HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

J. Biol. Chem., Vol. 278, Issue 26, 23989-23995, June 27, 2003

This Article Full Text Full Text (PDF) All Versions of this Article: 278/26/23989    most recent M302157200v1 Submit a Letter to Editor Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Andersen, O. M. Articles by Willnow, T. E. Search for Related Content PubMed PubMed Citation Articles by Andersen, O. M. Articles by Willnow, T. E. Social Bookmarking                      What's this?

Essential Role of the Apolipoprotein E Receptor-2 in Sperm Development^*

Olav M. Andersen , Ching-Hei Yeung , Henrik Vorum ¶, Maren Wellner , Thomas K. Andreassen ¶, Bettina Erdmann , Eva-Christina Mueller , Joachim Herz ||, Albrecht Otto , Trevor G. Cooper  and Thomas E. Willnow  ** 

From the Max-Delbrueck-Center for Molecular Medicine and ^**Medical Faculty of the Free University, D-13125 Berlin, Germany, Institute of Reproductive Medicine of the University of Muenster, D-48149 Muenster, Germany, ^¶Department of Medical Biochemistry, University of Aarhus, DK-8000 Aarhus, Denmark, and ^||Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9046

The apolipoprotein (apo) E receptor-2 (apoER2) is a member of the low density lipoprotein receptor gene family and an important regulator of neuronal migration. It acts as a receptor for the signaling factor Reelin and provides positional cues to neurons that migrate to their proper position in the developing brain. Besides brain formation defects, apoER2-deficient mice also exhibit male infertility. The role of the receptor in male reproduction, however, remained unclear. Here we demonstrate that apoER2 is highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation. Reduced PHGPx expression in apoER2 knockout mice results in the inability of the sperm to regulate the cell volume and in abnormal sperm morphology and immotility. Because insufficient expression of PHGPx is a major cause of infertility in men, these findings not only highlight an important new function for apoER2 that is unrelated to neuronal migration, but they also suggest a possible role for apoER2 in human infertility.

Received for publication, March 3, 2003 , and in revised form, April 11, 2003.

^* These studies were funded by a grant from the National Genome Research Network of the Bundesministerium für Bildung und Forschung. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

To whom correspondence should be addressed: Max-Delbrueck-Center for Molecular Medicine, Robert-Roessle-Strasse 10, D-13125 Berlin, Germany. Tel.: 49-30-9406-2569; Fax: 49-30-9406-3382; E-mail: willnow{at}mdc-berlin.de.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				P Sipila, J Jalkanen, I T Huhtaniemi, and M Poutanen Novel epididymal proteins as targets for the development of post-testicular male contraception Reproduction, March 1, 2009; 137(3): 379 - 389. [Abstract] [Full Text] [PDF]

				Z. Wang, E. E Widgren, R. T Richardson, and M. G O'Rand Characterization of an Eppin Protein Complex from Human Semen and Spermatozoa Biol Reprod, September 1, 2007; 77(3): 476 - 484. [Abstract] [Full Text] [PDF]

				F. Suzuki-Toyota, C. Ito, Y. Toyama, M. Maekawa, R. Yao, T. Noda, H. Iida, and K. Toshimori Factors Maintaining Normal Sperm Tail Structure During Epididymal Maturation Studied in Gopc / Mice Biol Reprod, July 1, 2007; 77(1): 71 - 82. [Abstract] [Full Text] [PDF]

				G. E. Olson, V. P. Winfrey, S. K. NagDas, K. E. Hill, and R. F. Burk Apolipoprotein E Receptor-2 (ApoER2) Mediates Selenium Uptake from Selenoprotein P by the Mouse Testis J. Biol. Chem., April 20, 2007; 282(16): 12290 - 12297. [Abstract] [Full Text] [PDF]

				T. Fayad, R. Lefebvre, J. Nimpf, D. W. Silversides, and J. G. Lussier Low-Density Lipoprotein Receptor-Related Protein 8 (LRP8) Is Upregulated in Granulosa Cells of Bovine Dominant Follicle: Molecular Characterization and Spatio-Temporal Expression Studies Biol Reprod, March 1, 2007; 76(3): 466 - 475. [Abstract] [Full Text] [PDF]

				J. Wistuba, J. Mittag, C M. Luetjens, T. G Cooper, C.-H. Yeung, E. Nieschlag, and K. Bauer Male congenital hypothyroid Pax8-/- mice are infertile despite adequate treatment with thyroid hormone J. Endocrinol., January 1, 2007; 192(1): 99 - 109. [Abstract] [Full Text] [PDF]

				B. Peterlin, B. Zorn, M. Volk, and T. Kunej Association between the apolipoprotein B signal peptide gene insertion/deletion polymorphism and male infertility Mol. Hum. Reprod., December 1, 2006; 12(12): 777 - 779. [Abstract] [Full Text] [PDF]

				U. Beffert, A. Durudas, E. J. Weeber, P. C. Stolt, K. M. Giehl, J. D. Sweatt, R. E. Hammer, and J. Herz Functional Dissection of Reelin Signaling by Site-Directed Disruption of Disabled-1 Adaptor Binding to Apolipoprotein E Receptor 2: Distinct Roles in Development and Synaptic Plasticity J. Neurosci., February 15, 2006; 26(7): 2041 - 2052. [Abstract] [Full Text] [PDF]

				S. J Meachem, S. M Ruwanpura, J. Ziolkowski, J. M Ague, M. K Skinner, and K. L Loveland Developmentally distinct in vivo effects of FSH on proliferation and apoptosis during testis maturation J. Endocrinol., September 1, 2005; 186(3): 429 - 446. [Abstract] [Full Text] [PDF]

				J-M Frenoux, P Vernet, D H Volle, A Britan, F Saez, A Kocer, J Henry-Berger, D J Mangelsdorf, J-M A Lobaccaro, and J R Drevet Nuclear oxysterol receptors, LXRs, are involved in the maintenance of mouse caput epididymidis structure and functions J. Mol. Endocrinol., October 1, 2004; 33(2): 361 - 375. [Abstract] [Full Text] [PDF]