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J. Biol. Chem., Vol. 278, Issue 4, 2750-2757, January 24, 2003
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From the Department of Biochemistry and Molecular Biology, Shriners
Hospital for Children, Oregon Health and Science University, Portland,
Oregon 97239, the § Department of Cell Biology and Medicine,
New York University, New York, New York 10016, and the
¶ Department of Medical Molecular Biology, University of
Lübeck, Ratzeburger Allee 160, D-23538 Lübeck, Germany
Latent transforming growth factor
Latent Transforming Growth Factor
-binding Protein 1 Interacts with Fibrillin and Is a Microfibril-associated Protein*
,
-binding
protein 1 (LTBP-1) targets latent complexes of transforming growth
factor to the extracellular matrix, where the latent
cytokine is subsequently activated by several different mechanisms.
Fibrillins are extracellular matrix macromolecules whose primary
function is architectural: fibrillins assemble into ultrastructurally
distinct microfibrils that are ubiquitous in the connective tissue
space. LTBPs and fibrillins are highly homologous molecules, and
colocalization in the matrix of cultured cells has been reported. To
address whether LTBP-1 functions architecturally like fibrillins,
microfibrils were extracted from tissues and analyzed immunochemically.
In addition, binding studies were conducted to determine whether LTBP-1
interacts with fibrillins. LTBP-1 was not detected in extracted beaded-string microfibrils, suggesting that LTBP-1 is not an integral structural component of microfibrils. However, binding studies demonstrated interactions between LTBP-1 and fibrillins. The binding site was within three domains of the LTBP-1 C terminus, and in fibrillin-1 the site was defined within four domains near the N
terminus. Immunolocalization data were consistent with the hypothesis that LTBP-1 is a fibrillin-associated protein present in certain tissues but not in others. In tissues where LTBP-1 is not expressed, LTBP-4 may substitute for LTBP-1, because the C-terminal end of LTBP-4
binds equally well to fibrillin. A model depicting the relationship
between LTBP-1 and fibrillin microfibrils is proposed.
*
This work was supported by grants from the Shriners
Hospitals for Children (to L. Y. S. and D. R. K.),
the Scleroderma Foundation (to L. Y. S.), the Deutsche
Forschungsgemeinschaft (to D. P. R.), and National Institutes
of Health Grants CA 23753 and CA 34282 and DE13742 (to D. B. R.).The costs of publication of this
article were defrayed in part by the
payment of page charges. The article must therefore be hereby marked
"advertisement" in
accordance with 18 U.S.C. Section
1734 solely to indicate this fact.
Current address: Dept. of Dermatology, Nagoya City University
Medical School, Kawasumi 1, Mizuho-cho, Mizuho-ku, Nagoya, Aichi, Japan
467-8602.
To whom correspondence should be addressed: Shriners Hospital
for Children, 3101 S.W. Sam Jackson Park Rd., Portland, OR 97239. Tel.:
503-221-3436; Fax: 503-221-3451; E-mail: LYS@SHCC.org.
Copyright © 2003 by The American Society for Biochemistry and Molecular Biology, Inc.
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|
|
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|
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|
|
|
|
 |
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|
|
|
|
 |
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|
|
|
|
 |
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|
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|
|
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|
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|
|
|
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|
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M. Hyytiainen and J. Keski-Oja Latent TGF-{beta} binding protein LTBP-2 decreases fibroblast adhesion to fibronectin J. Cell Biol., December 22, 2003; 163(6): 1363 - 1374. [Abstract] [Full Text] [PDF]
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