HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

J. Biol. Chem., Vol. 278, Issue 24, 21510-21516, June 13, 2003

This Article Full Text Full Text (PDF) All Versions of this Article: 278/24/21510    most recent M212764200v1 Submit a Letter to Editor Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Munz, C. Articles by Pintzas, A. Search for Related Content PubMed PubMed Citation Articles by Munz, C. Articles by Pintzas, A. Social Bookmarking                      What's this?

TAF7 (TAF_II55) Plays a Role in the Transcription Activation by c-Jun^*

From the ^a Division of Signal Transduction and Growth Control, Deutsches Krebforschungszentrum, 69120 Heidelberg, Germany, ^c Laboratory of Signal Mediated Gene Expression, Institute of Biological Research and Biotechnology, National Hellenic Research Foundation, 48 Vassileos Constantinou Avenue, 116 35 Athens, Greece, ^e Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS/INSERM/ULP, 67404, Illkirch Cedex BP 10142, France

c-Jun is a member of the AP-1 family of transcription factors regulating expression of specific target genes in a variety of cellular processes including proliferation, stress response, and tumorigenicity. In the present study we have analyzed the mechanism of c-Jun function as a transactivator with respect to members of the basal transcription machinery, TATA-binding protein-associated factors (TAFs). We show that one member of the family, human TAF7 (formerly TAF_II55), physically interacts with c-Jun through two independent interaction domains, within the N- and C-terminal part of c-Jun. Interaction in vitro correlates with enhanced transactivation function of c-Jun in HEK293 and COS cells in the presence of increasing amounts of TAF7. TAF7 interacts preferentially with DNA-bound phosphorylated c-Jun, suggesting that TAF7 represents a novel c-Jun co-activator mediating activation of AP-1 target genes in response to extracellular signals.

Received for publication, December 16, 2002 , and in revised form, April 2, 2003.

^* This work was supported by the European Union through the Training and Mobility of Research network FMRX-CT96-0044 and the Biomed-2 Program, by the Greek Secretariat of Research and Technology, and by grants from the Deutsche Forschungsgemeinschaft and CNRS of France. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

^b Present address: Roche Diagnostics, 68305 Mannheim, Germany.

^d Present address: Institut Curie, 26, rue d' Ulm, 75248 Paris Cedex 05, France.

^f Present address: IPBS 205 route de Narbonne 31077 Toulouse, France.

^g Present address: Medical School, University of Athens, Mikras Asias 75, Athens, Greece.

^h Present address: Promega GmbH, 68199 Mannheim, Germany.

ⁱ To whom correspondence may be addressed: Deutsches Krebforschungszentrum, Division of Signal Transduction and Growth Control (B-0800), Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany. Tel.: 49-6221-42-4570; Fax: 49-6221-42-4554; E-mail: p.angel{at}dkfz.de. ^j To whom correspondence may be addressed: Laboratory of Signal Mediated Gene Expression, Institute of Biological Research and Biotechnology, National Hellenic Research Foundation, 48, Vas. Constantinou Ave., 116 35 Athens, Greece. Tel.: 30210-7273753; Fax: 30210-7273755; E-mail: apint{at}eie.gr.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				W.-L. Liu, R. A. Coleman, E. Ma, P. Grob, J. L. Yang, Y. Zhang, G. Dailey, E. Nogales, and R. Tjian Structures of three distinct activator-TFIID complexes Genes & Dev., July 1, 2009; 23(13): 1510 - 1521. [Abstract] [Full Text] [PDF]

				R. J.C. Slebos, Y. Yi, K. Ely, J. Carter, A. Evjen, X. Zhang, Y. Shyr, B. M. Murphy, A. J. Cmelak, B. B. Burkey, et al. Gene Expression Differences Associated with Human Papillomavirus Status in Head and Neck Squamous Cell Carcinoma Clin. Cancer Res., February 1, 2006; 12(3): 701 - 709. [Abstract] [Full Text] [PDF]

				B. Miotto, T. Sagnier, H. Berenger, D. Bohmann, J. Pradel, and Y. Graba Chameau HAT and DRpd3 HDAC function as antagonistic cofactors of JNK/AP-1-dependent transcription during Drosophila metamorphosis Genes & Dev., January 1, 2006; 20(1): 101 - 112. [Abstract] [Full Text] [PDF]

				M. Su, A. K. Bansal, R. Mantovani, and J. Sodek Recruitment of Nuclear Factor Y to the Inverted CCAAT Element (ICE) by c-Jun and E1A Stimulates Basal Transcription of the Bone Sialoprotein Gene in Osteosarcoma Cells J. Biol. Chem., November 18, 2005; 280(46): 38365 - 38375. [Abstract] [Full Text] [PDF]

				E. M. Ongeri, M. F. Verderame, and J. M. Hammond Follicle-Stimulating Hormone Induction of Ovarian Insulin-Like Growth Factor-Binding Protein-3 Transcription Requires a TATA Box-Binding Protein and the Protein Kinase A and Phosphatidylinositol-3 Kinase Pathways Mol. Endocrinol., July 1, 2005; 19(7): 1837 - 1848. [Abstract] [Full Text] [PDF]

				J. Fukuchi, R. A. Hiipakka, J. M. Kokontis, K. Nishimura, K. Igarashi, and S. Liao TATA-binding Protein-associated Factor 7 Regulates Polyamine Transport Activity and Polyamine Analog-induced Apoptosis J. Biol. Chem., July 16, 2004; 279(29): 29921 - 29929. [Abstract] [Full Text] [PDF]