HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

J. Biol. Chem., Vol. 278, Issue 33, 31067-31077, August 15, 2003

This Article Full Text Full Text (PDF) All Versions of this Article: 278/33/31067    most recent M212889200v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Boot-Handford, R. P. Articles by Poulsom, R. Search for Related Content PubMed PubMed Citation Articles by Boot-Handford, R. P. Articles by Poulsom, R. Social Bookmarking                      What's this?

A Novel and Highly Conserved Collagen (pro1(XXVII)) with a Unique Expression Pattern and Unusual Molecular Characteristics Establishes a New Clade within the Vertebrate Fibrillar Collagen Family^*

Raymond P. Boot-Handford  , Danny S. Tuckwell  ¶, Darren A. Plumb  ||, Claire Farrington Rock  and Richard Poulsom **

From the Wellcome Trust Centre for Cell-Matrix Research, School of Biological Sciences, University of Manchester, Manchester M13 9PT, United Kingdom and the ^**Histopathology Unit, Cancer Research UK, 44 Lincoln's Inn Fields, London WC2A 3PX, United Kingdom

The type XXVII collagen gene codes for a novel vertebrate fibrillar collagen that is highly conserved in man, mouse, and fish (Fugu rubripes). The pro1(XXVII) chain has a domain structure similar to that of the type B clade chains (1(V), 3(V), 1(XI), and 2(XI)). However, compared with other vertebrate fibrillar collagens (types I, II, III, V, and XI), type XXVII collagen has unusual molecular features such as no minor helical domain, a major helical domain that is short and interrupted, and a short chain selection sequence within the NC1 domain. Pro1(XXVII) mRNA is 9 kb and expressed by chondrocytes but also by a variety of epithelial cell layers in developing tissues including stomach, lung, gonad, skin, cochlear, and tooth. By Western blotting, type XXVII antisera recognized multiple bands of 240–110 kDa in tissue extracts and collagenous bands of 150–140 kDa in the conditioned medium of the differentiating chondrogenic ATDC5 cell line. Phylogenetic analyses revealed that type XXVII, together with the closely related type XXIV collagen gene, form a new, third clade (type C) within the vertebrate fibrillar collagen family. Furthermore, the exon structure of the type XXVII collagen gene is similar to, but distinct from, those of the genes coding for the type A or B clade pro chains.

Received for publication, December 18, 2002 , and in revised form, May 22, 2003.

Note Added in Proof—While this paper was under review, the paper by Pace et al. (25) on collagen XXVII was published.

^* The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

^¶ Supported by Biotechnology and Biological Sciences Research Council. Present address: Bioinformatics Group, F2G Limited, The Manchester Incubator Building, Grafton St., Manchester M13 9XX, UK.

^|| Supported by a Medical Research Council Ph.D. studentship.

Recipient of a Wellcome Trust Research Leave Award. To whom correspondence should be addressed: Wellcome Trust Centre for Cell-Matrix Research, 2.205 Stopford, School of Biological Sciences, University of Manchester, Manchester M13 9PT, UK. Fax: 161-275-5082; E-mail: ray.boot-handford{at}man.ac.uk.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				Y. Cheli, D. Jensen, P. Marchese, D. Habart, T. Wiltshire, M. Cooke, J. A. Fernandez, J. Ware, Z. M. Ruggeri, and T. J. Kunicki The Modifier of hemostasis (Mh) locus on chromosome 4 controls in vivo hemostasis of Gp6-/- mice Blood, February 1, 2008; 111(3): 1266 - 1273. [Abstract] [Full Text] [PDF]

				D. A. Plumb, V. Dhir, A. Mironov, L. Ferrara, R. Poulsom, K. E. Kadler, D. J. Thornton, M. D. Briggs, and R. P. Boot-Handford Collagen XXVII Is Developmentally Regulated and Forms Thin Fibrillar Structures Distinct from Those of Classical Vertebrate Fibrillar Collagens J. Biol. Chem., April 27, 2007; 282(17): 12791 - 12795. [Abstract] [Full Text] [PDF]

				A. V September, M. P Schwellnus, M. Collins, and W. Gibson Tendon and ligament injuries: the genetic component * COMMENTARY Br. J. Sports Med., April 1, 2007; 41(4): 241 - 246. [Full Text] [PDF]

				X. Zhang, R. P. Boot-Handford, J. Huxley-Jones, L. N. Forse, A. P. Mould, D. L. Robertson, LiLi, M. Athiyal, and M. P. Sarras Jr. The Collagens of Hydra Provide Insight into the Evolution of Metazoan Extracellular Matrices J. Biol. Chem., March 2, 2007; 282(9): 6792 - 6802. [Abstract] [Full Text] [PDF]

				L. R. Warner, R. J. Brown, S. M. C. Yingst, and J. T. Oxford Isoform-specific Heparan Sulfate Binding within the Amino-terminal Noncollagenous Domain of Collagen {alpha}1(XI) J. Biol. Chem., December 22, 2006; 281(51): 39507 - 39516. [Abstract] [Full Text] [PDF]

				J. Khoshnoodi, J.-P. Cartailler, K. Alvares, A. Veis, and B. G. Hudson Molecular Recognition in the Assembly of Collagens: Terminal Noncollagenous Domains Are Key Recognition Modules in the Formation of Triple Helical Protomers J. Biol. Chem., December 15, 2006; 281(50): 38117 - 38121. [Abstract] [Full Text] [PDF]

				Y. Ishida, H. Kubota, A. Yamamoto, A. Kitamura, H. P. Bachinger, and K. Nagata Type I Collagen in Hsp47-null Cells Is Aggregated in Endoplasmic Reticulum and Deficient in N-Propeptide Processing and Fibrillogenesis Mol. Biol. Cell, May 1, 2006; 17(5): 2346 - 2355. [Abstract] [Full Text] [PDF]

				N. Matsuo, S. Tanaka, M. K. Gordon, M. Koch, H. Yoshioka, and F. Ramirez CREB-AP1 Protein Complexes Regulate Transcription of the Collagen XXIV Gene (Col24a1) in Osteoblasts J. Biol. Chem., March 3, 2006; 281(9): 5445 - 5452. [Abstract] [Full Text] [PDF]

				G. Zhang, M. M. Miyamoto, and M. J. Cohn Lamprey type II collagen and Sox9 reveal an ancient origin of the vertebrate collagenous skeleton PNAS, February 28, 2006; 103(9): 3180 - 3185. [Abstract] [Full Text] [PDF]

				M. Selman, A. Pardo, L. Barrera, A. Estrada, S. R. Watson, K. Wilson, N. Aziz, N. Kaminski, and A. Zlotnik Gene Expression Profiles Distinguish Idiopathic Pulmonary Fibrosis from Hypersensitivity Pneumonitis Am. J. Respir. Crit. Care Med., January 15, 2006; 173(2): 188 - 198. [Abstract] [Full Text] [PDF]

				E. G. Canty and K. E. Kadler Procollagen trafficking, processing and fibrillogenesis J. Cell Sci., April 1, 2005; 118(7): 1341 - 1353. [Abstract] [Full Text] [PDF]

				A. Aouacheria, C. Cluzel, C. Lethias, M. Gouy, R. Garrone, and J.-Y. Exposito Invertebrate Data Predict an Early Emergence of Vertebrate Fibrillar Collagen Clades and an Anti-incest Model J. Biol. Chem., November 12, 2004; 279(46): 47711 - 47719. [Abstract] [Full Text] [PDF]

				P. R.-M. Siljander, S. Hamaia, A. R. Peachey, D. A. Slatter, P. A. Smethurst, W. H. Ouwehand, C. G. Knight, and R. W. Farndale Integrin Activation State Determines Selectivity for Novel Recognition Sites in Fibrillar Collagens J. Biol. Chem., November 12, 2004; 279(46): 47763 - 47772. [Abstract] [Full Text] [PDF]

				E. G. Canty, Y. Lu, R. S. Meadows, M. K. Shaw, D. F. Holmes, and K. E. Kadler Coalignment of plasma membrane channels and protrusions (fibripositors) specifies the parallelism of tendon J. Cell Biol., May 24, 2004; 165(4): 553 - 563. [Abstract] [Full Text] [PDF]

				M. Koch, J. Schulze, U. Hansen, T. Ashwodt, D. R. Keene, W. J. Brunken, R. E. Burgeson, P. Bruckner, and L. Bruckner-Tuderman A Novel Marker of Tissue Junctions, Collagen XXII J. Biol. Chem., May 21, 2004; 279(21): 22514 - 22521. [Abstract] [Full Text] [PDF]

				C. Cluzel, C. Lethias, R. Garrone, and J.-Y. Exposito Distinct Maturations of N-propeptide Domains in Fibrillar Procollagen Molecules Involved in the Formation of Heterotypic Fibrils in Adult Sea Urchin Collagenous Tissues J. Biol. Chem., March 12, 2004; 279(11): 9811 - 9817. [Abstract] [Full Text] [PDF]

				M. Koch, F. Laub, P. Zhou, R. A. Hahn, S. Tanaka, R. E. Burgeson, D. R. Gerecke, F. Ramirez, and M. K. Gordon Collagen XXIV, a Vertebrate Fibrillar Collagen with Structural Features of Invertebrate Collagens: SELECTIVE EXPRESSION IN DEVELOPING CORNEA AND BONE J. Biol. Chem., October 31, 2003; 278(44): 43236 - 43244. [Abstract] [Full Text] [PDF]

				A. McAlinden, T. A. Smith, L. J. Sandell, D. Ficheux, D. A. D. Parry, and D. J. S. Hulmes {alpha}-Helical Coiled-coil Oligomerization Domains Are Almost Ubiquitous in the Collagen Superfamily J. Biol. Chem., October 24, 2003; 278(43): 42200 - 42207. [Abstract] [Full Text] [PDF]