|
|
|
|||||||
|
|||||||||
J. Biol. Chem., Vol. 278, Issue 24, 21631-21638, June 13, 2003
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
NF-
B Promotes Breast Cancer Cell Migration and Metastasis by Inducing the Expression of the Chemokine Receptor CXCR4*
¶ || ** 
|| ** ¶¶ ||||
From the
Departments of Surgery, ¶Microbiology and Immunology, Medicine, and ¶¶Biochemistry and Molecular Biology and
the ||Walther Oncology Center, Indiana
University School of Medicine, Indianapolis, Indiana 46202 and the**
Walther Cancer Institute, Indianapolis,
Indiana 46208
Metastasis of cancer cells is a complex process involving multiple steps including invasion, angiogenesis, and trafficking of cancer cells through blood vessels, extravasations, organ-specific homing, and growth. While matrix metalloproteinases, urokinase-type plasminogen activator, and cytokines play a major role in invasion and angiogenesis, chemokines such as stromal derived factor-1
(SDF-1) and their receptors such as CXCR4 are thought to play a critical role in motility, homing, and proliferation of cancer cells at specific metastatic sites. We and others have previously reported that the extracellular signal-activated transcription factor NF-
B up-regulates the expression of matrix metalloproteinases, urokinase-type plasminogen activator, and cytokines in highly metastatic breast cancer cell lines. In this report, we demonstrate that NF-B regulates the motility of breast cancer cells by directly up-regulating the expression of CXCR4. Overexpression of the inhibitor of B (IB) in breast cancer cells with constitutive NF-B activity resulted in reduced expression of CXCR4 and a corresponding loss of SDF-1-mediated migration in vitro. Introduction of CXCR4 cDNA into IB-expressing cells restored SDF-1-mediated migration. Electrophoretic mobility shift assays and transient transfection assays revealed that the NF-B subunits p65 and p50 bind directly to sequences within the –66 to +7 region of the CXCR4 promoter and activate transcription. We also show that the cell surface expression of CXCR4 and the SDF-1-mediated migration are enhanced in breast cancer cells isolated from mammary fat pad xenografts compared with parental cells grown in culture. A further increase in CXCR4 cell surface expression and SDF-1-mediated migration was observed with cancer cells that metastasized to the lungs. Taken together, these results implicate NF-B in the migration and the organ-specific homing of metastatic breast cancer cells.
Received for publication, January 20, 2003 , and in revised form, March 17, 2003.
* This work was supported by American Cancer Society Grant RPG-00-122-01-TBE, American Institute for Cancer Research Grant 00A047, National Institutes of Health Grant CA82208, and the Phi Beta Psi Sorority (all to H. N.) and by National Institutes of Health Grants DK53674 and HL67384 (to H. E. B.). The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
Both authors contributed equally to this work.
Supported by National Institutes of Health T32 Training Program Grant DK07519 (to H. E. B.).
|||| To whom correspondence should be addressed: R4-202 Indiana Cancer Research Inst., 1044 W. Walnut St., Indianapolis, IN 46202. Tel.: 317-278-2238; Fax: 317-274-0396; E-mail: hnakshat{at}iupui.edu.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  S. Nimmagadda, M. Pullambhatla, and M. G. Pomper Immunoimaging of CXCR4 Expression in Brain Tumor Xenografts Using SPECT/CT J. Nucl. Med., July 1, 2009; 50(7): 1124 - 1130. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. D. Altenburg and R. A. Siddiqui Omega-3 Polyunsaturated Fatty Acids Down-Modulate CXCR4 Expression and Function in MDA-MB-231 Breast Cancer Cells Mol. Cancer Res., July 1, 2009; 7(7): 1013 - 1020. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Cabioglu, A. A. Sahin, P. Morandi, F. Meric-Bernstam, R. Islam, H. Y. Lin, C. D. Bucana, A. M. Gonzalez-Angulo, G. N. Hortobagyi, and M. Cristofanilli Chemokine receptors in advanced breast cancer: differential expression in metastatic disease sites with diagnostic and therapeutic implications Ann. Onc., June 1, 2009; 20(6): 1013 - 1019. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Cohen, Z. Chen, S.-L. Lu, X. P. Yang, P. Arun, R. Ehsanian, M. S. Brown, H. Lu, B. Yan, O. Diallo, et al. Attenuated Transforming Growth Factor {beta} Signaling Promotes Nuclear Factor-{kappa}B Activation in Head and Neck Cancer Cancer Res., April 15, 2009; 69(8): 3415 - 3424. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. B. Aggarwal, R.V. Vijayalekshmi, and B. Sung Targeting Inflammatory Pathways for Prevention and Therapy of Cancer: Short-Term Friend, Long-Term Foe Clin. Cancer Res., January 15, 2009; 15(2): 425 - 430. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Lee, J. M. Kim, and E. J. Lee Functional expression of CXCR4 in somatotrophs: CXCL12 activates GH gene, GH production and secretion, and cellular proliferation J. Endocrinol., November 1, 2008; 199(2): 191 - 199. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. He, L. Fang, J. Wang, Y. Yi, S. Zhang, and X. Xie Bryostatin-5 Blocks Stromal Cell-Derived Factor-1 Induced Chemotaxis via Desensitization and Down-regulation of Cell Surface CXCR4 Receptors Cancer Res., November 1, 2008; 68(21): 8678 - 8686. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Sung, S. Jhurani, K. S. Ahn, Y. Mastuo, T. Yi, S. Guha, M. Liu, and B. B. Aggarwal Zerumbone Down-regulates Chemokine Receptor CXCR4 Expression Leading to Inhibition of CXCL12-Induced Invasion of Breast and Pancreatic Tumor Cells Cancer Res., November 1, 2008; 68(21): 8938 - 8944. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. L. Wagner, T.-A. Moo, N. Arora, Y.-F. Liu, R. Zarnegar, T. Scognamiglio, and T. J. Fahey III The Chemokine Receptors CXCR4 and CCR7 are Associated with Tumor Size and Pathologic Indicators of Tumor Aggressiveness in Papillary Thyroid Carcinoma Ann. Surg. Oncol., October 1, 2008; 15(10): 2833 - 2841. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Marlow, P. Strickland, J. S. Lee, X. Wu, M. PeBenito, M. Binnewies, E. K. Le, A. Moran, H. Macias, R. D. Cardiff, et al. SLITs Suppress Tumor Growth In vivo by Silencing Sdf1/Cxcr4 within Breast Epithelium Cancer Res., October 1, 2008; 68(19): 7819 - 7827. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. J. Villablanca, D. Zhou, B. Valentinis, A. Negro, L. Raccosta, L. Mauri, A. Prinetti, S. Sonnino, C. Bordignon, C. Traversari, et al. Selected natural and synthetic retinoids impair CCR7- and CXCR4-dependent cell migration in vitro and in vivo J. Leukoc. Biol., September 1, 2008; 84(3): 871 - 879. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. O. Rehman and C.-Y. Wang SDF-1{alpha} Promotes Invasion of Head and Neck Squamous Cell Carcinoma by Activating NF-{kappa}B J. Biol. Chem., July 18, 2008; 283(29): 19888 - 19894. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kunigal, S. S. Lakka, P. Joseph, N. Estes, and J. S. Rao Matrix metalloproteinase-9 Inhibition Down-Regulates Radiation-Induced Nuclear Factor-{kappa}B Activity Leading to Apoptosis in Breast Tumors Clin. Cancer Res., June 1, 2008; 14(11): 3617 - 3626. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Roccaro, X. Leleu, A. Sacco, X. Jia, M. Melhem, A.-S. Moreau, H. T. Ngo, J. Runnels, A. Azab, F. Azab, et al. Dual targeting of the proteasome regulates survival and homing in Waldenstrom macroglobulinemia Blood, May 1, 2008; 111(9): 4752 - 4763. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Tazaki, K. Miyazaki, E. Hiyama, T. Nakamoto, R. Sakai, N. Yamasaki, Z.-i. Honda, M. Noda, N. Miyasaka, T. Sueda, et al. Functional analysis of Src homology 3-encoding exon (exon 2) of p130Cas in primary fibroblasts derived from exon 2-specific knockout mice. Genes Cells, February 1, 2008; 13(2): 145 - 157. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Sethi, B. Sung, and B. B. Aggarwal Nuclear Factor-{kappa}B Activation: From Bench to Bedside Experimental Biology and Medicine, January 1, 2008; 233(1): 21 - 31. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. L. Tomchuck, K. J. Zwezdaryk, S. B. Coffelt, R. S. Waterman, E. S. Danka, and A. B. Scandurro Toll-Like Receptors on Human Mesenchymal Stem Cells Drive Their Migration and Immunomodulating Responses Stem Cells, January 1, 2008; 26(1): 99 - 107. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. De Falco, V. Guarino, E. Avilla, M. D. Castellone, P. Salerno, G. Salvatore, P. Faviana, F. Basolo, M. Santoro, and R. M. Melillo Biological Role and Potential Therapeutic Targeting of the Chemokine Receptor CXCR4 in Undifferentiated Thyroid Cancer Cancer Res., December 15, 2007; 67(24): 11821 - 11829. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Zhang, X. Jin, F. Wang, S. Wang, C. Deng, Z. Gao, and C. Guo Combined Prognostic Value of Both RelA and I{kappa}B-{alpha} Expression in Human Non Small Cell Lung Cancer Ann. Surg. Oncol., December 1, 2007; 14(12): 3581 - 3592. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. De La Luz Sierra, P. Gasperini, P. J. McCormick, J. Zhu, and G. Tosato Transcription factor Gfi-1 induced by G-CSF is a negative regulator of CXCR4 in myeloid cells Blood, October 1, 2007; 110(7): 2276 - 2285. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Xu, F. Wang, M. Di, Q. Huang, M. Wang, H. Hu, Y. Jin, J. Dong, and M. Lai Classification Based on the Combination of Molecular and Pathologic Predictors is Superior to Molecular Classification on Prognosis in Colorectal Carcinoma Clin. Cancer Res., September 1, 2007; 13(17): 5082 - 5088. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Matteucci, E. Ridolfi, P. Maroni, P. Bendinelli, and M. A. Desiderio c-Src/Histone Deacetylase 3 Interaction Is Crucial for Hepatocyte Growth Factor Dependent Decrease of CXCR4 Expression in Highly Invasive Breast Tumor Cells Mol. Cancer Res., August 1, 2007; 5(8): 833 - 845. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. L. Hsu, D. Yoon, H. H. Choi, F. Wang, R. T. Taylor, N. Chen, R. Zhang, and O. Hankinson A Proposed Mechanism for the Protective Effect of Dioxin against Breast Cancer Toxicol. Sci., August 1, 2007; 98(2): 436 - 444. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N Cabioglu, Y Gong, R Islam, K. Broglio, N Sneige, A Sahin, A. Gonzalez-Angulo, P Morandi, C Bucana, G. Hortobagyi, et al. Expression of growth factor and chemokine receptors: new insights in the biology of inflammatory breast cancer Ann. Onc., June 1, 2007; 18(6): 1021 - 1029. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ao, O. E. Franco, D. Park, D. Raman, K. Williams, and S. W. Hayward Cross-talk between Paracrine-Acting Cytokine and Chemokine Pathways Promotes Malignancy in Benign Human Prostatic Epithelium Cancer Res., May 1, 2007; 67(9): 4244 - 4253. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-W. Jang, Y. S. Kim, Y. R. Kim, H. J. Sung, and J. Ko Regulation of Human LZIP Expression by NF-{kappa}B and Its Involvement in Monocyte Cell Migration Induced by Lkn-1 J. Biol. Chem., April 13, 2007; 282(15): 11092 - 11100. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. E. Corcoran and P. Rameshwar Nuclear Factor-{kappa}B Accounts for the Repressor Effects of High Stromal Cell-Derived Factor-1{alpha} Levels on Tac1 Expression in Nontumorigenic Breast Cells Mol. Cancer Res., April 1, 2007; 5(4): 373 - 381. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Harvey, P. Mellor, H. Eldaly, T. W.J. Lennard, J. A. Kirby, and S. Ali Inhibition of CXCR4-Mediated Breast Cancer Metastasis: A Potential Role for Heparinoids? Clin. Cancer Res., March 1, 2007; 13(5): 1562 - 1570. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Tsoli, P. K Tsantoulis, A. Papalambros, B. Perunovic, D. England, D. A Rawlands, G. M Reynolds, D. Vlachodimitropoulos, S. L Morgan, C. A Spiliopoulou, et al. Simultaneous evaluation of maspin and CXCR4 in patients with breast cancer J. Clin. Pathol., March 1, 2007; 60(3): 261 - 266. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Kryczek, S. Wei, E. Keller, R. Liu, and W. Zou Stroma-derived factor (SDF-1/CXCL12) and human tumor pathogenesis Am J Physiol Cell Physiol, March 1, 2007; 292(3): C987 - C995. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Maroni, P. Bendinelli, E. Matteucci, and M. A. Desiderio HGF induces CXCR4 and CXCL12-mediated tumor invasion through Ets1 and NF-{kappa}B Carcinogenesis, February 1, 2007; 28(2): 267 - 279. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Moharita, M. Taborga, K. E. Corcoran, M. Bryan, P. S. Patel, and P. Rameshwar SDF-1{alpha} regulation in breast cancer cells contacting bone marrow stroma is critical for normal hematopoiesis Blood, November 15, 2006; 108(10): 3245 - 3252. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. W. Rahman, F. H. Sarkar, S. Banerjee, Z. Wang, D. J. Liao, X. Hong, and N. H. Sarkar Therapeutic intervention of experimental breast cancer bone metastasis by indole-3-carbinol in SCID-human mouse model. Mol. Cancer Ther., November 1, 2006; 5(11): 2747 - 2756. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Luo, H. Pan, M. Mines, K. Watson, J. Zhang, and G.-H. Fan CXCL12 Induces Tyrosine Phosphorylation of Cortactin, Which Plays a Role in CXC Chemokine Receptor 4-mediated Extracellular Signal-regulated Kinase Activation and Chemotaxis J. Biol. Chem., October 6, 2006; 281(40): 30081 - 30093. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Braeuer, C. Buneker, A. Mohr, and R. M. Zwacka Constitutively Activated Nuclear Factor-{kappa}B, but not Induced NF-{kappa}B, Leads to TRAIL Resistance by Up-Regulation of X-Linked Inhibitor of Apoptosis Protein in Human Cancer Cells Mol. Cancer Res., October 1, 2006; 4(10): 715 - 728. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. P. Mann, A. Verma, G. Sethi, B. Manavathi, H. Wang, J. Y. Fok, A. B. Kunnumakkara, R. Kumar, B. B. Aggarwal, and K. Mehta Overexpression of Tissue Transglutaminase Leads to Constitutive Activation of Nuclear Factor-{kappa}B in Cancer Cells: Delineation of a Novel Pathway. Cancer Res., September 1, 2006; 66(17): 8788 - 8795. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. E. Hochreiter, H. Xiao, E. M. Goldblatt, S. M. Gryaznov, K. D. Miller, S. Badve, G. W. Sledge, and B.-S. Herbert Telomerase Template Antagonist GRN163L Disrupts Telomere Maintenance, Tumor Growth, and Metastasis of Breast Cancer. Clin. Cancer Res., May 15, 2006; 12(10): 3184 - 3192. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Ding, M. Li, J. Zhang, N. Li, Z. Xia, Y. Hu, S. Wang, and G.-H. Fan The 73-kDa Heat Shock Cognate Protein Is a CXCR4 Binding Protein that Regulates the Receptor Endocytosis and the Receptor-Mediated Chemotaxis Mol. Pharmacol., April 1, 2006; 69(4): 1269 - 1279. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Srirangam, R. Mitra, M. Wang, J. C. Gorski, S. Badve, L. Baldridge, J. Hamilton, H. Kishimoto, J. Hawes, L. Li, et al. Effects of HIV Protease Inhibitor Ritonavir on Akt-Regulated Cell Proliferation in Breast Cancer Clin. Cancer Res., March 15, 2006; 12(6): 1883 - 1896. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Florio, S. Casagrande, F. Diana, A. Bajetto, C. Porcile, G. Zona, S. Thellung, S. Arena, A. Pattarozzi, A. Corsaro, et al. Chemokine Stromal Cell-Derived Factor 1{alpha} Induces Proliferation and Growth Hormone Release in GH4C1 Rat Pituitary Adenoma Cell Line through Multiple Intracellular Signals Mol. Pharmacol., February 1, 2006; 69(2): 539 - 546. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Goichberg, A. Kalinkovich, N. Borodovsky, M. Tesio, I. Petit, A. Nagler, I. Hardan, and T. Lapidot cAMP-induced PKC{zeta} activation increases functional CXCR4 expression on human CD34+ hematopoietic progenitors Blood, February 1, 2006; 107(3): 870 - 879. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Ishimura, H. Isomoto, S. F. Bronk, and G. J. Gores Trail induces cell migration and invasion in apoptosis-resistant cholangiocarcinoma cells Am J Physiol Gastrointest Liver Physiol, January 1, 2006; 290(1): G129 - G136. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Rennebeck, M. Martelli, and N. Kyprianou Anoikis and Survival Connections in the Tumor Microenvironment: Is There a Role in Prostate Cancer Metastasis? Cancer Res., December 15, 2005; 65(24): 11230 - 11235. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Kulbe, T. Hagemann, P. W. Szlosarek, F. R. Balkwill, and J. L. Wilson The Inflammatory Cytokine Tumor Necrosis Factor-{alpha} Regulates Chemokine Receptor Expression on Ovarian Cancer Cells Cancer Res., November 15, 2005; 65(22): 10355 - 10362. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Kukreja, A. B. Abdel-Mageed, D. Mondal, K. Liu, and K. C. Agrawal Up-regulation of CXCR4 Expression in PC-3 Cells by Stromal-Derived Factor-1{alpha} (CXCL12) Increases Endothelial Adhesion and Transendothelial Migration: Role of MEK/ERK Signaling Pathway-Dependent NF-{kappa}B Activation Cancer Res., November 1, 2005; 65(21): 9891 - 9898. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Zhang, B. Peng, and X. Chen Expressions of Nuclear Factor {kappa}B, Inducible Nitric Oxide Synthase, and Vascular Endothelial Growth Factor in Adenoid Cystic Carcinoma of Salivary Glands: Correlations with the Angiogenesis and Clinical Outcome Clin. Cancer Res., October 15, 2005; 11(20): 7334 - 7343. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Hagan, F. Al-Mulla, E. Mallon, K. Oien, R. Ferrier, B. Gusterson, J. J. Curto Garcia, and W. Kolch Reduction of Raf-1 Kinase Inhibitor Protein Expression Correlates with Breast Cancer Metastasis Clin. Cancer Res., October 15, 2005; 11(20): 7392 - 7397. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Kishimoto, Z. Wang, P. Bhat-Nakshatri, D. Chang, R. Clarke, and H. Nakshatri The p160 family coactivators regulate breast cancer cell proliferation and invasion through autocrine/paracrine activity of SDF-1{alpha}/CXCL12 Carcinogenesis, October 1, 2005; 26(10): 1706 - 1715. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G A Clines and T A Guise Hypercalcaemia of malignancy and basic research on mechanisms responsible for osteolytic and osteoblastic metastasis to bone Endocr. Relat. Cancer, September 1, 2005; 12(3): 549 - 583. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Cabioglu, M. S. Yazici, B. Arun, K. R. Broglio, G. N. Hortobagyi, J. E. Price, and A. Sahin CCR7 and CXCR4 as Novel Biomarkers Predicting Axillary Lymph Node Metastasis in T1 Breast Cancer Clin. Cancer Res., August 15, 2005; 11(16): 5686 - 5693. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kucia, R. Reca, K. Miekus, J. Wanzeck, W. Wojakowski, A. Janowska-Wieczorek, J. Ratajczak, and M. Z. Ratajczak Trafficking of Normal Stem Cells and Metastasis of Cancer Stem Cells Involve Similar Mechanisms: Pivotal Role of the SDF-1-CXCR4 Axis Stem Cells, August 1, 2005; 23(7): 879 - 894. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Hagemann, J. Wilson, H. Kulbe, N. F. Li, D. A. Leinster, K. Charles, F. Klemm, T. Pukrop, C. Binder, and F. R. Balkwill Macrophages Induce Invasiveness of Epithelial Cancer Cells Via NF-{kappa}B and JNK J. Immunol., July 15, 2005; 175(2): 1197 - 1205. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Hu, X. Deng, X. Bian, G. Li, Y. Tong, Y. Li, Q. Wang, R. Xin, X. He, G. Zhou, et al. The Expression of Functional Chemokine Receptor CXCR4 Is Associated with the Metastatic Potential of Human Nasopharyngeal Carcinoma Clin. Cancer Res., July 1, 2005; 11(13): 4658 - 4665. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Sweeney, S. Mehrotra, M. R. Sadaria, S. Kumar, N. H. Shortle, Y. Roman, C. Sheridan, R. A. Campbell, D. J. Murry, S. Badve, et al. The sesquiterpene lactone parthenolide in combination with docetaxel reduces metastasis and improves survival in a xenograft model of breast cancer Mol. Cancer Ther., June 1, 2005; 4(6): 1004 - 1012. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Fukuda, H. E. Broxmeyer, and L. M. Pelus Flt3 ligand and the Flt3 receptor regulate hematopoietic cell migration by modulating the SDF-1{alpha}(CXCL12)/CXCR4 axis Blood, April 15, 2005; 105(8): 3117 - 3126. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. C. Schimanski, S. Schwald, N. Simiantonaki, C. Jayasinghe, U. Gonner, V. Wilsberg, T. Junginger, M. R. Berger, P. R. Galle, and M. Moehler Effect of Chemokine Receptors CXCR4 and CCR7 on the Metastatic Behavior of Human Colorectal Cancer Clin. Cancer Res., March 1, 2005; 11(5): 1743 - 1750. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Pacifico, C. Mauro, C. Barone, E. Crescenzi, S. Mellone, M. Monaco, G. Chiappetta, G. Terrazzano, D. Liguoro, P. Vito, et al. Oncogenic and Anti-apoptotic Activity of NF-{kappa}B in Human Thyroid Carcinomas J. Biol. Chem., December 24, 2004; 279(52): 54610 - 54619. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. P. Smith, K. E. Luker, J. R. Garbow, J. L. Prior, E. Jackson, D. Piwnica-Worms, and G. D. Luker CXCR4 Regulates Growth of Both Primary and Metastatic Breast Cancer Cancer Res., December 1, 2004; 64(23): 8604 - 8612. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z.-l. Yuan, Y.-j. Guan, L. Wang, W. Wei, A. B. Kane, and Y. E. Chin Central Role of the Threonine Residue within the p+1 Loop of Receptor Tyrosine Kinase in STAT3 Constitutive Phosphorylation in Metastatic Cancer Cells Mol. Cell. Biol., November 1, 2004; 24(21): 9390 - 9400. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Owen, B. Chandler, P. G. Bray, S. A. Ward, C. A. Hart, D. J. Back, and S. H. Khoo Functional Correlation of P-Glycoprotein Expression and Genotype with Expression of the Human Immunodeficiency Virus Type 1 Coreceptor CXCR4 J. Virol., November 1, 2004; 78(21): 12022 - 12029. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Tacchini, C. De Ponti, E. Matteucci, R. Follis, and M.A. Desiderio Hepatocyte growth factor-activated NF-{kappa}B regulates HIF-1 activity and ODC expression, implicated in survival, differently in different carcinoma cell lines Carcinogenesis, November 1, 2004; 25(11): 2089 - 2100. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-T. Lin, C.-C. Chang, S.-T. Chen, H.-L. Chang, J.-L. Su, Y.-P. Chau, and M.-L. Kuo Cyr61 Expression Confers Resistance to Apoptosis in Breast Cancer MCF-7 Cells by a Mechanism of NF-{kappa}B-dependent XIAP Up-Regulation J. Biol. Chem., June 4, 2004; 279(23): 24015 - 24023. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B.-C. Lee, T.-H. Lee, S. Avraham, and H. K. Avraham Involvement of the Chemokine Receptor CXCR4 and Its Ligand Stromal Cell-Derived Factor 1{alpha} in Breast Cancer Cell Migration Through Human Brain Microvascular Endothelial Cells Mol. Cancer Res., June 1, 2004; 2(6): 327 - 338. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Kumar, H. Kishimoto, H. L. Chua, S. Badve, K. D. Miller, R. M. Bigsby, and H. Nakshatri Interleukin-1{alpha} Promotes Tumor Growth and Cachexia in MCF-7 Xenograft Model of Breast Cancer Am. J. Pathol., December 1, 2003; 163(6): 2531 - 2541. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. B. Rubin, A. L. Kung, R. S. Klein, J. A. Chan, Y. Sun, K. Schmidt, M. W. Kieran, A. D. Luster, and R. A. Segal A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors PNAS, November 11, 2003; 100(23): 13513 - 13518. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |