small Interfering RNA Targeting Heme Oxygenase-1 Enhances Ischemia-Reperfusion-induced Lung Apoptosis
J. Biol. Chem., March 12, 2004; 279(11): 10677 - 10684.
[Abstract] [Full Text] [PDF]

Home page
 Ann. N. Y. Acad. Sci.Home page
K. R. WAGNER and B. E. DWYER
Hematoma Removal, Heme, and Heme Oxygenase Following Hemorrhagic Stroke
Ann. N.Y. Acad. Sci., March 1, 2004; 1012(1): 237 - 251.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. Song, R. S. Mahidhara, Z. Zhou, R. A. Hoffman, D.-W. Seol, R. A. Flavell, T. R. Billiar, L. E. Otterbein, and A. M. K. Choi
Carbon Monoxide Inhibits T Lymphocyte Proliferation via Caspase-Dependent Pathway
J. Immunol., January 15, 2004; 172(2): 1220 - 1226.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
G. Kronke, V. N. Bochkov, J. Huber, F. Gruber, S. Bluml, A. Furnkranz, A. Kadl, B. R. Binder, and N. Leitinger
Oxidized Phospholipids Induce Expression of Human Heme Oxygenase-1 Involving Activation of cAMP-responsive Element-binding Protein
J. Biol. Chem., December 19, 2003; 278(51): 51006 - 51014.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
A. Nakao, K. Kimizuka, D. B. Stolz, J. S. Neto, T. Kaizu, A. M. K. Choi, T. Uchiyama, B. S. Zuckerbraun, M. A. Nalesnik, L. E. Otterbein, et al.
Carbon Monoxide Inhalation Protects Rat Intestinal Grafts from Ischemia/Reperfusion Injury
Am. J. Pathol., October 1, 2003; 163(4): 1587 - 1598.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
X. Zhang, P. Shan, J. Alam, R. J. Davis, R. A. Flavell, and P. J. Lee
Carbon Monoxide Modulates Fas/Fas Ligand, Caspases, and Bcl-2 Family Proteins via the p38{alpha} Mitogen-activated Protein Kinase Pathway during Ischemia-Reperfusion Lung Injury
J. Biol. Chem., June 6, 2003; 278(24): 22061 - 22070.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Molecular and Cellular Proteomics 
 Journal of Lipid Research   ASBMB Today 
Copyright © 2003 by the American Society for Biochemistry and Molecular Biology.