HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

J. Biol. Chem., Vol. 278, Issue 3, 1407-1410, January 17, 2003

This Article Full Text Full Text (PDF) All Versions of this Article: 278/3/1407    most recent C200580200v1 Submit a Letter to Editor Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Stoyanov, J. V. Articles by Brown, N. L. Search for Related Content PubMed PubMed Citation Articles by Stoyanov, J. V. Articles by Brown, N. L. Social Bookmarking                      What's this?

ACCELERATED PUBLICATION
The Escherichia coli Copper-responsive copA Promoter Is Activated by Gold^*

Jivko V. Stoyanov and Nigel L. Brown^§

From the School of Biosciences, The University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom

The copA gene of Escherichia coli encodes a copper transporter and its promoter is normally regulated by Cu(I) ions and CueR, a MerR-like transcriptional activator. We show that CueR can also be activated by gold salts and that Cys¹¹² and Cys¹²⁰ are involved in recognition of gold, silver, and copper salts. Gold activation is unaffected by copper chelating agents but is affected by general metal chelators. This is the first example of specific regulation of transcription by gold, and we briefly speculate that the biological effects of gold antiarthritic drugs may be through their effects on copper management in eukaryotic systems.

CiteULike

Complore

Connotea

Del.icio.us

Digg

Reddit

Technorati

This article has been cited by other articles:

				K. M. Stuhlmeier The Anti-rheumatic Gold Salt Aurothiomalate Suppresses Interleukin-1beta-induced Hyaluronan Accumulation by Blocking HAS1 Transcription and by Acting as a COX-2 Transcriptional Repressor J. Biol. Chem., January 26, 2007; 282(4): 2250 - 2258. [Abstract] [Full Text] [PDF]

				A. Gaballa, M. Cao, and J. D. Helmann Two MerR homologues that affect copper induction of the Bacillus subtilis copZA operon Microbiology, December 1, 2003; 149(12): 3413 - 3421. [Abstract] [Full Text] [PDF]

				A. Changela, K. Chen, Y. Xue, J. Holschen, C. E. Outten, T. V. O'Halloran, and A. Mondragon Molecular Basis of Metal-Ion Selectivity and Zeptomolar Sensitivity by CueR Science, September 5, 2003; 301(5638): 1383 - 1387. [Abstract] [Full Text] [PDF]