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J. Biol. Chem., Vol. 278, Issue 30, 28246-28251, July 25, 2003

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Arabidopsis Histone Acetyltransferase AtGCN5 Regulates the Floral Meristem Activity through the WUSCHEL/AGAMOUS Pathway^*

Claire Bertrand, Catherine Bergounioux, Séverine Domenichini, Marianne Delarue and Dao-Xiu Zhou 

From the Institut de Biotechnologie des Plantes, CNRS UMR 8618, Université Paris-sud XI, 91405 Orsay, France

Histone acetyltransferases, which are able to acetylate histone and non-histone proteins, play important roles in gene regulation. Many histone acetyltransferases are related to yeast Gcn5, a component of two transcription regulatory complexes SAGA and ADA. In this work, by characterizing a mutation in the Arabidopsis GCN5 gene (AtGCN5) we studied the regulatory function of this gene in controlling floral meristem activity. We show that in addition to pleiotropic effects on plant development, this mutation also leads to the production of terminal flowers. The flowers show homeotic transformations of petals into stamens and sepals into filamentous structures and produce ectopic carpels. The phenotypes correlate to an expansion of the expression domains within floral meristems of the key regulatory genes WUSCHEL (WUS) and AGAMOUS (AG). These results suggest that AtGCN5 is required to regulate the floral meristem activity through the WUS/AG pathway. This study brings new elements on the elucidation of specific developmental pathways regulated by AtGCN5 and on the control mechanism of meristem regulatory gene expression.

Received for publication, March 19, 2003 , and in revised form, May 7, 2003.

^* This work was supported by Génoplante II Grants AF1999073 and AF2001019. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

To whom correspondence should be addressed. Fax: 33-1-69-15-34-25; E-mail: zhou{at}ibp.u-psud.fr.

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