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J. Biol. Chem., Vol. 278, Issue 22, 19904-19908, May 30, 2003

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Telomerase Expression in Normal Human Fibroblasts Stabilizes DNA 5-Methylcytosine Transferase I^*

Juan I. Young  , John M. Sedivy ¶ and James R. Smith  || **

From the Roy M. and Phyllis Gough Huffington Center on Aging, ^¶Departments of Molecular Virology and Microbiology, Molecular and Cellular Biology, and Medicine, Baylor College of Medicine, Houston, Texas 77030 and ^||Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, Rhode Island 02912

The finite proliferative potential of normal human fibroblasts can be overcome, a process commonly called immortalization, by the introduction of the catalytic subunit of human telomerase. In contrast to malignant transformation, the pattern of gene expression remains largely unmodified in telomerase-induced immortalization. Here we show evidence that suggests that the maintenance of a "young" pattern of gene expression by telomerization is mediated, at least in part, by a novel function of human telomerase that involves regulation of DNA methyltransferase I gene expression.

Received for publication, February 18, 2003 , and in revised form, March 25, 2003.

^* This work was supported in part by NIA, National Institutes of Health Grant AG13663. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

^** Present address: Sam and Ann Barshop Center on Longevity and Aging, University of Texas Health Science Center, San Antonio, TX 78245.

Partially supported by a Francisco Macri postdoctoral fellowship. To whom correspondence should be addressed. Tel.: 713-798-6695; Fax: 713-798-8728; E-mail: jyoung{at}bcm.tmc.edu.

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