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Originally published In Press as doi:10.1074/jbc.C200580200 on November 22, 2002

J. Biol. Chem., Vol. 278, Issue 3, 1407-1410, January 17, 2003
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ACCELERATED PUBLICATION
The Escherichia coli Copper-responsive copA Promoter Is Activated by Gold*

Jivko V. StoyanovDagger and Nigel L. Brown§

From the School of Biosciences, The University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom

The copA gene of Escherichia coli encodes a copper transporter and its promoter is normally regulated by Cu(I) ions and CueR, a MerR-like transcriptional activator. We show that CueR can also be activated by gold salts and that Cys112 and Cys120 are involved in recognition of gold, silver, and copper salts. Gold activation is unaffected by copper chelating agents but is affected by general metal chelators. This is the first example of specific regulation of transcription by gold, and we briefly speculate that the biological effects of gold antiarthritic drugs may be through their effects on copper management in eukaryotic systems.

* This work was supported by Biotechnology and Biological Sciences Research Council Grants G14071 and JIF13209 (to N. L. B.) and by the Darwin Trust of Edinburgh Studentship (to J. V. S.).The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

Dagger Present address: Dept. of Clinical Pharmacology, University of Berne, Murtenstrasse 35, CH-3010 Bern, Switzerland.

§ To whom correspondence should be addressed. Tel.: 44-121-414-4567; Fax: 44-121-414-5907; E-mail: n.l.brown@bham.ac.uk.

Copyright © 2003 by The American Society for Biochemistry and Molecular Biology, Inc.
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