|
|
|
|||||||
|
|||||||||
J. Biol. Chem., Vol. 278, Issue 38, 36596-36602, September 19, 2003
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
The Herpes Simplex Virus Type 1 (HSV-1) Regulatory Protein ICP0 Interacts with and Ubiquitinates p53*
From the Medical Research Council Virology Unit, Glasgow G11 5JR, Scotland, United Kingdom
Herpes simplex virus type 1 regulatory protein ICP0 contains a zinc-binding RING finger and has been shown to induce the proteasome-dependent degradation of a number of cellular proteins in a RING finger-dependent manner during infection. This domain of ICP0 is also required to induce the formation of unanchored polyubiquitin chains in vitro in the presence of ubiquitin-conjugating enzymes UbcH5a and UbcH6. These data indicate that ICP0 has the potential to act as a RING finger ubiquitin ubiquitin-protein isopeptide ligase (E3) and to induce the degradation of certain cellular proteins through ubiquitination and proteasome-mediated degradation. Here we demonstrate that ICP0 is a genuine RING finger ubiquitin E3 ligase that can interact with and mediate the ubiquitination of the major oncoprotein p53 both in vitro and in vivo. Ubiquitination of p53 requires ICP0 to have an intact RING finger domain and occurs independently of its ability to bind to the ubiquitin-specific protease USP7.
Received for publication, January 23, 2003 , and in revised form, June 25, 2003.
* This work was supported by the Medical Research Council (to R. D. E.) and by the Human Frontiers Science Program (a fellowship awarded to C. B. to work in the laboratory of R. D. E.). The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
To whom correspondence should be addressed: Medical Research Council Virology Unit, Church St., Glasgow G11 5JR, Scotland, UK. Tel.: 141-330-3923; Fax: 141-337-2236; E-mail: r.everett{at}vir.gla.ac.uk.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  L. Wang, M. Sommer, J. Rajamani, and A. M. Arvin Regulation of the ORF61 Promoter and ORF61 Functions in Varicella-Zoster Virus Replication and Pathogenesis J. Virol., August 1, 2009; 83(15): 7560 - 7572. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Saira, Y. Zhou, and C. Jones The Infected Cell Protein 0 Encoded by Bovine Herpesvirus 1 (bICP0) Associates with Interferon Regulatory Factor 7 and Consequently Inhibits Beta Interferon Promoter Activity J. Virol., April 15, 2009; 83(8): 3977 - 3981. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Saira, S. Chowdhury, N. Gaudreault, L. da Silva, G. Henderson, A. Doster, and C. Jones The Zinc RING Finger of Bovine Herpesvirus 1-Encoded bICP0 Protein Is Crucial for Viral Replication and Virulence J. Virol., December 15, 2008; 82(24): 12060 - 12068. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Nguyen, R. M. Kraft, M. Aubert, E. Goodwin, D. DiMaio, and J. A. Blaho p53 and hTERT Determine Sensitivity to Viral Apoptosis J. Virol., December 1, 2007; 81(23): 12985 - 12995. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kummer, N. M. Turza, P. Muhl-Zurbes, M. Lechmann, C. Boutell, R. S. Coffin, R. D. Everett, A. Steinkasserer, and A. T. Prechtel Herpes Simplex Virus Type 1 Induces CD83 Degradation in Mature Dendritic Cells with Immediate-Early Kinetics via the Cellular Proteasome J. Virol., June 15, 2007; 81(12): 6326 - 6338. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Saira, Y. Zhou, and C. Jones The Infected Cell Protein 0 Encoded by Bovine Herpesvirus 1 (bICP0) Induces Degradation of Interferon Response Factor 3 and, Consequently, Inhibits Beta Interferon Promoter Activity J. Virol., April 1, 2007; 81(7): 3077 - 3086. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Yang, L. M. Rozan, E. R. McDonald III, A. Navaraj, J. J. Liu, E. M. Matthew, W. Wang, D. T. Dicker, and W. S. El-Deiry CARPs Are Ubiquitin Ligases That Promote MDM2-independent p53 and Phospho-p53ser20 Degradation J. Biol. Chem., February 2, 2007; 282(5): 3273 - 3281. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Sanfilippo and J. A. Blaho ICP0 Gene Expression Is a Herpes Simplex Virus Type 1 Apoptotic Trigger J. Virol., July 15, 2006; 80(14): 6810 - 6821. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Utama, Y. H. Shen, B. M. Mitchell, I. T. Makagiansar, Y. Gan, R. Muthuswamy, S. Duraisamy, D. Martin, X. Wang, M.-X. Zhang, et al. Mechanisms for human cytomegalovirus-induced cytoplasmic p53 sequestration in endothelial cells J. Cell Sci., June 15, 2006; 119(12): 2457 - 2467. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. S. Miller, R. J. Danaher, and R. J. Jacob ICP0 Is Not Required for Efficient Stress-Induced Reactivation of Herpes Simplex Virus Type 1 from Cultured Quiescently Infected Neuronal Cells. J. Virol., April 1, 2006; 80(7): 3360 - 3368. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. He, B. J. Fenner, A. K. Godwin, and J. Kwang White Spot Syndrome Virus Open Reading Frame 222 Encodes a Viral E3 Ligase and Mediates Degradation of a Host Tumor Suppressor via Ubiquitination. J. Virol., April 1, 2006; 80(8): 3884 - 3892. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. W. Yap, M. P. Dodding, and J. P. Stoye Trim-cyclophilin a fusion proteins can restrict human immunodeficiency virus type 1 infection at two distinct phases in the viral life cycle. J. Virol., April 1, 2006; 80(8): 4061 - 4067. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. B. Abramovitch, R. Janjusevic, C. E. Stebbins, and G. B. Martin Type III effector AvrPtoB requires intrinsic E3 ubiquitin ligase activity to suppress plant cell death and immunity PNAS, February 21, 2006; 103(8): 2851 - 2856. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Schlieker, G. A. Korbel, L. M. Kattenhorn, and H. L. Ploegh A Deubiquitinating Activity Is Conserved in the Large Tegument Protein of the Herpesviridae J. Virol., December 15, 2005; 79(24): 15582 - 15585. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Wilson, S. D. Forney, A. M. Ricci, E. G. Allen, K. L. Hefferon, and L. K. Miller Expression and Mutational Analysis of Autographa californica Nucleopolyhedrovirus HCF-1: Functional Requirements for Cysteine Residues J. Virol., November 15, 2005; 79(22): 13900 - 13914. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Naito, K. R. Mott, N. Osorio, L. Jin, and G.-C. Perng Herpes simplex virus type 1 immediate-early protein ICP0 diffuses out of infected rabbit corneas J. Gen. Virol., November 1, 2005; 86(11): 2979 - 2988. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Boutell, M. Canning, A. Orr, and R. D. Everett Reciprocal Activities between Herpes Simplex Virus Type 1 Regulatory Protein ICP0, a Ubiquitin E3 Ligase, and Ubiquitin-Specific Protease USP7 J. Virol., October 1, 2005; 79(19): 12342 - 12354. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Shirata, A. Kudoh, T. Daikoku, Y. Tatsumi, M. Fujita, T. Kiyono, Y. Sugaya, H. Isomura, K. Ishizaki, and T. Tsurumi Activation of Ataxia Telangiectasia-mutated DNA Damage Checkpoint Signal Transduction Elicited by Herpes Simplex Virus Infection J. Biol. Chem., August 26, 2005; 280(34): 30336 - 30341. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Vichi, D. M. Payne, G. Pacheco-Rodriguez, J. Moss, and M. Vaughan E3 ubiquitin ligase activity of the trifunctional ARD1 (ADP-ribosylation factor domain protein 1) PNAS, February 8, 2005; 102(6): 1945 - 1950. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Henderson, Y. Zhang, M. Inman, D. Jones, and C. Jones Infected cell protein 0 encoded by bovine herpesvirus 1 can activate caspase 3 when overexpressed in transfected cells J. Gen. Virol., December 1, 2004; 85(12): 3511 - 3516. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-C. Geoffroy, A. L. Epstein, E. Toublanc, P. Moullier, and A. Salvetti Herpes Simplex Virus Type 1 ICP0 Protein Mediates Activation of Adeno-Associated Virus Type 2 rep Gene Expression from a Latent Integrated Form J. Virol., October 15, 2004; 78(20): 10977 - 10986. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Canning, C. Boutell, J. Parkinson, and R. D. Everett A RING Finger Ubiquitin Ligase Is Protected from Autocatalyzed Ubiquitination and Degradation by Binding to Ubiquitin-specific Protease USP7 J. Biol. Chem., September 10, 2004; 279(37): 38160 - 38168. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Rajendra, D. Malegaonkar, P. Pungaliya, H. Marshall, Z. Rasheed, J. Brownell, L. F. Liu, S. Lutzker, A. Saleem, and E. H. Rubin Topors Functions as an E3 Ubiquitin Ligase with Specific E2 Enzymes and Ubiquitinates p53 J. Biol. Chem., August 27, 2004; 279(35): 36440 - 36444. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Boutell and R. D. Everett Herpes Simplex Virus Type 1 Infection Induces the Stabilization of p53 in a USP7- and ATM-Independent Manner J. Virol., August 1, 2004; 78(15): 8068 - 8077. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Lomonte, J. Thomas, P. Texier, C. Caron, S. Khochbin, and A. L. Epstein Functional Interaction between Class II Histone Deacetylases and ICP0 of Herpes Simplex Virus Type 1 J. Virol., July 1, 2004; 78(13): 6744 - 6757. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. D. Burch and S. K. Weller Nuclear Sequestration of Cellular Chaperone and Proteasomal Machinery during Herpes Simplex Virus Type 1 Infection J. Virol., July 1, 2004; 78(13): 7175 - 7185. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Hagglund and B. Roizman Role of ICP0 in the Strategy of Conquest of the Host Cell by Herpes Simplex Virus 1 J. Virol., March 1, 2004; 78(5): 2169 - 2178. [Full Text] [PDF]
|
|
|
|
|
|
R. D. Everett, C. Boutell, and A. Orr Phenotype of a Herpes Simplex Virus Type 1 Mutant That Fails To Express Immediate-Early Regulatory Protein ICP0 J. Virol., February 15, 2004; 78(4): 1763 - 1774. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |