|
|
|
|||||||
|
|||||||||
J. Biol. Chem., Vol. 278, Issue 22, 20345-20357, May 30, 2003
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Genome-wide Analysis of the Response to Cell Wall Mutations in the Yeast Saccharomyces cerevisiae*
|| || 
From the
Centre de Bioingenierie Gilbert Durand, UMR-CNRS 5504 and INRA 792, France, ||Transcriptome-Biochips plateform, Genopole de Toulouse, 135 Avenue de Rangeuil, 31077 Toulouse, France, the ¶Division of Functional Genome Analysis, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 506, 69120 Heidelberg, Germany, and the **Departamento de Microbiología II, Facultad de Farmacia, Universidad Complutense de Madrid, 28040 Madrid, Spain
Perturbations of the yeast cell wall trigger a repair mechanism that reconfigures its molecular structure to preserve cell integrity. To investigate this mechanism, we compared the global gene expression in five mutant strains, each bearing a mutation (i.e. fks1, kre6, mnn9, gas1, and knr4 mutants) that affects in a different manner the cell wall construction. Altogether, 300 responsive genes were kept based on high stringency criteria during data processing. Functional classification of these differentially expressed genes showed a substantial subset of induced genes involved in cell wall construction and an enrichment of metabolic, energy generation, and cell defense categories, whereas families of genes belonging to transcription, protein synthesis, and cellular growth were underrepresented. Clustering methods isolated a single group of 
80 up-regulated genes that could be considered as the stereotypical transcriptional response of the cell wall compensatory mechanism. The in silico analysis of the DNA upstream region of these co-regulated genes revealed pairwise combinations of DNA-binding sites for transcriptional factors implicated in stress and heat shock responses (Msn2/4p and Hsf1p) with Rlm1p and Swi4p, two PKC1-regulated transcription factors involved in the activation genes related to cell wall biogenesis and G1/S transition. Moreover, this computational analysis also uncovered the 6-bp 5'-AGCCTC-3' CDRE (calcineurin-dependent response element) motif in 40% of the co-regulated genes. This motif was recently shown to be the DNA binding site for Crz1p, the major effector of calcineurin-regulated gene expression in yeast. Taken altogether, the data presented here lead to the conclusion that the cell wall compensatory mechanism, as triggered by cell wall mutations, integrates three major regulatory systems: namely the PKC1-SLT2 mitogen-activated protein kinase-signaling module, the "global stress" response mediated by Msn2/4p, and the Ca2+/calcineurin-dependent pathway. The relative importance of these regulatory systems in the cell wall compensatory mechanism is discussed.
Received for publication, November 14, 2002 , and in revised form, January 30, 2003.
* This work was supported in part by European Union Grant QLK3-2000-01537 (to J. F., J. A., and J. H.) and by Fonds de Recherche Hoechst Marion Roussel Grant FRHMR 2/9922 (to J. F.). The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
Recipient of a predoctoral fellowship from the French Ministry of Research and Technology Education.
To whom correspondence should be addressed. Tel.: 33-5-61-55-9492; Fax: 33-5-61-55-9400; E-mail: fran_jm{at}insa-tlse.fr.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  M. R. Koch and L. Pillus From the Cover: The glucanosyltransferase Gas1 functions in transcriptional silencing PNAS, July 7, 2009; 106(27): 11224 - 11229. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Garcia, J. M. Rodriguez-Pena, C. Bermejo, C. Nombela, and J. Arroyo The High Osmotic Response and Cell Wall Integrity Pathways Cooperate to Regulate Transcriptional Responses to Zymolyase-induced Cell Wall Stress in Saccharomyces cerevisiae J. Biol. Chem., April 17, 2009; 284(16): 10901 - 10911. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Pinchai, B. Z. Perfect, P. R. Juvvadi, J. R. Fortwendel, R. A. Cramer Jr., Y. G. Asfaw, J. Heitman, J. R. Perfect, and W. J. Steinbach Aspergillus fumigatus Calcipressin CbpA Is Involved in Hyphal Growth and Calcium Homeostasis Eukaryot. Cell, April 1, 2009; 8(4): 511 - 519. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Cabib, V. Farkas, O. Kosik, N. Blanco, J. Arroyo, and P. McPhie Assembly of the Yeast Cell Wall: Crh1p AND Crh2p ACT AS TRANSGLYCOSYLASES IN VIVO AND IN VITRO J. Biol. Chem., October 31, 2008; 283(44): 29859 - 29872. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Del Vescovo, V. Casagrande, M. M. Bianchi, E. Piccinni, L. Frontali, C. Militti, V. Fardeau, F. Devaux, C. D. Sanza, C. Presutti, et al. Role of Hog1 and Yaf9 in the transcriptional response of Saccharomyces cerevisiae to cesium chloride Physiol Genomics, October 8, 2008; 33(1): 110 - 120. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. A. Abbott, E. Suir, A. J. A. van Maris, and J. T. Pronk Physiological and Transcriptional Responses to High Concentrations of Lactic Acid in Anaerobic Chemostat Cultures of Saccharomyces cerevisiae Appl. Envir. Microbiol., September 15, 2008; 74(18): 5759 - 5768. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Popolo, E. Ragni, C. Carotti, O. Palomares, R. Aardema, J. W. Back, H. L. Dekker, L. J. de Koning, L. de Jong, and C. G. de Koster Disulfide Bond Structure and Domain Organization of Yeast {beta}(1,3)-Glucanosyltransferases Involved in Cell Wall Biogenesis J. Biol. Chem., July 4, 2008; 283(27): 18553 - 18565. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. J. Luallen, J. Lin, H. Fu, K. K. Cai, C. Agrawal, I. Mboudjeka, F.-H. Lee, D. Montefiori, D. F. Smith, R. W. Doms, et al. An Engineered Saccharomyces cerevisiae Strain Binds the Broadly Neutralizing Human Immunodeficiency Virus Type 1 Antibody 2G12 and Elicits Mannose-Specific gp120-Binding Antibodies J. Virol., July 1, 2008; 82(13): 6447 - 6457. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Loukin, X. Zhou, C. Kung, and Y. Saimi A genome-wide survey suggests an osmoprotective role for vacuolar Ca2+ release in cell wall-compromised yeast FASEB J, July 1, 2008; 22(7): 2405 - 2415. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Zhang, Y. Liang, X. Zhang, Y. Xu, H. Dai, and W. Xiao Deletion of Yeast CWP Genes Enhances Cell Permeability to Genotoxic Agents Toxicol. Sci., May 1, 2008; 103(1): 68 - 76. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Bermejo, E. Rodriguez, R. Garcia, J. M. Rodriguez-Pena, M. L. Rodriguez de la Concepcion, C. Rivas, P. Arias, C. Nombela, F. Posas, and J. Arroyo The Sequential Activation of the Yeast HOG and SLT2 Pathways Is Required for Cell Survival to Cell Wall Stress Mol. Biol. Cell, March 1, 2008; 19(3): 1113 - 1124. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. A. Damveld, A. Franken, M. Arentshorst, P. J. Punt, F. M. Klis, C. A. M. J. J. van den Hondel, and A. F. J. Ram A Novel Screening Method for Cell Wall Mutants in Aspergillus niger Identifies UDP-Galactopyranose Mutase as an Important Protein in Fungal Cell Wall Biosynthesis Genetics, February 1, 2008; 178(2): 873 - 881. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. S. Narang, C. L. Malone, R. J. Deschenes, and J. S. Fassler Modulation of Yeast Sln1 Kinase Activity by the Ccw12 Cell Wall Protein J. Biol. Chem., January 25, 2008; 283(4): 1962 - 1973. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Meyer, R. A. Damveld, M. Arentshorst, U. Stahl, C. A. M. J. J. van den Hondel, and A. F. J. Ram Survival in the Presence of Antifungals: GENOME-WIDE EXPRESSION PROFILING OF ASPERGILLUS NIGER IN RESPONSE TO SUBLETHAL CONCENTRATIONS OF CASPOFUNGIN AND FENPROPIMORPH J. Biol. Chem., November 9, 2007; 282(45): 32935 - 32948. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Zhong, G. Li, J. Gvozdenovic-Jeremic, and M. L. Greenberg Up-regulation of the Cell Integrity Pathway in Saccharomyces cerevisiae Suppresses Temperature Sensitivity of the pgs1{Delta} Mutant J. Biol. Chem., June 1, 2007; 282(22): 15946 - 15953. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. W. Truman, S. H. Millson, J. M. Nuttall, M. Mollapour, C. Prodromou, and P. W. Piper In the Yeast Heat Shock Response, Hsf1-Directed Induction of Hsp90 Facilitates the Activation of the Slt2 (Mpk1) Mitogen-Activated Protein Kinase Required for Cell Integrity Eukaryot. Cell, April 1, 2007; 6(4): 744 - 752. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Ragni, A. Coluccio, E. Rolli, J. M. Rodriguez-Pena, G. Colasante, J. Arroyo, A. M. Neiman, and L. Popolo GAS2 and GAS4, a Pair of Developmentally Regulated Genes Required for Spore Wall Assembly in Saccharomyces cerevisiae Eukaryot. Cell, February 1, 2007; 6(2): 302 - 316. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Serrano, H. Martin, A. Casamayor, and J. Arino Signaling Alkaline pH Stress in the Yeast Saccharomyces cerevisiae through the Wsc1 Cell Surface Sensor and the Slt2 MAPK Pathway J. Biol. Chem., December 29, 2006; 281(52): 39785 - 39795. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Platara, A. Ruiz, R. Serrano, A. Palomino, F. Moreno, and J. Arino The Transcriptional Response of the Yeast Na+-ATPase ENA1 Gene to Alkaline Stress Involves Three Main Signaling Pathways J. Biol. Chem., December 1, 2006; 281(48): 36632 - 36642. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Varelas, D. Stuart, M. J. Ellison, and C. Ptak The Cdc34/SCF Ubiquitination Complex Mediates Saccharomyces cerevisiae Cell Wall Integrity Genetics, December 1, 2006; 174(4): 1825 - 1839. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Gonzalez, A. Ruiz, R. Serrano, J. Arino, and A. Casamayor Transcriptional Profiling of the Protein Phosphatase 2C Family in Yeast Provides Insights into the Unique Functional Roles of Ptc1 J. Biol. Chem., November 17, 2006; 281(46): 35057 - 35069. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Simoes, N. P. Mira, A. R. Fernandes, and I. Sa-Correia The SPI1 Gene, Encoding a Glycosylphosphatidylinositol-Anchored Cell Wall Protein, Plays a Prominent Role in the Development of Yeast Resistance to Lipophilic Weak-Acid Food Preservatives Appl. Envir. Microbiol., November 1, 2006; 72(11): 7168 - 7175. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Deng, R. Sugiura, M. Takeuchi, M. Suzuki, H. Ebina, T. Takami, A. Koike, S. Iba, and T. Kuno Real-Time Monitoring of Calcineurin Activity in Living Cells: Evidence for Two Distinct Ca2+-dependent Pathways in Fission Yeast Mol. Biol. Cell, November 1, 2006; 17(11): 4790 - 4800. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. L. Eastmond and H. C. M. Nelson Genome-wide Analysis Reveals New Roles for the Activation Domains of the Saccharomyces cerevisiae Heat Shock Transcription Factor (Hsf1) during the Transient Heat Shock Response J. Biol. Chem., October 27, 2006; 281(43): 32909 - 32921. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Lesage and H. Bussey Cell Wall Assembly in Saccharomyces cerevisiae Microbiol. Mol. Biol. Rev., June 1, 2006; 70(2): 317 - 343. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Castrejon, A. Gomez, M. Sanz, A. Duran, and C. Roncero The RIM101 Pathway Contributes to Yeast Cell Wall Assembly and Its Function Becomes Essential in the Absence of Mitogen-Activated Protein Kinase Slt2p Eukaryot. Cell, March 1, 2006; 5(3): 507 - 517. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Friesen, C. Humphries, Y. Ho, O. Schub, K. Colwill, and B. Andrews Characterization of the Yeast Amphiphysins Rvs161p and Rvs167p Reveals Roles for the Rvs Heterodimer In Vivo Mol. Biol. Cell, March 1, 2006; 17(3): 1306 - 1321. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Chasse, P. Flanary, S. C. Parnell, N. Hao, J. Y. Cha, D. P. Siderovski, and H. G. Dohlman Genome-Scale Analysis Reveals Sst2 as the Principal Regulator of Mating Pheromone Signaling in the Yeast Saccharomyces cerevisiae Eukaryot. Cell, February 1, 2006; 5(2): 330 - 346. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Singh, D. Kumar, N. Ramakrishnan, V. Singhal, J. Jervis, J. F. Garst, S. M. Slaughter, A. M. DeSantis, M. Potts, and R. F. Helm Transcriptional Response of Saccharomyces cerevisiae to Desiccation and Rehydration Appl. Envir. Microbiol., December 1, 2005; 71(12): 8752 - 8763. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. S. Abraham and A. K. Vershon N-Terminal Arm of Mcm1 Is Required for Transcription of a Subset of Genes Involved in Maintenance of the Cell Wall Eukaryot. Cell, November 1, 2005; 4(11): 1808 - 1819. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Sumita, T. Yoko-o, Y.-i. Shimma, and Y. Jigami Comparison of Cell Wall Localization among Pir Family Proteins and Functional Dissection of the Region Required for Cell Wall Binding and Bud Scar Recruitment of Pir1p Eukaryot. Cell, November 1, 2005; 4(11): 1872 - 1881. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Conesa, R. Ruotolo, P. Soularue, T. A. Simms, D. Donze, A. Sentenac, and G. Dieci Modulation of Yeast Genome Expression in Response to Defective RNA Polymerase III-Dependent Transcription Mol. Cell. Biol., October 1, 2005; 25(19): 8631 - 8642. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. Wong and F. P. Roth Transcriptional Compensation for Gene Loss Plays a Minor Role in Maintaining Genetic Robustness in Saccharomyces cerevisiae Genetics, October 1, 2005; 171(2): 829 - 833. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Rodriguez-Pena, R. M. Perez-Diaz, S. Alvarez, C. Bermejo, R. Garcia, C. Santiago, C. Nombela, and J. Arroyo The 'yeast cell wall chip' - a tool to analyse the regulation of cell wall biogenesis in Saccharomyces cerevisiae Microbiology, July 1, 2005; 151(7): 2241 - 2249. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. E. Levin Cell Wall Integrity Signaling in Saccharomyces cerevisiae Microbiol. Mol. Biol. Rev., June 1, 2005; 69(2): 262 - 291. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Y. Yin, P. W. J. de Groot, H. L. Dekker, L. de Jong, F. M. Klis, and C. G. de Koster Comprehensive Proteomic Analysis of Saccharomyces cerevisiae Cell Walls: IDENTIFICATION OF PROTEINS COVALENTLY ATTACHED VIA GLYCOSYLPHOSPHATIDYLINOSITOL REMNANTS OR MILD ALKALI-SENSITIVE LINKAGES J. Biol. Chem., May 27, 2005; 280(21): 20894 - 20901. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Zakrzewska, A. Boorsma, S. Brul, K. J. Hellingwerf, and F. M. Klis Transcriptional Response of Saccharomyces cerevisiae to the Plasma Membrane-Perturbing Compound Chitosan Eukaryot. Cell, April 1, 2005; 4(4): 703 - 715. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Vilella, E. Herrero, J. Torres, and M. A. de la Torre-Ruiz Pkc1 and the Upstream Elements of the Cell Integrity Pathway in Saccharomyces cerevisiae, Rom2 and Mtl1, Are Required for Cellular Responses to Oxidative Stress J. Biol. Chem., March 11, 2005; 280(10): 9149 - 9159. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Imai, Y. Noda, H. Adachi, and K. Yoda A Novel Endoplasmic Reticulum Membrane Protein Rcr1 Regulates Chitin Deposition in the Cell Wall of Saccharomyces cerevisiae J. Biol. Chem., March 4, 2005; 280(9): 8275 - 8284. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Zhong, J. Gvozdenovic-Jeremic, P. Webster, J. Zhou, and M. L. Greenberg Loss of Function of KRE5 Suppresses Temperature Sensitivity of Mutants Lacking Mitochondrial Anionic Lipids Mol. Biol. Cell, February 1, 2005; 16(2): 665 - 675. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Munro, S. Bates, E. T. Buurman, H. B. Hughes, D. M. MacCallum, G. Bertram, A. Atrih, M. A. J. Ferguson, J. M. Bain, A. Brand, et al. Mnt1p and Mnt2p of Candida albicans Are Partially Redundant {alpha}-1,2-Mannosyltransferases That Participate in O-Linked Mannosylation and Are Required for Adhesion and Virulence J. Biol. Chem., January 14, 2005; 280(2): 1051 - 1060. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. G. Perrone, C. M. Grant, and I. W. Dawes Genetic and Environmental Factors Influencing Glutathione Homeostasis in Saccharomyces cerevisiae Mol. Biol. Cell, January 1, 2005; 16(1): 218 - 230. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Pardo, L. Monteoliva, P. Vazquez, R. Martinez, G. Molero, C. Nombela, and C. Gil PST1 and ECM33 encode two yeast cell surface GPI proteins important for cell wall integrity Microbiology, December 1, 2004; 150(12): 4157 - 4170. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Bey, K. Stuber, K. Fellenberg, Z. Schwarz-Sommer, H. Sommer, H. Saedler, and S. Zachgo Characterization of Antirrhinum Petal Development and Identification of Target Genes of the Class B MADS Box Gene DEFICIENS PLANT CELL, December 1, 2004; 16(12): 3197 - 3215. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Mille, G. Janbon, F. Delplace, S. Ibata-Ombetta, C. Gaillardin, G. Strecker, T. Jouault, P.-A. Trinel, and D. Poulain Inactivation of CaMIT1 Inhibits Candida albicans Phospholipomannan {beta}-Mannosylation, Reduces Virulence, and Alters Cell Wall Protein {beta}-Mannosylation J. Biol. Chem., November 12, 2004; 279(46): 47952 - 47960. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Viladevall, R. Serrano, A. Ruiz, G. Domenech, J. Giraldo, A. Barcelo, and J. Arino Characterization of the Calcium-mediated Response to Alkaline Stress in Saccharomyces cerevisiae J. Biol. Chem., October 15, 2004; 279(42): 43614 - 43624. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Sestak, I. Hagen, W. Tanner, and S. Strahl Scw10p, a cell-wall glucanase/transglucosidase important for cell-wall stability in Saccharomyces cerevisiae Microbiology, October 1, 2004; 150(10): 3197 - 3208. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. F. J. Ram, M. Arentshorst, R. A. Damveld, P. A. vanKuyk, F. M. Klis, and C. A. M. J. J. van den Hondel The cell wall stress response in Aspergillus niger involves increased expression of the glutamine : fructose-6-phosphate amidotransferase-encoding gene (gfaA) and increased deposition of chitin in the cell wall Microbiology, October 1, 2004; 150(10): 3315 - 3326. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Wang, S. Vavassori, L. M. Schweizer, and M. Schweizer Impaired PRPP-synthesizing capacity compromises cell integrity signalling in Saccharomyces cerevisiae Microbiology, October 1, 2004; 150(10): 3327 - 3339. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Sussman, K. Huss, L.-C. Chio, S. Heidler, M. Shaw, D. Ma, G. Zhu, R. M. Campbell, T.-S. Park, P. Kulanthaivel, et al. Discovery of Cercosporamide, a Known Antifungal Natural Product, as a Selective Pkc1 Kinase Inhibitor through High-Throughput Screening Eukaryot. Cell, August 1, 2004; 3(4): 932 - 943. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. W. J. de Groot, A. D. de Boer, J. Cunningham, H. L. Dekker, L. de Jong, K. J. Hellingwerf, C. de Koster, and F. M. Klis Proteomic Analysis of Candida albicans Cell Walls Reveals Covalently Bound Carbohydrate-Active Enzymes and Adhesins Eukaryot. Cell, August 1, 2004; 3(4): 955 - 965. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Mizutani, A. Nojima, M. Yamamoto, K. Furukawa, T. Fujioka, Y. Yamagata, K. Abe, and T. Nakajima Disordered Cell Integrity Signaling Caused by Disruption of the kexB Gene in Aspergillus oryzae Eukaryot. Cell, August 1, 2004; 3(4): 1036 - 1048. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. N. Ledger, P. Pinton, D. Bourges, P. Roumi, H. Salmon, and I. P. Oswald Development of a Macroarray To Specifically Analyze Immunological Gene Expression in Swine Clin. Vaccine Immunol., July 1, 2004; 11(4): 691 - 698. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. Parveen, Md. K. Hasan, J. Takahashi, Y. Murata, E. Kitagawa, O. Kodama, and H. Iwahashi Response of Saccharomyces cerevisiae to a monoterpene: evaluation of antifungal potential by DNA microarray analysis J. Antimicrob. Chemother., July 1, 2004; 54(1): 46 - 55. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Lesage, A.-M. Sdicu, P. Menard, J. Shapiro, S. Hussein, and H. Bussey Analysis of {beta}-1,3-Glucan Assembly in Saccharomyces cerevisiae Using a Synthetic Interaction Network and Altered Sensitivity to Caspofungin Genetics, May 1, 2004; 167(1): 35 - 49. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Garcia, C. Bermejo, C. Grau, R. Perez, J. M. Rodriguez-Pena, J. Francois, C. Nombela, and J. Arroyo The Global Transcriptional Response to Transient Cell Wall Damage in Saccharomyces cerevisiae and Its Regulation by the Cell Integrity Signaling Pathway J. Biol. Chem., April 9, 2004; 279(15): 15183 - 15195. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Belli, M. M. Molina, J. Garcia-Martinez, J. E. Perez-Ortin, and E. Herrero Saccharomyces cerevisiae Glutaredoxin 5-deficient Cells Subjected to Continuous Oxidizing Conditions Are Affected in the Expression of Specific Sets of Genes J. Biol. Chem., March 26, 2004; 279(13): 12386 - 12395. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Lommel, M. Bagnat, and S. Strahl Aberrant Processing of the WSC Family and Mid2p Cell Surface Sensors Results in Cell Death of Saccharomyces cerevisiae O-Mannosylation Mutants Mol. Cell. Biol., January 1, 2004; 24(1): 46 - 57. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Reinoso-Martin, C. Schuller, M. Schuetzer-Muehlbauer, and K. Kuchler The Yeast Protein Kinase C Cell Integrity Pathway Mediates Tolerance to the Antifungal Drug Caspofungin through Activation of Slt2p Mitogen-Activated Protein Kinase Signaling Eukaryot. Cell, December 1, 2003; 2(6): 1200 - 1210. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |