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J. Biol. Chem., Vol. 278, Issue 29, 26572-26579, July 18, 2003

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Convergence of Wnt Signaling and Steroidogenic Factor-1 (SF-1) on Transcription of the Rat Inhibin Gene^*

Brian M. Gummow , Jonathon N. Winnay  and Gary D. Hammer   ¶

From the Departments of Molecular and Integrative Physiology and Internal Medicine, Division of Endocrinology and Metabolism, University of Michigan, Ann Arbor, Michigan 48109

The action of a variety of peptide hormones is critical for proper growth and differentiation of the urogenital ridge, which ultimately gives rise to the kidney, adrenal cortex, and gonad. One such class of peptides is the Wnt family of secreted glycoproteins that is classically involved in development of cell polarity and cell fate determination. Notably, alterations in Wnt-4 expression in mice and humans result in profound defects in urogenital ridge development, including dysregulation of kidney, gonadal, and adrenal growth. The nuclear receptor steroidogenic factor-1 (SF-1) has been implicated as a downstream effector of peptide hormone signaling during urogenital ridge development as evidenced by both the activation of SF-1-dependent transcription in the adrenal cortex by signaling molecules such as protein kinase A and by the adrenal and gonadal agenesis in mice with null mutations in SF-1. We hypothesized that Wnt-dependent signaling cascades regulate SF-1-dependent transcription of genes required for adreno-gonadal development. Specifically, the data demonstrate that -catenin synergizes with SF-1 to activate the -inhibin promoter through formation of a transcriptional complex. The activation requires an intact SF-1 RE and is independent of TCF/Lef. These data support the recent observation that -catenin can participate in nuclear receptor-mediated transcriptional activation and extend the findings to the monomer binding class of orphan nuclear receptors.

Received for publication, December 12, 2002 , and in revised form, April 8, 2003.

^* This work was supported by National Institutes of Health Grant DK 02393 and a University of Michigan Comprehensive Cancer Center Schembechlar Adrenal Cancer Research Grant (to G. D. H.). The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

^¶ To whom correspondence should be addressed: Dept. of Internal Medicine, Division of Endocrinology and Metabolism, University of Michigan, 1150 W. Medical Center Dr., 5560 MSRBII, Ann Arbor, MI 48109. Tel.: 734-763-3056; Fax: 734-936-6684; E-mail: ghammer{at}umich.edu.

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